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Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease.
Neuropathol Appl Neurobiol. 2004 Aug; 30(4):329-37.NA

Abstract

Doppel (Dpl) is a prion-like protein encoded by the gene PRND, which has been found downstream of the prion gene PRNP in several species. The present study examines by immunohistochemistry Dpl expression in brain samples from 10 patients with Alzheimer's disease (AD), three patients with Pick's disease, four patients with Parkinson's disease, eight patients with diffuse Lewy body disease (DLBD), six patients with sporadic Creutzfeldt-Jakob disease (CJD) methionine/methionine at the codon 129, two patients with sporadic CJD methionine/valine at the codon 129 and numerous kuru plaques in the cerebellum, one patient with fatal familial insomnia (FFI), and 10 age-matched controls. In the adult human brain, Dpl immunoreactivity was restricted to scattered granule cells of the cerebellum and scattered small granules in the cerebral cortex. Dpl immunoreactivity was seen around betaA4 amyloid deposits in neuritic plaques, but not in diffuse plaques, AD and the common form of DLBD. Neurofibrillary tangles, Pick bodies and Lewy bodies were not stained with anti-Dpl antibodies. No modifications in Dpl immunoreactivity were observed in CJD excepting those associated with accompanying senile plaques. No Dpl-positive deposits were seen in FFI. Whether Dpl in neuritic plaques may attenuate amyloid-induced oxidative stress and participate in the glial response around amyloid cores is discussed in light of the few available data on Dpl functions.

Authors+Show Affiliations

Institut de Neuropatologia, Servei Anatomia Patológica, Hospital de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat, Spain. 8082ifa@comb.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15305978

Citation

Ferrer, I, et al. "Selective PrP-like Protein, Doppel Immunoreactivity in Dystrophic Neurites of Senile Plaques in Alzheimer's Disease." Neuropathology and Applied Neurobiology, vol. 30, no. 4, 2004, pp. 329-37.
Ferrer I, Freixas M, Blanco R, et al. Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease. Neuropathol Appl Neurobiol. 2004;30(4):329-37.
Ferrer, I., Freixas, M., Blanco, R., Carmona, M., & Puig, B. (2004). Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease. Neuropathology and Applied Neurobiology, 30(4), 329-37.
Ferrer I, et al. Selective PrP-like Protein, Doppel Immunoreactivity in Dystrophic Neurites of Senile Plaques in Alzheimer's Disease. Neuropathol Appl Neurobiol. 2004;30(4):329-37. PubMed PMID: 15305978.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease. AU - Ferrer,I, AU - Freixas,M, AU - Blanco,R, AU - Carmona,M, AU - Puig,B, PY - 2004/8/13/pubmed PY - 2004/10/6/medline PY - 2004/8/13/entrez SP - 329 EP - 37 JF - Neuropathology and applied neurobiology JO - Neuropathol Appl Neurobiol VL - 30 IS - 4 N2 - Doppel (Dpl) is a prion-like protein encoded by the gene PRND, which has been found downstream of the prion gene PRNP in several species. The present study examines by immunohistochemistry Dpl expression in brain samples from 10 patients with Alzheimer's disease (AD), three patients with Pick's disease, four patients with Parkinson's disease, eight patients with diffuse Lewy body disease (DLBD), six patients with sporadic Creutzfeldt-Jakob disease (CJD) methionine/methionine at the codon 129, two patients with sporadic CJD methionine/valine at the codon 129 and numerous kuru plaques in the cerebellum, one patient with fatal familial insomnia (FFI), and 10 age-matched controls. In the adult human brain, Dpl immunoreactivity was restricted to scattered granule cells of the cerebellum and scattered small granules in the cerebral cortex. Dpl immunoreactivity was seen around betaA4 amyloid deposits in neuritic plaques, but not in diffuse plaques, AD and the common form of DLBD. Neurofibrillary tangles, Pick bodies and Lewy bodies were not stained with anti-Dpl antibodies. No modifications in Dpl immunoreactivity were observed in CJD excepting those associated with accompanying senile plaques. No Dpl-positive deposits were seen in FFI. Whether Dpl in neuritic plaques may attenuate amyloid-induced oxidative stress and participate in the glial response around amyloid cores is discussed in light of the few available data on Dpl functions. SN - 0305-1846 UR - https://www.unboundmedicine.com/medline/citation/15305978/Selective_PrP_like_protein_doppel_immunoreactivity_in_dystrophic_neurites_of_senile_plaques_in_Alzheimer's_disease_ L2 - https://doi.org/10.1111/j.1365-2990.2003.00534.x DB - PRIME DP - Unbound Medicine ER -