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Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder.
J Affect Disord. 2004 Aug; 81(2):167-71.JA

Abstract

BACKGROUND

This study aims to replicate the sensitivity and specificity of the Mood Disorder Questionnaire (MDQ) for bipolar disorder and assess the impact of insight on the MDQ's sensitivity. Unlike prior telephone-based validation, this is the first clinical study to assess the validity of the MDQ.

METHODS

37 consecutive patients with bipolar spectrum illness received the MDQ, as well as 36 consecutive patients with unipolar depression. MDQ diagnoses were compared to DSM-IV-based SCID diagnoses. A total of 16 bipolar patients also received the Scale to Assess Unawareness of Mental Disorder (SUMD) to measure insight.

RESULTS

Overall sensitivity for the MDQ was 0.58, higher in bipolar I disorder (0.69) than in bipolar II/NOS (0.30, P=0.06). The sample was highly insightful, but the two patients with lowest insight both had false negative screens. Patients' low ratings of severity of mania (question 3 of the MDQ) explained almost half of all false negative results. Specificity was 0.67.

CONCLUSIONS

The MDQ demonstrates good sensitivity in insightful patients with bipolar I disorder, but may be less useful in patients with impaired insight or milder bipolar spectrum conditions.

Authors+Show Affiliations

Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15306144

Citation

Miller, Christopher J., et al. "Sensitivity and Specificity of the Mood Disorder Questionnaire for Detecting Bipolar Disorder." Journal of Affective Disorders, vol. 81, no. 2, 2004, pp. 167-71.
Miller CJ, Klugman J, Berv DA, et al. Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder. J Affect Disord. 2004;81(2):167-71.
Miller, C. J., Klugman, J., Berv, D. A., Rosenquist, K. J., & Ghaemi, S. N. (2004). Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder. Journal of Affective Disorders, 81(2), 167-71.
Miller CJ, et al. Sensitivity and Specificity of the Mood Disorder Questionnaire for Detecting Bipolar Disorder. J Affect Disord. 2004;81(2):167-71. PubMed PMID: 15306144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder. AU - Miller,Christopher J, AU - Klugman,Jeffry, AU - Berv,Douglas A, AU - Rosenquist,Klara J, AU - Ghaemi,S Nassir, PY - 2002/08/23/received PY - 2003/06/03/accepted PY - 2004/8/13/pubmed PY - 2004/12/16/medline PY - 2004/8/13/entrez SP - 167 EP - 71 JF - Journal of affective disorders JO - J Affect Disord VL - 81 IS - 2 N2 - BACKGROUND: This study aims to replicate the sensitivity and specificity of the Mood Disorder Questionnaire (MDQ) for bipolar disorder and assess the impact of insight on the MDQ's sensitivity. Unlike prior telephone-based validation, this is the first clinical study to assess the validity of the MDQ. METHODS: 37 consecutive patients with bipolar spectrum illness received the MDQ, as well as 36 consecutive patients with unipolar depression. MDQ diagnoses were compared to DSM-IV-based SCID diagnoses. A total of 16 bipolar patients also received the Scale to Assess Unawareness of Mental Disorder (SUMD) to measure insight. RESULTS: Overall sensitivity for the MDQ was 0.58, higher in bipolar I disorder (0.69) than in bipolar II/NOS (0.30, P=0.06). The sample was highly insightful, but the two patients with lowest insight both had false negative screens. Patients' low ratings of severity of mania (question 3 of the MDQ) explained almost half of all false negative results. Specificity was 0.67. CONCLUSIONS: The MDQ demonstrates good sensitivity in insightful patients with bipolar I disorder, but may be less useful in patients with impaired insight or milder bipolar spectrum conditions. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/15306144/Sensitivity_and_specificity_of_the_Mood_Disorder_Questionnaire_for_detecting_bipolar_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165032703001563 DB - PRIME DP - Unbound Medicine ER -