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Thr325Ile polymorphism of the TAFI gene is related to TAFI antigen plasma levels and angiographic restenosis after percutaneous coronary interventions.
Thromb Res. 2004; 114(2):137-41.TR

Abstract

BACKGROUND

The fibrinolytic system is closely related to several processes that are involved in restenosis. We have previously shown that high pre-procedural plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) antigen predicted angiographic restenosis. The aims of this study were to evaluate the relationship between Thr325Ile polymorphisms, plasma levels of TAFI antigen, and late angiographic restenosis after percutaneous coronary intervention (PCI).

METHODS

We prospectively studied 159 patients with stable angina who underwent successful elective angioplasty or stenting of de novo native coronary artery lesions. Blood samples were drawn before the procedure. TAFI antigen levels were measured, as well as the presence of TAFI Ile325Thr genetic variation. Follow-up coronary angiography was performed in 90% of patients.

RESULTS

The genotypes based on Ile325Thr substitution had significantly different TAFI antigen levels: genotype C/C>C/T>T/T (111+/-29%, 87+/-24%, and 59+/-22%, respectively, p<0.006). T/T genotype was associated with lower rates of restenosis compared to C/T and C/C genotypes (25% versus 37% and 33%, respectively, p<0.05).

CONCLUSIONS

These data suggest that plasma TAFI antigen levels are genetically controlled. The T/T Thr325Ile polymorphism of the TAFI gene is associated with lower plasma levels of TAFI antigen and lower restenosis rates after PCI.

Authors+Show Affiliations

The Roy and Ann Foss Cardiovascular Research Program, Division of Cardiology, Terrence Donnelly Heart Center, St. Michael's Hospital, 30 Bond Street, University of Toronto, Toronto, Ontario M5B 1W8, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15306156

Citation

Segev, Amit, et al. "Thr325Ile Polymorphism of the TAFI Gene Is Related to TAFI Antigen Plasma Levels and Angiographic Restenosis After Percutaneous Coronary Interventions." Thrombosis Research, vol. 114, no. 2, 2004, pp. 137-41.
Segev A, Hegele RA, Lau HK, et al. Thr325Ile polymorphism of the TAFI gene is related to TAFI antigen plasma levels and angiographic restenosis after percutaneous coronary interventions. Thromb Res. 2004;114(2):137-41.
Segev, A., Hegele, R. A., Lau, H. K., Sparkes, J. D., Teitel, J. M., Chisholm, R. J., & Strauss, B. H. (2004). Thr325Ile polymorphism of the TAFI gene is related to TAFI antigen plasma levels and angiographic restenosis after percutaneous coronary interventions. Thrombosis Research, 114(2), 137-41.
Segev A, et al. Thr325Ile Polymorphism of the TAFI Gene Is Related to TAFI Antigen Plasma Levels and Angiographic Restenosis After Percutaneous Coronary Interventions. Thromb Res. 2004;114(2):137-41. PubMed PMID: 15306156.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thr325Ile polymorphism of the TAFI gene is related to TAFI antigen plasma levels and angiographic restenosis after percutaneous coronary interventions. AU - Segev,Amit, AU - Hegele,Robert A, AU - Lau,Herbert K, AU - Sparkes,John D, AU - Teitel,Jerome M, AU - Chisholm,Robert J, AU - Strauss,Bradley H, PY - 2003/12/22/received PY - 2004/06/01/revised PY - 2004/06/01/accepted PY - 2004/8/13/pubmed PY - 2004/12/16/medline PY - 2004/8/13/entrez SP - 137 EP - 41 JF - Thrombosis research JO - Thromb. Res. VL - 114 IS - 2 N2 - BACKGROUND: The fibrinolytic system is closely related to several processes that are involved in restenosis. We have previously shown that high pre-procedural plasma levels of thrombin-activatable fibrinolysis inhibitor (TAFI) antigen predicted angiographic restenosis. The aims of this study were to evaluate the relationship between Thr325Ile polymorphisms, plasma levels of TAFI antigen, and late angiographic restenosis after percutaneous coronary intervention (PCI). METHODS: We prospectively studied 159 patients with stable angina who underwent successful elective angioplasty or stenting of de novo native coronary artery lesions. Blood samples were drawn before the procedure. TAFI antigen levels were measured, as well as the presence of TAFI Ile325Thr genetic variation. Follow-up coronary angiography was performed in 90% of patients. RESULTS: The genotypes based on Ile325Thr substitution had significantly different TAFI antigen levels: genotype C/C>C/T>T/T (111+/-29%, 87+/-24%, and 59+/-22%, respectively, p<0.006). T/T genotype was associated with lower rates of restenosis compared to C/T and C/C genotypes (25% versus 37% and 33%, respectively, p<0.05). CONCLUSIONS: These data suggest that plasma TAFI antigen levels are genetically controlled. The T/T Thr325Ile polymorphism of the TAFI gene is associated with lower plasma levels of TAFI antigen and lower restenosis rates after PCI. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/15306156/Thr325Ile_polymorphism_of_the_TAFI_gene_is_related_to_TAFI_antigen_plasma_levels_and_angiographic_restenosis_after_percutaneous_coronary_interventions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049384804002919 DB - PRIME DP - Unbound Medicine ER -