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Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed).
Life Sci. 2004 Sep 03; 75(16):2003-14.LS

Abstract

Scoparia dulcis (Sweet Broomweed) has been documented as a traditional treatment of diabetes. The administration of an aqueous extract of Scoparia dulcis at a dose of 200 mg/kg body weight significantly decreased the blood glucose with significant increase in plasma insulin level in streptozotocin diabetic rats at the end of 15 days treatment. The insulin secretagogue action of Scoparia dulcis plant extract (SPEt) was further investigated using isolated pancreatic islets from mice. SPEt at a dose of 10 microg/ml evoked 6.0 fold stimulation of insulin secretion from isolated islets indicating its insulin secretagogue activity. In addition the effect of SPEt on streptozotocin induced cell death and nitric oxide (NO) in terms of nitrite production were also examined. SPEt protected against streptozotocin- mediated cytotoxicity (88%) and NO production in rat insulinoma cell line (RINm5F). Above results suggest the glucose lowering effect of SPEt to be associated with potentiation of insulin release from pancreatic islets. Our results revealed the possible therapeutic value of Scoparia dulcis for the better control, management and prevention of diabetes mellitus progression.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15306167

Citation

Latha, Muniappan, et al. "Insulin-secretagogue Activity and Cytoprotective Role of the Traditional Antidiabetic Plant Scoparia Dulcis (Sweet Broomweed)." Life Sciences, vol. 75, no. 16, 2004, pp. 2003-14.
Latha M, Pari L, Sitasawad S, et al. Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed). Life Sci. 2004;75(16):2003-14.
Latha, M., Pari, L., Sitasawad, S., & Bhonde, R. (2004). Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed). Life Sciences, 75(16), 2003-14.
Latha M, et al. Insulin-secretagogue Activity and Cytoprotective Role of the Traditional Antidiabetic Plant Scoparia Dulcis (Sweet Broomweed). Life Sci. 2004 Sep 3;75(16):2003-14. PubMed PMID: 15306167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin-secretagogue activity and cytoprotective role of the traditional antidiabetic plant Scoparia dulcis (Sweet Broomweed). AU - Latha,Muniappan, AU - Pari,Leelavinothan, AU - Sitasawad,Sandhya, AU - Bhonde,Ramesh, PY - 2004/01/21/received PY - 2004/05/28/accepted PY - 2004/8/13/pubmed PY - 2004/10/2/medline PY - 2004/8/13/entrez SP - 2003 EP - 14 JF - Life sciences JO - Life Sci VL - 75 IS - 16 N2 - Scoparia dulcis (Sweet Broomweed) has been documented as a traditional treatment of diabetes. The administration of an aqueous extract of Scoparia dulcis at a dose of 200 mg/kg body weight significantly decreased the blood glucose with significant increase in plasma insulin level in streptozotocin diabetic rats at the end of 15 days treatment. The insulin secretagogue action of Scoparia dulcis plant extract (SPEt) was further investigated using isolated pancreatic islets from mice. SPEt at a dose of 10 microg/ml evoked 6.0 fold stimulation of insulin secretion from isolated islets indicating its insulin secretagogue activity. In addition the effect of SPEt on streptozotocin induced cell death and nitric oxide (NO) in terms of nitrite production were also examined. SPEt protected against streptozotocin- mediated cytotoxicity (88%) and NO production in rat insulinoma cell line (RINm5F). Above results suggest the glucose lowering effect of SPEt to be associated with potentiation of insulin release from pancreatic islets. Our results revealed the possible therapeutic value of Scoparia dulcis for the better control, management and prevention of diabetes mellitus progression. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/15306167/Insulin_secretagogue_activity_and_cytoprotective_role_of_the_traditional_antidiabetic_plant_Scoparia_dulcis__Sweet_Broomweed__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024320504005193 DB - PRIME DP - Unbound Medicine ER -