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Medical treatment of diabetic foot infections.
Clin Infect Dis. 2004 Aug 01; 39 Suppl 2:S104-14.CI

Abstract

Diabetic foot infections frequently cause morbidity, hospitalization, and amputations. Gram-positive cocci, especially staphylococci and also streptococci, are the predominant pathogens. Chronic or previously treated wounds often yield several microbes on culture, including gram-negative bacilli and anaerobes. Optimal culture specimens are wound tissue taken after debridement. Infection of a wound is defined clinically by the presence of purulent discharge or inflammation; systemic signs and symptoms are often lacking. Only infected wounds require antibiotic therapy, and the agents, route, and duration are predicated on the severity of infection. Mild to moderate infections can usually be treated in the outpatient setting with oral agents; severe infections require hospitalization and parenteral therapy. Empirical therapy must cover gram-positive cocci and should be broad spectrum for severe infections. Definitive therapy depends on culture results and the clinical response. Bone infection is particularly difficult to treat and often requires surgery. Several adjuvant agents may be beneficial in some cases.

Authors+Show Affiliations

Department of Medicine, University of Washington School of Medicine, and General Internal Medicine Clinic, VA Puget Sound Health Care System, Seattle 98108-1597, USA. Benjamin.Lipsky@med.va.gov

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15306988

Citation

Lipsky, Benjamin A.. "Medical Treatment of Diabetic Foot Infections." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 39 Suppl 2, 2004, pp. S104-14.
Lipsky BA. Medical treatment of diabetic foot infections. Clin Infect Dis. 2004;39 Suppl 2:S104-14.
Lipsky, B. A. (2004). Medical treatment of diabetic foot infections. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 39 Suppl 2, S104-14.
Lipsky BA. Medical Treatment of Diabetic Foot Infections. Clin Infect Dis. 2004 Aug 1;39 Suppl 2:S104-14. PubMed PMID: 15306988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical treatment of diabetic foot infections. A1 - Lipsky,Benjamin A, PY - 2004/8/13/pubmed PY - 2004/9/24/medline PY - 2004/8/13/entrez SP - S104 EP - 14 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 39 Suppl 2 N2 - Diabetic foot infections frequently cause morbidity, hospitalization, and amputations. Gram-positive cocci, especially staphylococci and also streptococci, are the predominant pathogens. Chronic or previously treated wounds often yield several microbes on culture, including gram-negative bacilli and anaerobes. Optimal culture specimens are wound tissue taken after debridement. Infection of a wound is defined clinically by the presence of purulent discharge or inflammation; systemic signs and symptoms are often lacking. Only infected wounds require antibiotic therapy, and the agents, route, and duration are predicated on the severity of infection. Mild to moderate infections can usually be treated in the outpatient setting with oral agents; severe infections require hospitalization and parenteral therapy. Empirical therapy must cover gram-positive cocci and should be broad spectrum for severe infections. Definitive therapy depends on culture results and the clinical response. Bone infection is particularly difficult to treat and often requires surgery. Several adjuvant agents may be beneficial in some cases. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15306988/Medical_treatment_of_diabetic_foot_infections_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/383271 DB - PRIME DP - Unbound Medicine ER -
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