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Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease.
Clin Immunol. 2004 Sep; 112(3):239-46.CI

Abstract

4-1BB ligand (L) expressed on antigen presenting cells (APC) interacts with 4-1BB, expressed on activated T cells and this interaction costimulates T cells to secrete cytokines and to proliferate. We investigated whether 4-1BB/4-1BBL interactions might be involved in the pathogenesis of Crohn's disease (CD). In immunohistochemistry, we found 4-1BB expression on lamina propria (LP) cells in inflamed and to a lesser extend in non-inflamed gut tissue from CD patients. mRNA levels for 4-1BB were also elevated in intestinal CD tissue. In contrast, only few 4-1BB-expressing cells were found in inflamed tissue from ulcerative colitis (UC) patients and almost no positive cells were found in control intestinal tissue. 4-1BB expression was better sustained on in vitro activated lamina propria T cells from CD patients compared to controls. Finally, agonistic anti-4-1BB antibody enhanced interferon-gamma (IFN-gamma) production and proliferation of lamina propria T cells from CD patients. Taken together, our data suggest that 4-1BB/4-1BBL interactions contribute to the persistence of gut inflammation in CD.

Authors+Show Affiliations

Clinical Immunology, University Hospital, Katholieke Universiteit Leuven, Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15308117

Citation

Maerten, Philippe, et al. "Functional Expression of 4-1BB (CD137) in the Inflammatory Tissue in Crohn's Disease." Clinical Immunology (Orlando, Fla.), vol. 112, no. 3, 2004, pp. 239-46.
Maerten P, Geboes K, De Hertogh G, et al. Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease. Clin Immunol. 2004;112(3):239-46.
Maerten, P., Geboes, K., De Hertogh, G., Shen, C., Cadot, P., Bullens, D. M., Van Assche, G., Penninckx, F., Rutgeerts, P., & Ceuppens, J. L. (2004). Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease. Clinical Immunology (Orlando, Fla.), 112(3), 239-46.
Maerten P, et al. Functional Expression of 4-1BB (CD137) in the Inflammatory Tissue in Crohn's Disease. Clin Immunol. 2004;112(3):239-46. PubMed PMID: 15308117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional expression of 4-1BB (CD137) in the inflammatory tissue in Crohn's disease. AU - Maerten,Philippe, AU - Geboes,Karel, AU - De Hertogh,Gert, AU - Shen,Chong, AU - Cadot,Pascal, AU - Bullens,Dominique M A, AU - Van Assche,Gert, AU - Penninckx,Freddy, AU - Rutgeerts,Paul, AU - Ceuppens,Jan L, PY - 2003/12/16/received PY - 2004/04/30/accepted PY - 2004/8/17/pubmed PY - 2004/9/24/medline PY - 2004/8/17/entrez SP - 239 EP - 46 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 112 IS - 3 N2 - 4-1BB ligand (L) expressed on antigen presenting cells (APC) interacts with 4-1BB, expressed on activated T cells and this interaction costimulates T cells to secrete cytokines and to proliferate. We investigated whether 4-1BB/4-1BBL interactions might be involved in the pathogenesis of Crohn's disease (CD). In immunohistochemistry, we found 4-1BB expression on lamina propria (LP) cells in inflamed and to a lesser extend in non-inflamed gut tissue from CD patients. mRNA levels for 4-1BB were also elevated in intestinal CD tissue. In contrast, only few 4-1BB-expressing cells were found in inflamed tissue from ulcerative colitis (UC) patients and almost no positive cells were found in control intestinal tissue. 4-1BB expression was better sustained on in vitro activated lamina propria T cells from CD patients compared to controls. Finally, agonistic anti-4-1BB antibody enhanced interferon-gamma (IFN-gamma) production and proliferation of lamina propria T cells from CD patients. Taken together, our data suggest that 4-1BB/4-1BBL interactions contribute to the persistence of gut inflammation in CD. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/15308117/Functional_expression_of_4_1BB__CD137__in_the_inflammatory_tissue_in_Crohn's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521661604001421 DB - PRIME DP - Unbound Medicine ER -