Tags

Type your tag names separated by a space and hit enter

The interaction between FOXO and SIRT1: tipping the balance towards survival.
Trends Cell Biol. 2004 Aug; 14(8):408-12.TC

Abstract

When overexpressed, the NAD-dependent protein deacetylase Sir2 extends the lifespan of both budding yeast and the nematode worm Caenorhabditis elegans. In the worm, this extension of lifespan requires the FOXO transcription factor daf-16. Three recent articles focusing on mammalian homologues of Sir2 and FOXO have highlighted the mechanisms that generate this genetic interaction. Mammalian SIRT1 deacetylates FOXO3 and/or FOXO4, thus attenuating FOXO-induced apoptosis and potentiating FOXO-induced cell-cycle arrest. SIRT1 might increase longevity by shifting FOXO dependent responses away from cell death and towards cell survival.

Authors+Show Affiliations

Department of Biology, University College London, London WC1E 6BT, UK.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15308206

Citation

Giannakou, Maria E., and Linda Partridge. "The Interaction Between FOXO and SIRT1: Tipping the Balance Towards Survival." Trends in Cell Biology, vol. 14, no. 8, 2004, pp. 408-12.
Giannakou ME, Partridge L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol. 2004;14(8):408-12.
Giannakou, M. E., & Partridge, L. (2004). The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends in Cell Biology, 14(8), 408-12.
Giannakou ME, Partridge L. The Interaction Between FOXO and SIRT1: Tipping the Balance Towards Survival. Trends Cell Biol. 2004;14(8):408-12. PubMed PMID: 15308206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The interaction between FOXO and SIRT1: tipping the balance towards survival. AU - Giannakou,Maria E, AU - Partridge,Linda, PY - 2004/8/17/pubmed PY - 2005/1/26/medline PY - 2004/8/17/entrez SP - 408 EP - 12 JF - Trends in cell biology JO - Trends Cell Biol. VL - 14 IS - 8 N2 - When overexpressed, the NAD-dependent protein deacetylase Sir2 extends the lifespan of both budding yeast and the nematode worm Caenorhabditis elegans. In the worm, this extension of lifespan requires the FOXO transcription factor daf-16. Three recent articles focusing on mammalian homologues of Sir2 and FOXO have highlighted the mechanisms that generate this genetic interaction. Mammalian SIRT1 deacetylates FOXO3 and/or FOXO4, thus attenuating FOXO-induced apoptosis and potentiating FOXO-induced cell-cycle arrest. SIRT1 might increase longevity by shifting FOXO dependent responses away from cell death and towards cell survival. SN - 0962-8924 UR - https://www.unboundmedicine.com/medline/citation/15308206/The_interaction_between_FOXO_and_SIRT1:_tipping_the_balance_towards_survival_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0962-8924(04)00171-0 DB - PRIME DP - Unbound Medicine ER -