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Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years.

Abstract

BACKGROUND

Deficiency of folic acid, vitamin B(6) and/or vitamin B(12) can result in elevated total plasma homocysteine concentrations (tHcy), which are considered to be a risk factor for vascular disease. Studies have shown that supplementation of the three vitamins can lower tHcy even in subjects with tHcy in the normal range.

AIM OF THE STUDY

The aim of this study was to evaluate the effect of a 6 month supplementation with vitamin B(6), B(12) and folate on the concentrations of total plasma homocysteine and serum methylmalonic acid (MMA) of elderly women.

METHODS

The study was designed as a randomized placebo controlled double-blind trial, and 220 healthy women (aged 60-91 years) were involved. The vitamin and mineral capsule contained pyridoxine (3.4 mg), folic acid (400 microg) and cobalamin (9 microg) in addition to other micronutrients. Blood concentrations of folate, cobalamin, tHcy, MMA and the activity coefficient of erythrocyte alpha-aspartic aminotransferase (alpha-EAST) were measured at baseline and after 6 months of supplementation. Dietary intake was evaluated at the beginning and the end of the intervention by two 3-day diet records.

RESULTS

Median concentrations of serum cobalamin, serum folate and erythrocyte folate increased significantly and tHcy and alpha-EAST activity (indicative of improved status of vitamin B(6)) coefficient decreased significantly in the supplemented group. Median MMA concentration of the supplemented group was significantly lower than that of the placebo group after the intervention. The vitamin supplementation had a greater decreasing effect on the tHcy concentration of volunteers with lower vitamin and higher tHcy initial concentrations. In a linear regression model, baseline tHcy, serum folate, age and alpha-EAST activity coefficient were significantly correlated with the change in tHcy. The change in MMA in the supplement group was significantly associated to the baseline MMA values.

CONCLUSIONS

Our results show that a 6 month supplementation including physiological dosages of B vitamins improves the status of these nutrients and reduces tHcy in presumed healthy elderly women.

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  • Authors+Show Affiliations

    ,

    Nutrition Physiology & Human Nutrition Unit, Institute of Food Science Centre of Applied Chemistry University of Hanover, Wunstorfer Str. 14, 30453, Hannover, Germany. maike.wolters@lw.uni-hannover.de

    ,

    Source

    European journal of nutrition 44:3 2005 Mar pg 183-92

    MeSH

    Aged
    Aged, 80 and over
    Cardiovascular Diseases
    Dietary Supplements
    Double-Blind Method
    Female
    Folic Acid
    Geriatric Assessment
    Homocysteine
    Humans
    Methylmalonic Acid
    Middle Aged
    Minerals
    Risk Assessment
    Vitamin B 12
    Vitamin B 6
    Vitamin B Complex
    Vitamins

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15309436

    Citation

    Wolters, Maike, et al. "Effect of Multivitamin Supplementation On the Homocysteine and Methylmalonic Acid Blood Concentrations in Women Over the Age of 60 Years." European Journal of Nutrition, vol. 44, no. 3, 2005, pp. 183-92.
    Wolters M, Hermann S, Hahn A. Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years. Eur J Nutr. 2005;44(3):183-92.
    Wolters, M., Hermann, S., & Hahn, A. (2005). Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years. European Journal of Nutrition, 44(3), pp. 183-92.
    Wolters M, Hermann S, Hahn A. Effect of Multivitamin Supplementation On the Homocysteine and Methylmalonic Acid Blood Concentrations in Women Over the Age of 60 Years. Eur J Nutr. 2005;44(3):183-92. PubMed PMID: 15309436.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of multivitamin supplementation on the homocysteine and methylmalonic acid blood concentrations in women over the age of 60 years. AU - Wolters,Maike, AU - Hermann,Silke, AU - Hahn,Andreas, Y1 - 2004/05/19/ PY - 2003/10/09/received PY - 2004/03/02/accepted PY - 2004/8/17/pubmed PY - 2007/11/9/medline PY - 2004/8/17/entrez SP - 183 EP - 92 JF - European journal of nutrition JO - Eur J Nutr VL - 44 IS - 3 N2 - BACKGROUND: Deficiency of folic acid, vitamin B(6) and/or vitamin B(12) can result in elevated total plasma homocysteine concentrations (tHcy), which are considered to be a risk factor for vascular disease. Studies have shown that supplementation of the three vitamins can lower tHcy even in subjects with tHcy in the normal range. AIM OF THE STUDY: The aim of this study was to evaluate the effect of a 6 month supplementation with vitamin B(6), B(12) and folate on the concentrations of total plasma homocysteine and serum methylmalonic acid (MMA) of elderly women. METHODS: The study was designed as a randomized placebo controlled double-blind trial, and 220 healthy women (aged 60-91 years) were involved. The vitamin and mineral capsule contained pyridoxine (3.4 mg), folic acid (400 microg) and cobalamin (9 microg) in addition to other micronutrients. Blood concentrations of folate, cobalamin, tHcy, MMA and the activity coefficient of erythrocyte alpha-aspartic aminotransferase (alpha-EAST) were measured at baseline and after 6 months of supplementation. Dietary intake was evaluated at the beginning and the end of the intervention by two 3-day diet records. RESULTS: Median concentrations of serum cobalamin, serum folate and erythrocyte folate increased significantly and tHcy and alpha-EAST activity (indicative of improved status of vitamin B(6)) coefficient decreased significantly in the supplemented group. Median MMA concentration of the supplemented group was significantly lower than that of the placebo group after the intervention. The vitamin supplementation had a greater decreasing effect on the tHcy concentration of volunteers with lower vitamin and higher tHcy initial concentrations. In a linear regression model, baseline tHcy, serum folate, age and alpha-EAST activity coefficient were significantly correlated with the change in tHcy. The change in MMA in the supplement group was significantly associated to the baseline MMA values. CONCLUSIONS: Our results show that a 6 month supplementation including physiological dosages of B vitamins improves the status of these nutrients and reduces tHcy in presumed healthy elderly women. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/15309436/Effect_of_multivitamin_supplementation_on_the_homocysteine_and_methylmalonic_acid_blood_concentrations_in_women_over_the_age_of_60_years_ L2 - https://dx.doi.org/10.1007/s00394-004-0510-2 DB - PRIME DP - Unbound Medicine ER -