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Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients.

Abstract

Statins are highly effective cholesterol-lowering drugs but may have broader effects on metabolism. This investigation examined effects of simvastatin on serum levels of n-6 and n-3 polyunsaturated fatty acids (PUFAs). Subjects were 106 healthy adults with hypercholesterolemia randomly assigned to receive placebo or 40 mg simvastatin daily for 24 weeks. Serum fatty acids were analyzed by gas chromatography. Total fatty acid concentration fell 22% in subjects receiving simvastatin (P<.001), with similar declines across most fatty acids. However, concentrations of arachidonic acid (AA, 20:4n-6), eicosapentanoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) were unchanged. Relative percentages of linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (LNA, 18:3n-3), decreased while AA and DHA increased (P's < or = .007). In addition, simvastatin increased the AA:EPA ratio from 15.5 to 18.8 (P<.01), and tended to increase the AA:DHA ratio (P=.053). Thus, simvastatin lowered serum fatty acid concentrations while also altering the relative percentages of important PUFAs.

Authors+Show Affiliations

Department of Medicine, Center for Clinical Pharmacology, School of Medicine, University of Pittsburgh, 4015 O'Hara Street, Old Engineering Hall, Room 506, Pittsburgh, PA 15260, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15310527

Citation

Harris, Jennifer I., et al. "Statin Treatment Alters Serum N-3 and N-6 Fatty Acids in Hypercholesterolemic Patients." Prostaglandins, Leukotrienes, and Essential Fatty Acids, vol. 71, no. 4, 2004, pp. 263-9.
Harris JI, Hibbeln JR, Mackey RH, et al. Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. Prostaglandins Leukot Essent Fatty Acids. 2004;71(4):263-9.
Harris, J. I., Hibbeln, J. R., Mackey, R. H., & Muldoon, M. F. (2004). Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 71(4), 263-9.
Harris JI, et al. Statin Treatment Alters Serum N-3 and N-6 Fatty Acids in Hypercholesterolemic Patients. Prostaglandins Leukot Essent Fatty Acids. 2004;71(4):263-9. PubMed PMID: 15310527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. AU - Harris,Jennifer I, AU - Hibbeln,Joseph R, AU - Mackey,Rachel H, AU - Muldoon,Matthew F, PY - 2004/03/15/received PY - 2004/06/14/accepted PY - 2004/8/18/pubmed PY - 2005/1/29/medline PY - 2004/8/18/entrez SP - 263 EP - 9 JF - Prostaglandins, leukotrienes, and essential fatty acids JO - Prostaglandins Leukot Essent Fatty Acids VL - 71 IS - 4 N2 - Statins are highly effective cholesterol-lowering drugs but may have broader effects on metabolism. This investigation examined effects of simvastatin on serum levels of n-6 and n-3 polyunsaturated fatty acids (PUFAs). Subjects were 106 healthy adults with hypercholesterolemia randomly assigned to receive placebo or 40 mg simvastatin daily for 24 weeks. Serum fatty acids were analyzed by gas chromatography. Total fatty acid concentration fell 22% in subjects receiving simvastatin (P<.001), with similar declines across most fatty acids. However, concentrations of arachidonic acid (AA, 20:4n-6), eicosapentanoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3) were unchanged. Relative percentages of linoleic acid (LA, 18:2n-6) and alpha-linolenic acid (LNA, 18:3n-3), decreased while AA and DHA increased (P's < or = .007). In addition, simvastatin increased the AA:EPA ratio from 15.5 to 18.8 (P<.01), and tended to increase the AA:DHA ratio (P=.053). Thus, simvastatin lowered serum fatty acid concentrations while also altering the relative percentages of important PUFAs. SN - 0952-3278 UR - https://www.unboundmedicine.com/medline/citation/15310527/Statin_treatment_alters_serum_n_3_and_n_6_fatty_acids_in_hypercholesterolemic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(04)00112-7 DB - PRIME DP - Unbound Medicine ER -