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Brazilian Sepsis Epidemiological Study (BASES study).
Crit Care. 2004 Aug; 8(4):R251-60.CC

Abstract

INTRODUCTION

Consistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome

METHODS

This is a multicenter observational cohort study performed in five private and public, mixed ICUs from two different regions of Brazil. We prospectively followed 1383 adult patients consecutively admitted to those ICUs from May 2001 to January 2002, until their discharge, 28th day of stay, or death. For all patients we collected the following data at ICU admission: age, gender, hospital and ICU admission diagnosis, APACHE II score, and associated underlying diseases. During the following days, we looked for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock criteria, as well as recording the sequential organ failure assessment score. Infection was diagnosed according to CDC criteria for nosocomial infection, and for community-acquired infection, clinical, radiological and microbiological parameters were used.

RESULTS

For the whole cohort, median age was 65.2 years (49-76), median length of stay was 2 days (1-6), and the overall 28-day mortality rate was 21.8%. Considering 1383 patients, the incidence density rates for sepsis, severe sepsis and septic shock were 61.4, 35.6 and 30.0 per 1000 patient-days, respectively. The mortality rate of patients with SIRS, sepsis, severe sepsis and septic shock increased progressively from 24.3% to 34.7%, 47.3% and 52.2%, respectively. For patients with SIRS without infection the mortality rate was 11.3%. The main source of infection was lung/respiratory tract.

CONCLUSION

Our preliminary data suggest that sepsis is a major public health problem in Brazilian ICUs, with an incidence density about 57 per 1000 patient-days. Moreover, there was a close association between ACCP/SCCM categories and mortality rate.

Authors+Show Affiliations

Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil. eliezer@einstein.br <eliezer@einstein.br>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15312226

Citation

Silva, Eliézer, et al. "Brazilian Sepsis Epidemiological Study (BASES Study)." Critical Care (London, England), vol. 8, no. 4, 2004, pp. R251-60.
Silva E, Pedro Mde A, Sogayar AC, et al. Brazilian Sepsis Epidemiological Study (BASES study). Crit Care. 2004;8(4):R251-60.
Silva, E., Pedro, M. d. e. . A., Sogayar, A. C., Mohovic, T., Silva, C. L., Janiszewski, M., Cal, R. G., de Sousa, E. F., Abe, T. P., de Andrade, J., de Matos, J. D., Rezende, E., Assunção, M., Avezum, A., Rocha, P. C., de Matos, G. F., Bento, A. M., Corrêa, A. D., Vieira, P. C., & Knobel, E. (2004). Brazilian Sepsis Epidemiological Study (BASES study). Critical Care (London, England), 8(4), R251-60.
Silva E, et al. Brazilian Sepsis Epidemiological Study (BASES Study). Crit Care. 2004;8(4):R251-60. PubMed PMID: 15312226.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brazilian Sepsis Epidemiological Study (BASES study). AU - Silva,Eliézer, AU - Pedro,Marcelo de Almeida, AU - Sogayar,Ana Cristina Beltrami, AU - Mohovic,Tatiana, AU - Silva,Carla Lika de Oliveira, AU - Janiszewski,Mariano, AU - Cal,Ruy Guilherme Rodrigues, AU - de Sousa,Erica Fernandes, AU - Abe,Thereza Phitoe, AU - de Andrade,Joel, AU - de Matos,Jorge Dias, AU - Rezende,Ederlon, AU - Assunção,Murillo, AU - Avezum,Alvaro, AU - Rocha,Patrícia C S, AU - de Matos,Gustavo Faissol Janot, AU - Bento,André Moreira, AU - Corrêa,Alice Danielli, AU - Vieira,Paulo Cesar Bastos, AU - Knobel,Elias, AU - ,, Y1 - 2004/06/15/ PY - 2004/02/13/received PY - 2004/04/22/revised PY - 2004/05/21/accepted PY - 2004/8/18/pubmed PY - 2005/11/4/medline PY - 2004/8/18/entrez SP - R251 EP - 60 JF - Critical care (London, England) JO - Crit Care VL - 8 IS - 4 N2 - INTRODUCTION: Consistent data about the incidence and outcome of sepsis in Latin American intensive care units (ICUs), including Brazil, are lacking. This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome METHODS: This is a multicenter observational cohort study performed in five private and public, mixed ICUs from two different regions of Brazil. We prospectively followed 1383 adult patients consecutively admitted to those ICUs from May 2001 to January 2002, until their discharge, 28th day of stay, or death. For all patients we collected the following data at ICU admission: age, gender, hospital and ICU admission diagnosis, APACHE II score, and associated underlying diseases. During the following days, we looked for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis, and septic shock criteria, as well as recording the sequential organ failure assessment score. Infection was diagnosed according to CDC criteria for nosocomial infection, and for community-acquired infection, clinical, radiological and microbiological parameters were used. RESULTS: For the whole cohort, median age was 65.2 years (49-76), median length of stay was 2 days (1-6), and the overall 28-day mortality rate was 21.8%. Considering 1383 patients, the incidence density rates for sepsis, severe sepsis and septic shock were 61.4, 35.6 and 30.0 per 1000 patient-days, respectively. The mortality rate of patients with SIRS, sepsis, severe sepsis and septic shock increased progressively from 24.3% to 34.7%, 47.3% and 52.2%, respectively. For patients with SIRS without infection the mortality rate was 11.3%. The main source of infection was lung/respiratory tract. CONCLUSION: Our preliminary data suggest that sepsis is a major public health problem in Brazilian ICUs, with an incidence density about 57 per 1000 patient-days. Moreover, there was a close association between ACCP/SCCM categories and mortality rate. SN - 1466-609X UR - https://www.unboundmedicine.com/medline/citation/15312226/Brazilian_Sepsis_Epidemiological_Study__BASES_study__ L2 - https://ccforum.biomedcentral.com/articles/10.1186/cc2892 DB - PRIME DP - Unbound Medicine ER -