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Depression in Parkinson's disease: conceptual issues and clinical challenges.
J Geriatr Psychiatry Neurol. 2004 Sep; 17(3):120-6.JG

Abstract

BACKGROUND

Depression frequently accompanies Parkinson's disease (PD) and may have a negative impact on activities of daily living, cognitive performance, and quality of life. Because of the symptom overlap between the 2 disorders, it may be difficult to recognize depression in PD. Moreover, the partially shared pathophysiology may make it difficult to treat depressive symptoms without influencing motor or cognitive function.

OBJECTIVE

To review the current knowledge of the epidemiology, etiology, pathophysiology, and treatment of depression in patients with Parkinson's disease.

METHOD

Discussion of recent studies and relevant literature.

CONCLUSION

Not only conceptually but also in terms of etiology, pathophysiology, and treatment, the relationship between PD and depression remains a challenge. There are still many questions to be answered. In the therapeutic domain, large, placebo-controlled trials are necessary to evaluate the efficacy of antidepressant treatment and allow the development of evidence-based guidelines.

Authors+Show Affiliations

Department of Psychiatry, Maastricht University Hospital, PO Box 5800, 6202 AZ, the Netherlands. a.leentjens@np.unimaas.nl

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15312275

Citation

Leentjens, Albert F G.. "Depression in Parkinson's Disease: Conceptual Issues and Clinical Challenges." Journal of Geriatric Psychiatry and Neurology, vol. 17, no. 3, 2004, pp. 120-6.
Leentjens AF. Depression in Parkinson's disease: conceptual issues and clinical challenges. J Geriatr Psychiatry Neurol. 2004;17(3):120-6.
Leentjens, A. F. (2004). Depression in Parkinson's disease: conceptual issues and clinical challenges. Journal of Geriatric Psychiatry and Neurology, 17(3), 120-6.
Leentjens AF. Depression in Parkinson's Disease: Conceptual Issues and Clinical Challenges. J Geriatr Psychiatry Neurol. 2004;17(3):120-6. PubMed PMID: 15312275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression in Parkinson's disease: conceptual issues and clinical challenges. A1 - Leentjens,Albert F G, PY - 2004/8/18/pubmed PY - 2004/12/24/medline PY - 2004/8/18/entrez SP - 120 EP - 6 JF - Journal of geriatric psychiatry and neurology JO - J Geriatr Psychiatry Neurol VL - 17 IS - 3 N2 - BACKGROUND: Depression frequently accompanies Parkinson's disease (PD) and may have a negative impact on activities of daily living, cognitive performance, and quality of life. Because of the symptom overlap between the 2 disorders, it may be difficult to recognize depression in PD. Moreover, the partially shared pathophysiology may make it difficult to treat depressive symptoms without influencing motor or cognitive function. OBJECTIVE: To review the current knowledge of the epidemiology, etiology, pathophysiology, and treatment of depression in patients with Parkinson's disease. METHOD: Discussion of recent studies and relevant literature. CONCLUSION: Not only conceptually but also in terms of etiology, pathophysiology, and treatment, the relationship between PD and depression remains a challenge. There are still many questions to be answered. In the therapeutic domain, large, placebo-controlled trials are necessary to evaluate the efficacy of antidepressant treatment and allow the development of evidence-based guidelines. SN - 0891-9887 UR - https://www.unboundmedicine.com/medline/citation/15312275/Depression_in_Parkinson's_disease:_conceptual_issues_and_clinical_challenges_ L2 - https://journals.sagepub.com/doi/10.1177/0891988704267456?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -