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[Clinical significance of serum transferrin receptor in differential diagnosis of anemia].
Zhonghua Nei Ke Za Zhi. 2004 Jun; 43(6):423-5.ZN

Abstract

OBJECTIVE

To study the clinical significance of the serum transferrin receptor (sTfR) and ferritin in distinguishing between iron deficiency anemia (IDA), anemia of chronic disease (ACD) and ACD with complicating IDA (ACD-IDA).

METHODS

One hundred and thirteen subjects enrolled into the study were divided into four groups including 28 health volunteers as control, 29 patients with IDA, 27 patients with ACD (sTfR level <or= 20.0 nmol/L, ACD1 group) and 29 patients with ACD-IDA (sTfR level > 20.0 nmol/L, ACD2 group). sTfR, serum ferritin (SF), serum iron (SI), total iron-binding capacity (TIBC), transferring saturation (TS) and complete blood count were measured in all the enrolled subjects or patients. Bone marrow iron stain was examined in 10 cases of ACD1 and 16 cases of ADC2.

RESULTS

In IDA group, MCV (68.0 +/- 11.3) fl was the smallest; SI, TS and SF were significantly decreased but sTfR level was increased as compared with the control group (SI) (19.6 +/- 10.1) mg/L vs (81.7 +/- 30.6) mg/L, TS (5.5 +/- 2.3)% vs (27.0 +/- 12.0)%, SF (4.3 +/- 2.8) micro g/L vs (43.3 +/- 26.8) micro g/L and sTfR (67.2 +/- 40.3) nmol/L vs (15.6 +/- 4.1) nmol/L (P <or= 0.01). SI (60.7 +/- 28.7) mg/L, and TS (21.1 +/- 9.8)% were not different statistically (P > 0.05) but SF (627.3 +/- 40.3) micro g/L level was increased in ACD1 group as compared with the control group (P < 0.01). Bone marrow iron stain showed no iron deficiency in 10 cases of ACD1. In ACD2 group, SF (320.5 +/- 156.0) micro g/L level was higher than that of the control group, but lower than that of the ACD1 group (P <or= 0.01); bone marrow iron stain showed iron depletion in 14 of the 16 patients.

CONCLUSION

High sTfR level may reflect iron deficiency status of the body and is a more sensitive parameter to diagnose iron deficiency anemia. sTfR level is less influenced by chronic inflammation, and able to distinguish ACD from ACD-IDA.

Authors+Show Affiliations

Department of Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China. chenj1001001@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15312435

Citation

Chen, Jia-lin, et al. "[Clinical Significance of Serum Transferrin Receptor in Differential Diagnosis of Anemia]." Zhonghua Nei Ke Za Zhi, vol. 43, no. 6, 2004, pp. 423-5.
Chen JL, Li SL, Xu M, et al. [Clinical significance of serum transferrin receptor in differential diagnosis of anemia]. Zhonghua Nei Ke Za Zhi. 2004;43(6):423-5.
Chen, J. L., Li, S. L., Xu, M., Wang, H. B., Ge, C. W., & Li, R. S. (2004). [Clinical significance of serum transferrin receptor in differential diagnosis of anemia]. Zhonghua Nei Ke Za Zhi, 43(6), 423-5.
Chen JL, et al. [Clinical Significance of Serum Transferrin Receptor in Differential Diagnosis of Anemia]. Zhonghua Nei Ke Za Zhi. 2004;43(6):423-5. PubMed PMID: 15312435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical significance of serum transferrin receptor in differential diagnosis of anemia]. AU - Chen,Jia-lin, AU - Li,Shu-lan, AU - Xu,Min, AU - Wang,Hai-bin, AU - Ge,Chang-wen, AU - Li,Rong-sheng, PY - 2004/8/18/pubmed PY - 2005/2/3/medline PY - 2004/8/18/entrez SP - 423 EP - 5 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 43 IS - 6 N2 - OBJECTIVE: To study the clinical significance of the serum transferrin receptor (sTfR) and ferritin in distinguishing between iron deficiency anemia (IDA), anemia of chronic disease (ACD) and ACD with complicating IDA (ACD-IDA). METHODS: One hundred and thirteen subjects enrolled into the study were divided into four groups including 28 health volunteers as control, 29 patients with IDA, 27 patients with ACD (sTfR level <or= 20.0 nmol/L, ACD1 group) and 29 patients with ACD-IDA (sTfR level > 20.0 nmol/L, ACD2 group). sTfR, serum ferritin (SF), serum iron (SI), total iron-binding capacity (TIBC), transferring saturation (TS) and complete blood count were measured in all the enrolled subjects or patients. Bone marrow iron stain was examined in 10 cases of ACD1 and 16 cases of ADC2. RESULTS: In IDA group, MCV (68.0 +/- 11.3) fl was the smallest; SI, TS and SF were significantly decreased but sTfR level was increased as compared with the control group (SI) (19.6 +/- 10.1) mg/L vs (81.7 +/- 30.6) mg/L, TS (5.5 +/- 2.3)% vs (27.0 +/- 12.0)%, SF (4.3 +/- 2.8) micro g/L vs (43.3 +/- 26.8) micro g/L and sTfR (67.2 +/- 40.3) nmol/L vs (15.6 +/- 4.1) nmol/L (P <or= 0.01). SI (60.7 +/- 28.7) mg/L, and TS (21.1 +/- 9.8)% were not different statistically (P > 0.05) but SF (627.3 +/- 40.3) micro g/L level was increased in ACD1 group as compared with the control group (P < 0.01). Bone marrow iron stain showed no iron deficiency in 10 cases of ACD1. In ACD2 group, SF (320.5 +/- 156.0) micro g/L level was higher than that of the control group, but lower than that of the ACD1 group (P <or= 0.01); bone marrow iron stain showed iron depletion in 14 of the 16 patients. CONCLUSION: High sTfR level may reflect iron deficiency status of the body and is a more sensitive parameter to diagnose iron deficiency anemia. sTfR level is less influenced by chronic inflammation, and able to distinguish ACD from ACD-IDA. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/15312435/[Clinical_significance_of_serum_transferrin_receptor_in_differential_diagnosis_of_anemia]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0578-1426&amp;year=2004&amp;vol=43&amp;issue=6&amp;fpage=423 DB - PRIME DP - Unbound Medicine ER -