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[A study on the factors influencing insulin resistance in children and adolescents].
Zhonghua Yu Fang Yi Xue Za Zhi. 2004 Jul; 38(4):234-6.ZY

Abstract

OBJECTIVE

To explore the factors influencing insulin resistance in children with different nutritional status during pubertal development.

METHODS

Three hundred children with simple obese aged 7 to 17 years, and 300 normal healthy children and 300 children with malnutrition, matched for age (+/- 3 months) and height (+/- 2 cm), were selected. Fasting serum levels of leptin, insulin, glucose, total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were measured for them.

RESULTS

Levels of fasting serum insulin in obese children, except for boys at Tanner stage I and girls at Tanner stage II, were higher than those in normal and malnutrition children (P < 0.01). Average serum level of leptin in obese boys and girls at varied Tanner stages was higher than that in normal children, and higher in normal children than that in children with malnutrition (P<0.01). Serum level of TG in obese children [(1.53 +/- 0.13) mmol/L] was higher than that in normal ones [(1.12 +/- 0.10) mmol/L] and in children with malnutrition [(1.03 +/- 0.09) mmol/L]. There was no significant difference in levels of fasting blood glucose and other blood lipids between the three groups of children. Insulin sensitivity decreased with pubertal development and its index reversely correlated with Tanner stage and serum level of leptin (r=-0.27 and -0.36, respectively, P<0.01).

CONCLUSION

Obesity (BMI), serum level of leptin and pubertal development were independent risk factors for insulin resistance in children aged 7 to 17 years.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150001, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15312580

Citation

Li, Ying, et al. "[A Study On the Factors Influencing Insulin Resistance in Children and Adolescents]." Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], vol. 38, no. 4, 2004, pp. 234-6.
Li Y, Sun CH, Wen Y, et al. [A study on the factors influencing insulin resistance in children and adolescents]. Zhonghua Yu Fang Yi Xue Za Zhi. 2004;38(4):234-6.
Li, Y., Sun, C. H., Wen, Y., & Cui, W. X. (2004). [A study on the factors influencing insulin resistance in children and adolescents]. Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine], 38(4), 234-6.
Li Y, et al. [A Study On the Factors Influencing Insulin Resistance in Children and Adolescents]. Zhonghua Yu Fang Yi Xue Za Zhi. 2004;38(4):234-6. PubMed PMID: 15312580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A study on the factors influencing insulin resistance in children and adolescents]. AU - Li,Ying, AU - Sun,Chang-Hao, AU - Wen,Ying, AU - Cui,Wen-Xiu, PY - 2004/8/18/pubmed PY - 2005/1/8/medline PY - 2004/8/18/entrez SP - 234 EP - 6 JF - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] JO - Zhonghua Yu Fang Yi Xue Za Zhi VL - 38 IS - 4 N2 - OBJECTIVE: To explore the factors influencing insulin resistance in children with different nutritional status during pubertal development. METHODS: Three hundred children with simple obese aged 7 to 17 years, and 300 normal healthy children and 300 children with malnutrition, matched for age (+/- 3 months) and height (+/- 2 cm), were selected. Fasting serum levels of leptin, insulin, glucose, total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were measured for them. RESULTS: Levels of fasting serum insulin in obese children, except for boys at Tanner stage I and girls at Tanner stage II, were higher than those in normal and malnutrition children (P < 0.01). Average serum level of leptin in obese boys and girls at varied Tanner stages was higher than that in normal children, and higher in normal children than that in children with malnutrition (P<0.01). Serum level of TG in obese children [(1.53 +/- 0.13) mmol/L] was higher than that in normal ones [(1.12 +/- 0.10) mmol/L] and in children with malnutrition [(1.03 +/- 0.09) mmol/L]. There was no significant difference in levels of fasting blood glucose and other blood lipids between the three groups of children. Insulin sensitivity decreased with pubertal development and its index reversely correlated with Tanner stage and serum level of leptin (r=-0.27 and -0.36, respectively, P<0.01). CONCLUSION: Obesity (BMI), serum level of leptin and pubertal development were independent risk factors for insulin resistance in children aged 7 to 17 years. SN - 0253-9624 UR - https://www.unboundmedicine.com/medline/citation/15312580/[A_study_on_the_factors_influencing_insulin_resistance_in_children_and_adolescents]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-9624&amp;year=2004&amp;vol=38&amp;issue=4&amp;fpage=234 DB - PRIME DP - Unbound Medicine ER -