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MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels.
Neurobiol Aging 2004; 25(9):1169-73NA

Abstract

MCP-1 levels are increased in CSF of patients with Alzheimer's disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the contrary, a significant increase of MCP-1 serum levels in AD patients carrying at least one G mutated allele was observed. Moreover, the highest peaks of MCP-1 serum levels were present in patients carrying two G alleles. Stratifying by ApoE genotype, gender or age at onset, no differences in both allele frequency and MCP-1 serum concentration were observed. The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD.

Authors+Show Affiliations

Department of Neurological Sciences, "Dino Ferrari" Center, University of Milan, IRCCS Ospedale Maggiore Policlinico, Via F. Sforza 35, 20122 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15312962

Citation

Fenoglio, Chiara, et al. "MCP-1 in Alzheimer's Disease Patients: A-2518G Polymorphism and Serum Levels." Neurobiology of Aging, vol. 25, no. 9, 2004, pp. 1169-73.
Fenoglio C, Galimberti D, Lovati C, et al. MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels. Neurobiol Aging. 2004;25(9):1169-73.
Fenoglio, C., Galimberti, D., Lovati, C., Guidi, I., Gatti, A., Fogliarino, S., ... Scarpini, E. (2004). MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels. Neurobiology of Aging, 25(9), pp. 1169-73.
Fenoglio C, et al. MCP-1 in Alzheimer's Disease Patients: A-2518G Polymorphism and Serum Levels. Neurobiol Aging. 2004;25(9):1169-73. PubMed PMID: 15312962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MCP-1 in Alzheimer's disease patients: A-2518G polymorphism and serum levels. AU - Fenoglio,Chiara, AU - Galimberti,Daniela, AU - Lovati,Carlo, AU - Guidi,Ilaria, AU - Gatti,Alberto, AU - Fogliarino,Sergio, AU - Tiriticco,Marco, AU - Mariani,Claudio, AU - Forloni,Gianluigi, AU - Pettenati,Carla, AU - Baron,Pierluigi, AU - Conti,Giancarlo, AU - Bresolin,Nereo, AU - Scarpini,Elio, PY - 2003/08/12/received PY - 2003/11/06/revised PY - 2003/11/13/accepted PY - 2004/8/18/pubmed PY - 2004/12/22/medline PY - 2004/8/18/entrez SP - 1169 EP - 73 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 25 IS - 9 N2 - MCP-1 levels are increased in CSF of patients with Alzheimer's disease (AD) compared with controls, suggesting a role in the development of dementia. Recently, a biallelic A/G polymorphism in the MCP-1 promoter at position -2518 has been found, influencing the level of MCP-1 expression in response to an inflammatory stimulus. The distribution of the A-2518G SNP was determined in 269 AD patients and in 203 healthy age matched controls, showing no differences between the two groups. On the contrary, a significant increase of MCP-1 serum levels in AD patients carrying at least one G mutated allele was observed. Moreover, the highest peaks of MCP-1 serum levels were present in patients carrying two G alleles. Stratifying by ApoE genotype, gender or age at onset, no differences in both allele frequency and MCP-1 serum concentration were observed. The A-2518G polymorphism in MCP-1 gene does not seem to be a risk factor for the development of AD, but its presence correlates with higher levels of serum MCP-1, which can contribute to increase the inflammatory process occurring in AD. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/15312962/MCP_1_in_Alzheimer's_disease_patients:_A_2518G_polymorphism_and_serum_levels_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197458004000314 DB - PRIME DP - Unbound Medicine ER -