Tags

Type your tag names separated by a space and hit enter

MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD.
Neurobiol Aging. 2004 Oct; 25(9):1197-203.NA

Abstract

With high-resolution quantitative magnetic resonance imaging (MRI) techniques, it is possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD). In the present study, 27 patients diagnosed with mild cognitive impairment (MCI) received a high-resolution MRI scan at baseline and were followed with yearly clinical evaluations. Ten of the 27 patients converted to AD during a 36-month period following the baseline clinical evaluation. Hippocampal and entorhinal cortex volumes derived from the baseline scan were compared to determine which of these two regions, known to be pathologically involved very early in the course of AD, could best differentiate MCI converters from non-converters. Although both entorhinal and hippocampal volumes were found to be independent predictors of the likelihood of conversion to AD, it was the right hemisphere entorhinal volume that best predicted conversion with a concordance rate of 93.5%.

Authors+Show Affiliations

Department of Neurological Sciences, Rush University, Chicago, IL 60612, USA. ldetoled@rush.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15312965

Citation

deToledo-Morrell, Leyla, et al. "MRI-derived Entorhinal Volume Is a Good Predictor of Conversion From MCI to AD." Neurobiology of Aging, vol. 25, no. 9, 2004, pp. 1197-203.
deToledo-Morrell L, Stoub TR, Bulgakova M, et al. MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiol Aging. 2004;25(9):1197-203.
deToledo-Morrell, L., Stoub, T. R., Bulgakova, M., Wilson, R. S., Bennett, D. A., Leurgans, S., Wuu, J., & Turner, D. A. (2004). MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. Neurobiology of Aging, 25(9), 1197-203.
deToledo-Morrell L, et al. MRI-derived Entorhinal Volume Is a Good Predictor of Conversion From MCI to AD. Neurobiol Aging. 2004;25(9):1197-203. PubMed PMID: 15312965.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD. AU - deToledo-Morrell,Leyla, AU - Stoub,T R, AU - Bulgakova,M, AU - Wilson,R S, AU - Bennett,D A, AU - Leurgans,S, AU - Wuu,J, AU - Turner,D A, PY - 2003/07/07/received PY - 2003/10/17/revised PY - 2003/12/09/accepted PY - 2004/8/18/pubmed PY - 2004/12/22/medline PY - 2004/8/18/entrez SP - 1197 EP - 203 JF - Neurobiology of aging JO - Neurobiol Aging VL - 25 IS - 9 N2 - With high-resolution quantitative magnetic resonance imaging (MRI) techniques, it is possible to examine alterations in brain anatomy in vivo and to identify regions affected in the earliest stages of Alzheimer's disease (AD). In the present study, 27 patients diagnosed with mild cognitive impairment (MCI) received a high-resolution MRI scan at baseline and were followed with yearly clinical evaluations. Ten of the 27 patients converted to AD during a 36-month period following the baseline clinical evaluation. Hippocampal and entorhinal cortex volumes derived from the baseline scan were compared to determine which of these two regions, known to be pathologically involved very early in the course of AD, could best differentiate MCI converters from non-converters. Although both entorhinal and hippocampal volumes were found to be independent predictors of the likelihood of conversion to AD, it was the right hemisphere entorhinal volume that best predicted conversion with a concordance rate of 93.5%. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/15312965/MRI_derived_entorhinal_volume_is_a_good_predictor_of_conversion_from_MCI_to_AD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197458004000375 DB - PRIME DP - Unbound Medicine ER -