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Prepulse inhibition of acoustic startle in spontaneously hypertensive rats.
Behav Brain Res. 2004 Oct 05; 154(2):331-7.BB

Abstract

Prepulse inhibition is modulated by dopaminergic drugs and is disrupted in attention-deficit hyperactivity disorder, as well as mental illnesses such as schizophrenia. Spontaneously hypertensive rats (SHR) have been proposed as an animal model of attention-deficit hyperactivity disorder and show marked alterations of dopaminergic regulation of behaviour. SHR showed significantly lower startle amplitude than Wistar-Kyoto (WKY) rats and Sprague-Dawley (SD) rats, but no difference in startle habituation. Baseline percentage prepulse inhibition was higher in SHR and WKY rats than in SD rats. Treatment with amphetamine caused significant disruption of prepulse inhibition in SHR and WKY rats, but not SD rats. In contrast, treatment with apomorphine caused prepulse-dependent disruption of prepulse inhibition in SD rats only. Both MK-801 and 8-OH-DPAT treatment caused disruption of prepulse inhibition in all three rat strains. This study shows differential changes in startle level and prepulse inhibition in SHR, however these rats are not uniformly different from either WKY rats or SD rats and WKY rats differ in a number of respects from SD rats. In conclusion, these data further reveal altered dopaminergic regulation of behaviour in SHR, but also shows that caution is needed about the control strain used to compare these animals with.

Authors+Show Affiliations

van den Buuse M
Behavioural Neuroscience Laboratory, Mental Health Research Institute of Victoria, 155 Oak Street, Parkville, Vic. 3052, Australia. mvandenbuuse@mhri.edu.au

MeSH

8-Hydroxy-2-(di-n-propylamino)tetralinAcoustic StimulationAdrenergic AgentsAmphetamineAnalysis of VarianceAnimalsApomorphineDisease Models, AnimalDizocilpine MaleateDopamine AgonistsDose-Response Relationship, RadiationExcitatory Amino Acid AntagonistsHypertensionMaleNeural InhibitionRatsRats, Inbred SHRRats, Inbred WKYRats, Sprague-DawleyReflex, AcousticReflex, StartleSerotonin Receptor AgonistsSpecies Specificity

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15313020

Citation

van den Buuse, Maarten. "Prepulse Inhibition of Acoustic Startle in Spontaneously Hypertensive Rats." Behavioural Brain Research, vol. 154, no. 2, 2004, pp. 331-7.
van den Buuse M. Prepulse inhibition of acoustic startle in spontaneously hypertensive rats. Behav Brain Res. 2004;154(2):331-7.
van den Buuse, M. (2004). Prepulse inhibition of acoustic startle in spontaneously hypertensive rats. Behavioural Brain Research, 154(2), 331-7.
van den Buuse M. Prepulse Inhibition of Acoustic Startle in Spontaneously Hypertensive Rats. Behav Brain Res. 2004 Oct 5;154(2):331-7. PubMed PMID: 15313020.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prepulse inhibition of acoustic startle in spontaneously hypertensive rats. A1 - van den Buuse,Maarten, PY - 2003/12/23/received PY - 2004/02/27/revised PY - 2004/02/27/accepted PY - 2004/8/18/pubmed PY - 2004/11/2/medline PY - 2004/8/18/entrez SP - 331 EP - 7 JF - Behavioural brain research JO - Behav Brain Res VL - 154 IS - 2 N2 - Prepulse inhibition is modulated by dopaminergic drugs and is disrupted in attention-deficit hyperactivity disorder, as well as mental illnesses such as schizophrenia. Spontaneously hypertensive rats (SHR) have been proposed as an animal model of attention-deficit hyperactivity disorder and show marked alterations of dopaminergic regulation of behaviour. SHR showed significantly lower startle amplitude than Wistar-Kyoto (WKY) rats and Sprague-Dawley (SD) rats, but no difference in startle habituation. Baseline percentage prepulse inhibition was higher in SHR and WKY rats than in SD rats. Treatment with amphetamine caused significant disruption of prepulse inhibition in SHR and WKY rats, but not SD rats. In contrast, treatment with apomorphine caused prepulse-dependent disruption of prepulse inhibition in SD rats only. Both MK-801 and 8-OH-DPAT treatment caused disruption of prepulse inhibition in all three rat strains. This study shows differential changes in startle level and prepulse inhibition in SHR, however these rats are not uniformly different from either WKY rats or SD rats and WKY rats differ in a number of respects from SD rats. In conclusion, these data further reveal altered dopaminergic regulation of behaviour in SHR, but also shows that caution is needed about the control strain used to compare these animals with. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15313020/Prepulse_inhibition_of_acoustic_startle_in_spontaneously_hypertensive_rats_ DB - PRIME DP - Unbound Medicine ER -