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Acoustic startle response, prepulse inhibition, and spontaneous locomotor activity in MPTP-treated mice.
Behav Brain Res. 2004 Oct 05; 154(2):449-56.BB

Abstract

Parkinson's disease (PD) is marked by characterised motor deficits and is accompanied by a severe degeneration of the nigrostriatal dopamine (DA) pathway. It has also been reported that PD patients exhibited additional behavioural deficits, including a deficiency in sensorimotor gating mechanisms. We therefore examined whether the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice could lead to a sensorimotor gating deficit in the prepulse inhibition (PPI) of the acoustic startle response (ASR) paradigm. Two MPTP treatment schedules were separately examined here in male C57BL/6 mice. Post-mortem HPLC analysis confirmed that they were effective in depleting DA in the dorsal striatum (75-88%). PPI was evaluated on days 2, 9 and 16 after the last MPTP treatment; spontaneous locomotor activity was assessed 24 h before each PPI test. No significant change in the expression of PPI was detected across the three time points. On the other hand, the MPTP treatment reduced activity on post-treatment day 1. This effect subsided on post-treatment day 8, and was reversed on day 15. The possibility remains therefore that the reported sensorimotor gating deficits in PD patients might stem from structural or neurochemical aberrations beyond those induced by MPTP treatment.

Authors+Show Affiliations

Laboratory of Behavioural Neurobiology, Swiss Federal Institute of Technology Zurich, Schorenstrasse 16, CH-8603 Schwerzenbach, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15313033

Citation

Leng, Andreas, et al. "Acoustic Startle Response, Prepulse Inhibition, and Spontaneous Locomotor Activity in MPTP-treated Mice." Behavioural Brain Research, vol. 154, no. 2, 2004, pp. 449-56.
Leng A, Yee BK, Feldon J, et al. Acoustic startle response, prepulse inhibition, and spontaneous locomotor activity in MPTP-treated mice. Behav Brain Res. 2004;154(2):449-56.
Leng, A., Yee, B. K., Feldon, J., & Ferger, B. (2004). Acoustic startle response, prepulse inhibition, and spontaneous locomotor activity in MPTP-treated mice. Behavioural Brain Research, 154(2), 449-56.
Leng A, et al. Acoustic Startle Response, Prepulse Inhibition, and Spontaneous Locomotor Activity in MPTP-treated Mice. Behav Brain Res. 2004 Oct 5;154(2):449-56. PubMed PMID: 15313033.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acoustic startle response, prepulse inhibition, and spontaneous locomotor activity in MPTP-treated mice. AU - Leng,Andreas, AU - Yee,Benjamin K, AU - Feldon,Joram, AU - Ferger,Boris, PY - 2003/12/19/received PY - 2004/03/12/revised PY - 2004/03/15/accepted PY - 2004/8/18/pubmed PY - 2004/11/2/medline PY - 2004/8/18/entrez SP - 449 EP - 56 JF - Behavioural brain research JO - Behav. Brain Res. VL - 154 IS - 2 N2 - Parkinson's disease (PD) is marked by characterised motor deficits and is accompanied by a severe degeneration of the nigrostriatal dopamine (DA) pathway. It has also been reported that PD patients exhibited additional behavioural deficits, including a deficiency in sensorimotor gating mechanisms. We therefore examined whether the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice could lead to a sensorimotor gating deficit in the prepulse inhibition (PPI) of the acoustic startle response (ASR) paradigm. Two MPTP treatment schedules were separately examined here in male C57BL/6 mice. Post-mortem HPLC analysis confirmed that they were effective in depleting DA in the dorsal striatum (75-88%). PPI was evaluated on days 2, 9 and 16 after the last MPTP treatment; spontaneous locomotor activity was assessed 24 h before each PPI test. No significant change in the expression of PPI was detected across the three time points. On the other hand, the MPTP treatment reduced activity on post-treatment day 1. This effect subsided on post-treatment day 8, and was reversed on day 15. The possibility remains therefore that the reported sensorimotor gating deficits in PD patients might stem from structural or neurochemical aberrations beyond those induced by MPTP treatment. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15313033/Acoustic_startle_response_prepulse_inhibition_and_spontaneous_locomotor_activity_in_MPTP_treated_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166432804000956 DB - PRIME DP - Unbound Medicine ER -