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Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats.
Clin Chim Acta 2004; 347(1-2):121-8CC

Abstract

BACKGROUND

Water extract of Pueraria radix (PRWE), traditional oriental medicinal plant, may have an effect on the activity of hepatic antioxidant enzymes and lipid profile in ethanol-treated rats.

METHODS

Male Sprague-Dawley rats were divided into control, ethanol, PRWE and ethanol-PRWE supplemented groups. Twenty-five percent (v/v) ethanol (5 g/kg body weight) was orally administered once a day for 5 weeks. The PRWE was supplemented in a diet based on 1500 mg of raw PRWE/kg body weight/day.

RESULTS

Ethanol feeding resulted in a higher alcohol dehydrogenase (ADH) activity and lower aldehyde dehydrogenase (ALDH) activity. After PRWE supplementation, both activities were increased. The PRWE supplementation resulted in a significant decrease in the plasma and liver total cholesterol concentrations in the ethanol-treated rats. Ethanol administration significantly lowered the activities of hepatic superoxide dismutase (SOD) and catalase (CAT), whereas it increased the plasma and hepatic thiobarbituric acid reactive substances (TBARS) and the hepatic glutathione peroxidase (GSH-Px) activities. However, PRWE supplementation resulted in a significant increase in the SOD and CAT activities and a significant decrease in the TBARS and the GSH-Px activities in the ethanol-treated rats.

CONCLUSION

PRWE can contribute to alleviating the adverse effect of ethanol ingestion by enhancing the lipid metabolism as well as the hepatic antioxidant defense system.

Authors+Show Affiliations

Department of Food and Nutrition, Kosin University, Busan 606-701, South Korea. jslee@Kosin.ac.kr

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15313149

Citation

Lee, Jeong-Sook. "Supplementation of Pueraria Radix Water Extract On Changes of Antioxidant Enzymes and Lipid Profile in Ethanol-treated Rats." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 347, no. 1-2, 2004, pp. 121-8.
Lee JS. Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats. Clin Chim Acta. 2004;347(1-2):121-8.
Lee, J. S. (2004). Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats. Clinica Chimica Acta; International Journal of Clinical Chemistry, 347(1-2), pp. 121-8.
Lee JS. Supplementation of Pueraria Radix Water Extract On Changes of Antioxidant Enzymes and Lipid Profile in Ethanol-treated Rats. Clin Chim Acta. 2004;347(1-2):121-8. PubMed PMID: 15313149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation of Pueraria radix water extract on changes of antioxidant enzymes and lipid profile in ethanol-treated rats. A1 - Lee,Jeong-Sook, PY - 2003/12/23/received PY - 2004/04/13/revised PY - 2004/04/14/accepted PY - 2004/8/18/pubmed PY - 2004/12/24/medline PY - 2004/8/18/entrez SP - 121 EP - 8 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 347 IS - 1-2 N2 - BACKGROUND: Water extract of Pueraria radix (PRWE), traditional oriental medicinal plant, may have an effect on the activity of hepatic antioxidant enzymes and lipid profile in ethanol-treated rats. METHODS: Male Sprague-Dawley rats were divided into control, ethanol, PRWE and ethanol-PRWE supplemented groups. Twenty-five percent (v/v) ethanol (5 g/kg body weight) was orally administered once a day for 5 weeks. The PRWE was supplemented in a diet based on 1500 mg of raw PRWE/kg body weight/day. RESULTS: Ethanol feeding resulted in a higher alcohol dehydrogenase (ADH) activity and lower aldehyde dehydrogenase (ALDH) activity. After PRWE supplementation, both activities were increased. The PRWE supplementation resulted in a significant decrease in the plasma and liver total cholesterol concentrations in the ethanol-treated rats. Ethanol administration significantly lowered the activities of hepatic superoxide dismutase (SOD) and catalase (CAT), whereas it increased the plasma and hepatic thiobarbituric acid reactive substances (TBARS) and the hepatic glutathione peroxidase (GSH-Px) activities. However, PRWE supplementation resulted in a significant increase in the SOD and CAT activities and a significant decrease in the TBARS and the GSH-Px activities in the ethanol-treated rats. CONCLUSION: PRWE can contribute to alleviating the adverse effect of ethanol ingestion by enhancing the lipid metabolism as well as the hepatic antioxidant defense system. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15313149/Supplementation_of_Pueraria_radix_water_extract_on_changes_of_antioxidant_enzymes_and_lipid_profile_in_ethanol_treated_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009898104001998 DB - PRIME DP - Unbound Medicine ER -