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Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults.
Clin Chim Acta 2004; 347(1-2):139-44CC

Abstract

BACKGROUND

Coenzyme Q10 (CoQ) is an endogenous enzyme cofactor, which may provide protective benefits as an antioxidant. Because age-related CoQ changes and deficiency states have been described, there is a need to establish normal ranges in healthy children. The objectives of this study are to determine if age-related differences in reduced CoQ (ubiquinol), oxidized CoQ (ubiquinone), and CoQ redox state exist in childhood, and to establish reference intervals for these analytes in healthy children.

METHODS

Apparently healthy children (n=68) were selected from individuals with no history of current acute illness, medically diagnosed disease, or current medication treatment. Self-reported healthy adults (n=106) were selected from the ongoing Princeton Follow-up Study in greater Cincinnati. Participants were assessed for lipid profiles, ubiquinol concentration, ubiquinone concentration, total CoQ concentration, and CoQ redox ratio.

RESULTS

Mean total CoQ and ubiquinol concentrations are similar in younger children (0.2-7.6 years) and adults (29-78 years); however, lipid-adjusted total CoQ concentrations are significantly increased in younger children. Also CoQ redox ratio is significantly increased in younger and older children compared with adults.

CONCLUSIONS

Elevated CoQ and redox ratios in children may be an indication of oxidative stress effects, which are associated with early development of coronary heart disease.

Authors+Show Affiliations

Divisions of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. michael.miles@cchmc.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15313151

Citation

Miles, Michael V., et al. "Age-related Changes in Plasma Coenzyme Q10 Concentrations and Redox State in Apparently Healthy Children and Adults." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 347, no. 1-2, 2004, pp. 139-44.
Miles MV, Horn PS, Tang PH, et al. Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults. Clin Chim Acta. 2004;347(1-2):139-44.
Miles, M. V., Horn, P. S., Tang, P. H., Morrison, J. A., Miles, L., DeGrauw, T., & Pesce, A. J. (2004). Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults. Clinica Chimica Acta; International Journal of Clinical Chemistry, 347(1-2), pp. 139-44.
Miles MV, et al. Age-related Changes in Plasma Coenzyme Q10 Concentrations and Redox State in Apparently Healthy Children and Adults. Clin Chim Acta. 2004;347(1-2):139-44. PubMed PMID: 15313151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults. AU - Miles,Michael V, AU - Horn,Paul S, AU - Tang,Peter H, AU - Morrison,John A, AU - Miles,Lili, AU - DeGrauw,Ton, AU - Pesce,Amadeo J, PY - 2004/02/21/received PY - 2004/04/13/revised PY - 2004/04/14/accepted PY - 2004/8/18/pubmed PY - 2004/12/24/medline PY - 2004/8/18/entrez SP - 139 EP - 44 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 347 IS - 1-2 N2 - BACKGROUND: Coenzyme Q10 (CoQ) is an endogenous enzyme cofactor, which may provide protective benefits as an antioxidant. Because age-related CoQ changes and deficiency states have been described, there is a need to establish normal ranges in healthy children. The objectives of this study are to determine if age-related differences in reduced CoQ (ubiquinol), oxidized CoQ (ubiquinone), and CoQ redox state exist in childhood, and to establish reference intervals for these analytes in healthy children. METHODS: Apparently healthy children (n=68) were selected from individuals with no history of current acute illness, medically diagnosed disease, or current medication treatment. Self-reported healthy adults (n=106) were selected from the ongoing Princeton Follow-up Study in greater Cincinnati. Participants were assessed for lipid profiles, ubiquinol concentration, ubiquinone concentration, total CoQ concentration, and CoQ redox ratio. RESULTS: Mean total CoQ and ubiquinol concentrations are similar in younger children (0.2-7.6 years) and adults (29-78 years); however, lipid-adjusted total CoQ concentrations are significantly increased in younger children. Also CoQ redox ratio is significantly increased in younger and older children compared with adults. CONCLUSIONS: Elevated CoQ and redox ratios in children may be an indication of oxidative stress effects, which are associated with early development of coronary heart disease. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15313151/Age_related_changes_in_plasma_coenzyme_Q10_concentrations_and_redox_state_in_apparently_healthy_children_and_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009898104002001 DB - PRIME DP - Unbound Medicine ER -