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Composition and biological activity of traditional and commercial kava extracts.
Biochem Biophys Res Commun. 2004 Sep 10; 322(1):147-52.BB

Abstract

For centuries the South Pacific islanders have consumed kava (Piper methysticum) as a ceremonial intoxicating beverage. More recently, caplets of kava extracts have been commercialized for their anxiolytic and antidepressant activities. Several cases of hepatotoxicity have been reported following consumption of the commercial preparation whereas no serious health effects had been documented for the traditional beverage. A detailed comparison of commercial kava extracts (prepared in acetone, ethanol or methanol) and traditional kava (aqueous) reveals significant differences in the ratio of the major kavalactones. To show that these variations could lead to differences in biological activity, the extracts were compared for their inhibition of the major drug metabolizing P450 enzymes. In all cases (CYP3A4, CYP1A2, CYP2C9, and CYP2C19), the inhibition was more pronounced for the commercial preparation. Our results suggest that the variations in health effects reported for the kava extracts may result from the different preparation protocols used.

Authors+Show Affiliations

Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montréal, Que., Canada H3A 2K6.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15313185

Citation

Côté, Cynthia S., et al. "Composition and Biological Activity of Traditional and Commercial Kava Extracts." Biochemical and Biophysical Research Communications, vol. 322, no. 1, 2004, pp. 147-52.
Côté CS, Kor C, Cohen J, et al. Composition and biological activity of traditional and commercial kava extracts. Biochem Biophys Res Commun. 2004;322(1):147-52.
Côté, C. S., Kor, C., Cohen, J., & Auclair, K. (2004). Composition and biological activity of traditional and commercial kava extracts. Biochemical and Biophysical Research Communications, 322(1), 147-52.
Côté CS, et al. Composition and Biological Activity of Traditional and Commercial Kava Extracts. Biochem Biophys Res Commun. 2004 Sep 10;322(1):147-52. PubMed PMID: 15313185.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Composition and biological activity of traditional and commercial kava extracts. AU - Côté,Cynthia S, AU - Kor,Christine, AU - Cohen,Jon, AU - Auclair,Karine, PY - 2004/07/02/received PY - 2004/8/18/pubmed PY - 2004/10/2/medline PY - 2004/8/18/entrez SP - 147 EP - 52 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 322 IS - 1 N2 - For centuries the South Pacific islanders have consumed kava (Piper methysticum) as a ceremonial intoxicating beverage. More recently, caplets of kava extracts have been commercialized for their anxiolytic and antidepressant activities. Several cases of hepatotoxicity have been reported following consumption of the commercial preparation whereas no serious health effects had been documented for the traditional beverage. A detailed comparison of commercial kava extracts (prepared in acetone, ethanol or methanol) and traditional kava (aqueous) reveals significant differences in the ratio of the major kavalactones. To show that these variations could lead to differences in biological activity, the extracts were compared for their inhibition of the major drug metabolizing P450 enzymes. In all cases (CYP3A4, CYP1A2, CYP2C9, and CYP2C19), the inhibition was more pronounced for the commercial preparation. Our results suggest that the variations in health effects reported for the kava extracts may result from the different preparation protocols used. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/15313185/Composition_and_biological_activity_of_traditional_and_commercial_kava_extracts_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(04)01597-9 DB - PRIME DP - Unbound Medicine ER -