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Breast-feeding and childhood obesity--a systematic review.
Int J Obes Relat Metab Disord 2004; 28(10):1247-56IJ

Abstract

OBJECTIVE

To investigate the relationship between breast-feeding and obesity in childhood.

DESIGN

Systematic review and meta-analysis of published epidemiological studies (cohort, case-control or cross-sectional studies) comparing early feeding-mode and adjusting for potential confounding factors. Electronic databases were searched and reference lists of relevant articles were checked. Calculations of pooled estimates were conducted in fixed- and random-effects models. Heterogeneity was tested by Q-test. Publication bias was assessed from funnel plots and by a linear regression method.

OUTCOME MEASURES

Odds ratio (OR) for obesity in childhood defined as body mass index (BMI) percentiles.

RESULTS

Nine studies with more than 69,000 participants met the inclusion criteria. The meta-analysis showed that breast-feeding reduced the risk of obesity in childhood significantly. The adjusted odds ratio was 0.78, 95% CI (0.71, 0.85) in the fixed model. The assumption of homogeneity of results of the included studies could not be refuted (Q-test for heterogeneity, P>0.3), stratified analyses showed no differences regarding different study types, age groups, definition of breast-feeding or obesity and number of confounding factors adjusted for. A dose-dependent effect of breast-feeding duration on the prevalence of obesity was reported in four studies. Funnel plot regression gave no indication of publication bias.

CONCLUSION

Breast-feeding seems to have a small but consistent protective effect against obesity in children.

Authors+Show Affiliations

Institute for Social Paediatrics and Adolescent Medicine, Ludwig-Maximilians University, D-81377 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

15314625

Citation

Arenz, S, et al. "Breast-feeding and Childhood Obesity--a Systematic Review." International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, vol. 28, no. 10, 2004, pp. 1247-56.
Arenz S, Rückerl R, Koletzko B, et al. Breast-feeding and childhood obesity--a systematic review. Int J Obes Relat Metab Disord. 2004;28(10):1247-56.
Arenz, S., Rückerl, R., Koletzko, B., & von Kries, R. (2004). Breast-feeding and childhood obesity--a systematic review. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 28(10), pp. 1247-56.
Arenz S, et al. Breast-feeding and Childhood Obesity--a Systematic Review. Int J Obes Relat Metab Disord. 2004;28(10):1247-56. PubMed PMID: 15314625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast-feeding and childhood obesity--a systematic review. AU - Arenz,S, AU - Rückerl,R, AU - Koletzko,B, AU - von Kries,R, PY - 2004/8/18/pubmed PY - 2004/10/27/medline PY - 2004/8/18/entrez SP - 1247 EP - 56 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity JO - Int. J. Obes. Relat. Metab. Disord. VL - 28 IS - 10 N2 - OBJECTIVE: To investigate the relationship between breast-feeding and obesity in childhood. DESIGN: Systematic review and meta-analysis of published epidemiological studies (cohort, case-control or cross-sectional studies) comparing early feeding-mode and adjusting for potential confounding factors. Electronic databases were searched and reference lists of relevant articles were checked. Calculations of pooled estimates were conducted in fixed- and random-effects models. Heterogeneity was tested by Q-test. Publication bias was assessed from funnel plots and by a linear regression method. OUTCOME MEASURES: Odds ratio (OR) for obesity in childhood defined as body mass index (BMI) percentiles. RESULTS: Nine studies with more than 69,000 participants met the inclusion criteria. The meta-analysis showed that breast-feeding reduced the risk of obesity in childhood significantly. The adjusted odds ratio was 0.78, 95% CI (0.71, 0.85) in the fixed model. The assumption of homogeneity of results of the included studies could not be refuted (Q-test for heterogeneity, P>0.3), stratified analyses showed no differences regarding different study types, age groups, definition of breast-feeding or obesity and number of confounding factors adjusted for. A dose-dependent effect of breast-feeding duration on the prevalence of obesity was reported in four studies. Funnel plot regression gave no indication of publication bias. CONCLUSION: Breast-feeding seems to have a small but consistent protective effect against obesity in children. UR - https://www.unboundmedicine.com/medline/citation/15314625/Breast_feeding_and_childhood_obesity__a_systematic_review_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15314625.ui DB - PRIME DP - Unbound Medicine ER -