Tags

Type your tag names separated by a space and hit enter

Immunomodulating effects of "tien-hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations.
Am J Chin Med. 2004; 32(2):221-34.AJ

Abstract

Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. In our institution, an immunomodulating agent, levamisole, is used to treat RAU with satisfactory therapeutic effect. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. To test whether THL has immunomodulating effects on antigen-stimulated proliferation response (PR) of peripheral blood mononuclear cells (PBMC) and T-cells isolated from RAU patients and to test whether THL is a potential drug for treating RAU, PBMC or T-cells isolated from RAU patients were incubated with lipopolysaccharides (LPS) from Escherica coli, phytohemagglutinin (PHA), staphylococcal enterotoxin B (SEB), glutaraldehyde-inactivated tetanus toxoid (TT), glucosyltransferase D (GtfD), or antigens of Streptococcus mutans in the presence or absence of THL. We found that THL significantly increased the LPS-stimulated PR of PBMC from active RAU patients, the GtfD-stimulated PR of PBMC and of T-cells from inactive RAU patients, and the S. mutans-stimulated PR of PBMC from inactive RAU patients. However, THL could also significantly reduce the SEB-stimulated PR of PBMC and of T-cells from active RAU patients and S. mutans-stimulated PR of T-cells from active RAU patients. These results suggest that THL can modulate the antigen-stimulated PR of PBMC and T-cells from RAU patients. Therefore, it may be a potential immunoceutical agent for treatment of RAU.

Authors+Show Affiliations

School of Dentistry and Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15315260

Citation

Sun, Andy, et al. "Immunomodulating Effects of "tien-hsien Liquid" On Peripheral Blood Mononuclear Cells and T-lymphocytes From Patients With Recurrent Aphthous Ulcerations." The American Journal of Chinese Medicine, vol. 32, no. 2, 2004, pp. 221-34.
Sun A, Chia JS, Wang WB, et al. Immunomodulating effects of "tien-hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations. Am J Chin Med. 2004;32(2):221-34.
Sun, A., Chia, J. S., Wang, W. B., & Chiang, C. P. (2004). Immunomodulating effects of "tien-hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations. The American Journal of Chinese Medicine, 32(2), 221-34.
Sun A, et al. Immunomodulating Effects of "tien-hsien Liquid" On Peripheral Blood Mononuclear Cells and T-lymphocytes From Patients With Recurrent Aphthous Ulcerations. Am J Chin Med. 2004;32(2):221-34. PubMed PMID: 15315260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunomodulating effects of "tien-hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations. AU - Sun,Andy, AU - Chia,Jean-San, AU - Wang,Won-Bo, AU - Chiang,Chun-Pin, PY - 2004/8/19/pubmed PY - 2004/11/4/medline PY - 2004/8/19/entrez SP - 221 EP - 34 JF - The American journal of Chinese medicine JO - Am J Chin Med VL - 32 IS - 2 N2 - Recurrent aphthous ulcerations (RAU) represent a common oral mucosal disease with altered humoral and cellular immunities. In our institution, an immunomodulating agent, levamisole, is used to treat RAU with satisfactory therapeutic effect. Tien-Hsien liquid (THL) is an extract of Chinese medicinal herbs with immunomodulating effects. To test whether THL has immunomodulating effects on antigen-stimulated proliferation response (PR) of peripheral blood mononuclear cells (PBMC) and T-cells isolated from RAU patients and to test whether THL is a potential drug for treating RAU, PBMC or T-cells isolated from RAU patients were incubated with lipopolysaccharides (LPS) from Escherica coli, phytohemagglutinin (PHA), staphylococcal enterotoxin B (SEB), glutaraldehyde-inactivated tetanus toxoid (TT), glucosyltransferase D (GtfD), or antigens of Streptococcus mutans in the presence or absence of THL. We found that THL significantly increased the LPS-stimulated PR of PBMC from active RAU patients, the GtfD-stimulated PR of PBMC and of T-cells from inactive RAU patients, and the S. mutans-stimulated PR of PBMC from inactive RAU patients. However, THL could also significantly reduce the SEB-stimulated PR of PBMC and of T-cells from active RAU patients and S. mutans-stimulated PR of T-cells from active RAU patients. These results suggest that THL can modulate the antigen-stimulated PR of PBMC and T-cells from RAU patients. Therefore, it may be a potential immunoceutical agent for treatment of RAU. SN - 0192-415X UR - https://www.unboundmedicine.com/medline/citation/15315260/Immunomodulating_effects_of_"tien_hsien_liquid"_on_peripheral_blood_mononuclear_cells_and_T_lymphocytes_from_patients_with_recurrent_aphthous_ulcerations_ L2 - https://www.worldscientific.com/doi/10.1142/S0192415X04001886?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -