Tags

Type your tag names separated by a space and hit enter

In utero exposure to polychlorinated biphenyls and sensorineural hearing loss in 8-year-old children.
Neurotoxicol Teratol. 2004 Sep-Oct; 26(5):629-37.NT

Abstract

Early-life exposure to polychlorinated biphenyls (PCBs), a ubiquitous environmental contaminant, increases the hearing threshold at selected frequencies in rats. Among humans from the Faroe Islands with unusually high early-life PCB exposure, exposure was directly associated with increased hearing thresholds at two frequencies, although the deficits were present in the left ear but not the right. We examined PCB levels in maternal pregnancy serum in relation with audiometrically determined hearing thresholds among offspring when they were of school age. Complete data were available for 195 children with sensorineural hearing loss (SNHL) and 615 children selected at random, all of whom were born in 1959-1966 in the Collaborative Perinatal Project (CPP) U.S. cohort. The median exposure among those selected at random, as reflected by the mother's third trimester serum total PCB concentration, was 2.8 microg/l, about twofold higher than recent background levels in the United States. Based on the average hearing threshold across the frequencies essential for speech recognition in the "worst ear," the maternal serum PCB level was unrelated to the adjusted odds of SNHL or to adjusted mean hearing threshold. Overall, an adverse effect of early-life, background-level PCB exposure on SNHL was not supported by these data.

Authors+Show Affiliations

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA. longnecker@niehs.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15315812

Citation

Longnecker, Matthew P., et al. "In Utero Exposure to Polychlorinated Biphenyls and Sensorineural Hearing Loss in 8-year-old Children." Neurotoxicology and Teratology, vol. 26, no. 5, 2004, pp. 629-37.
Longnecker MP, Hoffman HJ, Klebanoff MA, et al. In utero exposure to polychlorinated biphenyls and sensorineural hearing loss in 8-year-old children. Neurotoxicol Teratol. 2004;26(5):629-37.
Longnecker, M. P., Hoffman, H. J., Klebanoff, M. A., Brock, J. W., Zhou, H., Needham, L., Adera, T., Guo, X., & Gray, K. A. (2004). In utero exposure to polychlorinated biphenyls and sensorineural hearing loss in 8-year-old children. Neurotoxicology and Teratology, 26(5), 629-37.
Longnecker MP, et al. In Utero Exposure to Polychlorinated Biphenyls and Sensorineural Hearing Loss in 8-year-old Children. Neurotoxicol Teratol. 2004 Sep-Oct;26(5):629-37. PubMed PMID: 15315812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In utero exposure to polychlorinated biphenyls and sensorineural hearing loss in 8-year-old children. AU - Longnecker,Matthew P, AU - Hoffman,Howard J, AU - Klebanoff,Mark A, AU - Brock,John W, AU - Zhou,Haibo, AU - Needham,Larry, AU - Adera,Tilahun, AU - Guo,Xuguang, AU - Gray,Kimberly A, PY - 2004/03/15/received PY - 2004/04/20/revised PY - 2004/04/26/accepted PY - 2004/8/19/pubmed PY - 2004/11/13/medline PY - 2004/8/19/entrez SP - 629 EP - 37 JF - Neurotoxicology and teratology JO - Neurotoxicol Teratol VL - 26 IS - 5 N2 - Early-life exposure to polychlorinated biphenyls (PCBs), a ubiquitous environmental contaminant, increases the hearing threshold at selected frequencies in rats. Among humans from the Faroe Islands with unusually high early-life PCB exposure, exposure was directly associated with increased hearing thresholds at two frequencies, although the deficits were present in the left ear but not the right. We examined PCB levels in maternal pregnancy serum in relation with audiometrically determined hearing thresholds among offspring when they were of school age. Complete data were available for 195 children with sensorineural hearing loss (SNHL) and 615 children selected at random, all of whom were born in 1959-1966 in the Collaborative Perinatal Project (CPP) U.S. cohort. The median exposure among those selected at random, as reflected by the mother's third trimester serum total PCB concentration, was 2.8 microg/l, about twofold higher than recent background levels in the United States. Based on the average hearing threshold across the frequencies essential for speech recognition in the "worst ear," the maternal serum PCB level was unrelated to the adjusted odds of SNHL or to adjusted mean hearing threshold. Overall, an adverse effect of early-life, background-level PCB exposure on SNHL was not supported by these data. SN - 0892-0362 UR - https://www.unboundmedicine.com/medline/citation/15315812/In_utero_exposure_to_polychlorinated_biphenyls_and_sensorineural_hearing_loss_in_8_year_old_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0892036204000698 DB - PRIME DP - Unbound Medicine ER -