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Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women.
Med Princ Pract. 2004 Sep-Oct; 13(5):260-6.MP

Abstract

OBJECTIVE

Vitamin D receptor (VDR) gene polymorphisms and bone metabolic markers were investigated as potential genetic markers for osteoporosis in postmenopausal Turkish women. The relationship between their VDR gene polymorphisms and bone states was determined.

MATERIALS AND METHODS

Restriction fragment length polymorphisms at the VDR gene locus (i.e., for BsmI, ApaI, and TaqI) was investigated in 75 postmenopausal osteoporotic (53.16 +/- 1.31 years) and 66 healthy (52.62 +/- 1.69 years) Turkish women and the genotypes were related to bone mineral density (BMD) at femoral neck (FN), lumbar spine (L1-4), trochanter, Ward's triangle (Ward's) and metabolic parameters of bone turnover.

RESULTS

In osteoporotic women, TaqI genotype-related differences of the VDR gene were found to be significant at all BMD sites; TT genotype had higher L1-4 BMD values than Tt and tt (p < 0.05); tt genotype had significantly lower BMD at FN (p < 0.05), trochanter (p < 0.01), and Ward's (p < 0.05) compared to TT genotype. The tt genotype was found to be associated with higher (p < 0.05) serum osteocalcin levels compared to Tt and TT genotypes in the osteoporotic women, whereas no such association was found for the healthy women.

CONCLUSION

Our data showed an association between VDR TaqI genotype and BMD at the FN, L1-4, trochanter and Ward's triangle in nonobese postmenopausal osteoporotic women. Thus the VDR gene Taql polymorphism modulates differences in BMD in the postmenopausal osteoporotic women.

Authors+Show Affiliations

Duman BS
Department of Medical Biology and Genetics, Kadir Has University Medical Faculty, Gayrettepe-Istanbul, Turkey.
Tanakol R
No affiliation info available
Erensoy N
No affiliation info available
Oztürk M
No affiliation info available
Yilmazer S
No affiliation info available

MeSH

Body Mass IndexBone DensityBone RemodelingCalciumCase-Control StudiesDeoxyribonucleases, Type II Site-SpecificFemaleGenotypeHumansHydroxyprolineOsteocalcinOsteoporosis, PostmenopausalPolymorphism, Restriction Fragment LengthReceptors, CalcitriolTurkey

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15316258

Citation

Duman, Belgin Süsleyici, et al. "Vitamin D Receptor Alleles, Bone Mineral Density and Turnover in Postmenopausal Osteoporotic and Healthy Women." Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, vol. 13, no. 5, 2004, pp. 260-6.
Duman BS, Tanakol R, Erensoy N, et al. Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women. Med Princ Pract. 2004;13(5):260-6.
Duman, B. S., Tanakol, R., Erensoy, N., Oztürk, M., & Yilmazer, S. (2004). Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women. Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre, 13(5), 260-6.
Duman BS, et al. Vitamin D Receptor Alleles, Bone Mineral Density and Turnover in Postmenopausal Osteoporotic and Healthy Women. Med Princ Pract. 2004 Sep-Oct;13(5):260-6. PubMed PMID: 15316258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women. AU - Duman,Belgin Süsleyici, AU - Tanakol,Refik, AU - Erensoy,Nevin, AU - Oztürk,Melek, AU - Yilmazer,Selma, PY - 2003/01/20/received PY - 2003/06/28/accepted PY - 2004/8/19/pubmed PY - 2005/1/26/medline PY - 2004/8/19/entrez SP - 260 EP - 6 JF - Medical principles and practice : international journal of the Kuwait University, Health Science Centre JO - Med Princ Pract VL - 13 IS - 5 N2 - OBJECTIVE: Vitamin D receptor (VDR) gene polymorphisms and bone metabolic markers were investigated as potential genetic markers for osteoporosis in postmenopausal Turkish women. The relationship between their VDR gene polymorphisms and bone states was determined. MATERIALS AND METHODS: Restriction fragment length polymorphisms at the VDR gene locus (i.e., for BsmI, ApaI, and TaqI) was investigated in 75 postmenopausal osteoporotic (53.16 +/- 1.31 years) and 66 healthy (52.62 +/- 1.69 years) Turkish women and the genotypes were related to bone mineral density (BMD) at femoral neck (FN), lumbar spine (L1-4), trochanter, Ward's triangle (Ward's) and metabolic parameters of bone turnover. RESULTS: In osteoporotic women, TaqI genotype-related differences of the VDR gene were found to be significant at all BMD sites; TT genotype had higher L1-4 BMD values than Tt and tt (p < 0.05); tt genotype had significantly lower BMD at FN (p < 0.05), trochanter (p < 0.01), and Ward's (p < 0.05) compared to TT genotype. The tt genotype was found to be associated with higher (p < 0.05) serum osteocalcin levels compared to Tt and TT genotypes in the osteoporotic women, whereas no such association was found for the healthy women. CONCLUSION: Our data showed an association between VDR TaqI genotype and BMD at the FN, L1-4, trochanter and Ward's triangle in nonobese postmenopausal osteoporotic women. Thus the VDR gene Taql polymorphism modulates differences in BMD in the postmenopausal osteoporotic women. SN - 1011-7571 UR - https://www.unboundmedicine.com/medline/citation/15316258/Vitamin_D_receptor_alleles_bone_mineral_density_and_turnover_in_postmenopausal_osteoporotic_and_healthy_women_ DB - PRIME DP - Unbound Medicine ER -