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Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep.
Eur J Appl Physiol. 2004 Oct; 93(1-2):190-5.EJ

Abstract

Nitric oxide (NO) is important for the pulmonary circulation response to acute and chronic hypoxia. We examined effects of endogenous nitric oxide synthase (NOS) inhibition on pulmonary vascular tone in response to hypoxia in Tibetan sheep dwelling at 3,000 m above sea level using a pressure chamber. Unanaesthetized male sheep living at 2,300 m above sea level (n=7) were prepared for vascular monitoring. Pulmonary artery (P(pa)), pulmonary artery wedge (P(cwp)) and systemic artery pressures together with cardiac output (CO) were measured, and pulmonary vascular resistance (PVR) was calculated as (P(pa)- P(cwp))/CO. A non-selective NOS inhibitor, N(omega)-nitro- l-arginine (NLA; 20 mg kg(-1)), and a selective NOS inhibitor, ONO-1714 (0.1 mg kg(-1)), were used and measurements were made at 0 m, 2,300 m, and 4,500 m, with and without the NOS inhibitors. After NLA, P(pa) increased slightly and CO decreased in animals at baseline (2,300 m). The increased PVR after NLA at 4,500 m was greater than that at 2,300 m (P<0.05). Selective NOS inhibition increased PVR at baseline, but not at 4,500 m. The enhanced pulmonary vasoconstriction after NO inhibition at basal and hypoxic conditions suggests a modulating role of NOS bioactivity in the pulmonary circulation and that augmented endothelial NOS plays a counterregulatory role in the pulmonary vasoconstrictor response to acute hypoxia in high-altitude adapted Tibetan sheep.

Authors+Show Affiliations

First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, 390-8621 Nagano, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15316790

Citation

Ruan, Zonghai, et al. "Endogenous Nitric Oxide and Pulmonary Circulation Response to Hypoxia in High-altitude Adapted Tibetan Sheep." European Journal of Applied Physiology, vol. 93, no. 1-2, 2004, pp. 190-5.
Ruan Z, Koizumi T, Sakai A, et al. Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep. Eur J Appl Physiol. 2004;93(1-2):190-5.
Ruan, Z., Koizumi, T., Sakai, A., Ishizaki, T., & Wang, Z. (2004). Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep. European Journal of Applied Physiology, 93(1-2), 190-5.
Ruan Z, et al. Endogenous Nitric Oxide and Pulmonary Circulation Response to Hypoxia in High-altitude Adapted Tibetan Sheep. Eur J Appl Physiol. 2004;93(1-2):190-5. PubMed PMID: 15316790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous nitric oxide and pulmonary circulation response to hypoxia in high-altitude adapted Tibetan sheep. AU - Ruan,Zonghai, AU - Koizumi,Tomonobu, AU - Sakai,Akio, AU - Ishizaki,Takeshi, AU - Wang,Zhangang, Y1 - 2004/08/14/ PY - 2004/07/01/accepted PY - 2004/8/19/pubmed PY - 2005/7/6/medline PY - 2004/8/19/entrez SP - 190 EP - 5 JF - European journal of applied physiology JO - Eur J Appl Physiol VL - 93 IS - 1-2 N2 - Nitric oxide (NO) is important for the pulmonary circulation response to acute and chronic hypoxia. We examined effects of endogenous nitric oxide synthase (NOS) inhibition on pulmonary vascular tone in response to hypoxia in Tibetan sheep dwelling at 3,000 m above sea level using a pressure chamber. Unanaesthetized male sheep living at 2,300 m above sea level (n=7) were prepared for vascular monitoring. Pulmonary artery (P(pa)), pulmonary artery wedge (P(cwp)) and systemic artery pressures together with cardiac output (CO) were measured, and pulmonary vascular resistance (PVR) was calculated as (P(pa)- P(cwp))/CO. A non-selective NOS inhibitor, N(omega)-nitro- l-arginine (NLA; 20 mg kg(-1)), and a selective NOS inhibitor, ONO-1714 (0.1 mg kg(-1)), were used and measurements were made at 0 m, 2,300 m, and 4,500 m, with and without the NOS inhibitors. After NLA, P(pa) increased slightly and CO decreased in animals at baseline (2,300 m). The increased PVR after NLA at 4,500 m was greater than that at 2,300 m (P<0.05). Selective NOS inhibition increased PVR at baseline, but not at 4,500 m. The enhanced pulmonary vasoconstriction after NO inhibition at basal and hypoxic conditions suggests a modulating role of NOS bioactivity in the pulmonary circulation and that augmented endothelial NOS plays a counterregulatory role in the pulmonary vasoconstrictor response to acute hypoxia in high-altitude adapted Tibetan sheep. SN - 1439-6319 UR - https://www.unboundmedicine.com/medline/citation/15316790/Endogenous_nitric_oxide_and_pulmonary_circulation_response_to_hypoxia_in_high_altitude_adapted_Tibetan_sheep_ L2 - https://dx.doi.org/10.1007/s00421-004-1197-z DB - PRIME DP - Unbound Medicine ER -