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Bone densitometry: which skeletal sites are best predicted by bone mass determinants?
J Bone Miner Metab. 2004; 22(5):447-55.JB

Abstract

Evaluation of bone mineral content/bone mass density (BMC/BMD) is important to determine bone mass development among adolescents in health and disease. It is uncertain at which skeletal site BMC/BMD is best predicted by bone mass determinants. On the other hand, intrapersonal BMC/BMD data can be clustered into a composite index score to facilitate correlation and outcome prediction analysis. This study aimed to identify the skeletal site that was best predicted by bone mass determinants and to develop a composite index score based on multisite BMC/BMD values in healthy adolescent girls. Eleven BMD/BMC variables per subject were evaluated by using dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) in 236 healthy girls aged 12-15 years. Bone mass determinants, namely, weight, height, puberty, dietary calcium, physical activity, and bone turnover markers, were determined. Factor analysis was used to develop composite index scores that summarized characteristics of multisite BMC/BMD. Results showed that lumbar spinal BMD and BMC (by DXA) and tibial integral BMD (by pQCT) were the BMC/BMD sites better predicted by bone mass determinants (R2, 0.57-0.77) in multiple regression analysis. On the other hand, three composite index scores representing areal BMD, areal BMC, and vBMD were derived to summarize the original BMC/BMD values. The composite index scores had similar predicting power (R2, 0.419-0.749) compared to those of original BMC/BMD, indicating that the composite index scores were representative of the original variables. To conclude, lumbar spinal BMD and BMC and tibial integral BMD were the three BMC/BMD variables better predicted by bone mass determinants. This evaluation would help select appropriate skeletal sites as outcome measures for bone mass evaluation in future studies. Also, the development of composite index scores could help reduce the number of variables for correlation and outcome prediction analyses.

Authors+Show Affiliations

Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, 5/F Clinical Sciences Building, Prince of Wales Hospital, Hong Kong, Shatin, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15316865

Citation

Lee, Warren T K., et al. "Bone Densitometry: Which Skeletal Sites Are Best Predicted By Bone Mass Determinants?" Journal of Bone and Mineral Metabolism, vol. 22, no. 5, 2004, pp. 447-55.
Lee WT, Cheung AY, Lau J, et al. Bone densitometry: which skeletal sites are best predicted by bone mass determinants? J Bone Miner Metab. 2004;22(5):447-55.
Lee, W. T., Cheung, A. Y., Lau, J., Lee, S. K., Qin, L., & Cheng, J. C. (2004). Bone densitometry: which skeletal sites are best predicted by bone mass determinants? Journal of Bone and Mineral Metabolism, 22(5), 447-55.
Lee WT, et al. Bone Densitometry: Which Skeletal Sites Are Best Predicted By Bone Mass Determinants. J Bone Miner Metab. 2004;22(5):447-55. PubMed PMID: 15316865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bone densitometry: which skeletal sites are best predicted by bone mass determinants? AU - Lee,Warren T K, AU - Cheung,Albert Y K, AU - Lau,Joseph, AU - Lee,Simon K M, AU - Qin,Ling, AU - Cheng,Jack C Y, PY - 2003/12/16/received PY - 2004/02/27/accepted PY - 2004/8/19/pubmed PY - 2004/11/4/medline PY - 2004/8/19/entrez SP - 447 EP - 55 JF - Journal of bone and mineral metabolism JO - J Bone Miner Metab VL - 22 IS - 5 N2 - Evaluation of bone mineral content/bone mass density (BMC/BMD) is important to determine bone mass development among adolescents in health and disease. It is uncertain at which skeletal site BMC/BMD is best predicted by bone mass determinants. On the other hand, intrapersonal BMC/BMD data can be clustered into a composite index score to facilitate correlation and outcome prediction analysis. This study aimed to identify the skeletal site that was best predicted by bone mass determinants and to develop a composite index score based on multisite BMC/BMD values in healthy adolescent girls. Eleven BMD/BMC variables per subject were evaluated by using dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) in 236 healthy girls aged 12-15 years. Bone mass determinants, namely, weight, height, puberty, dietary calcium, physical activity, and bone turnover markers, were determined. Factor analysis was used to develop composite index scores that summarized characteristics of multisite BMC/BMD. Results showed that lumbar spinal BMD and BMC (by DXA) and tibial integral BMD (by pQCT) were the BMC/BMD sites better predicted by bone mass determinants (R2, 0.57-0.77) in multiple regression analysis. On the other hand, three composite index scores representing areal BMD, areal BMC, and vBMD were derived to summarize the original BMC/BMD values. The composite index scores had similar predicting power (R2, 0.419-0.749) compared to those of original BMC/BMD, indicating that the composite index scores were representative of the original variables. To conclude, lumbar spinal BMD and BMC and tibial integral BMD were the three BMC/BMD variables better predicted by bone mass determinants. This evaluation would help select appropriate skeletal sites as outcome measures for bone mass evaluation in future studies. Also, the development of composite index scores could help reduce the number of variables for correlation and outcome prediction analyses. SN - 0914-8779 UR - https://www.unboundmedicine.com/medline/citation/15316865/Bone_densitometry:_which_skeletal_sites_are_best_predicted_by_bone_mass_determinants L2 - https://dx.doi.org/10.1007/s00774-004-0506-2 DB - PRIME DP - Unbound Medicine ER -