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D2-dopamine receptor and alpha2-adrenoreceptor-mediated analgesic response of quercetin.
Indian J Exp Biol. 2003 Dec; 41(12):1400-4.IJ

Abstract

Quercetin, a bioflavonoid (100-300 mg/kg) produced dose dependent increase in tail-flick latency, the analgesic effect being sensitive to reversal by naloxone (1 mg/kg). Prior treatment with haloperidol (1 mg/kg), D1/D2 receptor antagonist haloperidol, sulpiride (50 mg/kg), a selective D2 receptor antagonist, yohimbine (5 mg/kg), a alpha2-adrenoreceptor antagonist but not by SCH 23390 a, selective D1 receptor antagonist blocked this response. Apomorphine (1 mg/kg) a mixed D1/D2 dopamine receptor agonist, and quinpirole (0.5 mg/kg), a selective D2 receptor agonist also produced antinociception, that was reversed by haloperidol (1 mg/kg), sulpiride (50 mg/kg), but not by yohimbine (5 mg/kg). The antinociceptive action of quercetin (200 mg/kg) was potentiated by D2 agonist quinpirole (0.2 mg/kg). Dopamine D1 receptor agonist SKF38393 (10 and 15 mg/kg) failed to alter the antinociceptive effect of quercetin (200 mg/kg). Quercetin (200 mg/kg) reversed reserpine (2 mg/kg-4 hr) induced hyperalgesia, which was reversed by sulpiride but not by yohimbine. Thus, a role of dopamine D2 and alpha2-adrenoreceptors is postulated in the antinociceptive action of quercetin.

Authors+Show Affiliations

Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160 014, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15320492

Citation

Naidu, Pattipati S., et al. "D2-dopamine Receptor and Alpha2-adrenoreceptor-mediated Analgesic Response of Quercetin." Indian Journal of Experimental Biology, vol. 41, no. 12, 2003, pp. 1400-4.
Naidu PS, Singh A, Kulkarni SK. D2-dopamine receptor and alpha2-adrenoreceptor-mediated analgesic response of quercetin. Indian J Exp Biol. 2003;41(12):1400-4.
Naidu, P. S., Singh, A., & Kulkarni, S. K. (2003). D2-dopamine receptor and alpha2-adrenoreceptor-mediated analgesic response of quercetin. Indian Journal of Experimental Biology, 41(12), 1400-4.
Naidu PS, Singh A, Kulkarni SK. D2-dopamine Receptor and Alpha2-adrenoreceptor-mediated Analgesic Response of Quercetin. Indian J Exp Biol. 2003;41(12):1400-4. PubMed PMID: 15320492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - D2-dopamine receptor and alpha2-adrenoreceptor-mediated analgesic response of quercetin. AU - Naidu,Pattipati S, AU - Singh,Amanpreet, AU - Kulkarni,Shrinivas K, PY - 2004/8/24/pubmed PY - 2004/9/24/medline PY - 2004/8/24/entrez SP - 1400 EP - 4 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 41 IS - 12 N2 - Quercetin, a bioflavonoid (100-300 mg/kg) produced dose dependent increase in tail-flick latency, the analgesic effect being sensitive to reversal by naloxone (1 mg/kg). Prior treatment with haloperidol (1 mg/kg), D1/D2 receptor antagonist haloperidol, sulpiride (50 mg/kg), a selective D2 receptor antagonist, yohimbine (5 mg/kg), a alpha2-adrenoreceptor antagonist but not by SCH 23390 a, selective D1 receptor antagonist blocked this response. Apomorphine (1 mg/kg) a mixed D1/D2 dopamine receptor agonist, and quinpirole (0.5 mg/kg), a selective D2 receptor agonist also produced antinociception, that was reversed by haloperidol (1 mg/kg), sulpiride (50 mg/kg), but not by yohimbine (5 mg/kg). The antinociceptive action of quercetin (200 mg/kg) was potentiated by D2 agonist quinpirole (0.2 mg/kg). Dopamine D1 receptor agonist SKF38393 (10 and 15 mg/kg) failed to alter the antinociceptive effect of quercetin (200 mg/kg). Quercetin (200 mg/kg) reversed reserpine (2 mg/kg-4 hr) induced hyperalgesia, which was reversed by sulpiride but not by yohimbine. Thus, a role of dopamine D2 and alpha2-adrenoreceptors is postulated in the antinociceptive action of quercetin. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/15320492/D2_dopamine_receptor_and_alpha2_adrenoreceptor_mediated_analgesic_response_of_quercetin_ DB - PRIME DP - Unbound Medicine ER -