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[Relationship between plasminogen activator inhibitor-1 gene 4G/5G polymorphism and type 2 diabetic nephropathy in Chinese Han patients in Guangdong Province].
Di Yi Jun Yi Da Xue Xue Bao. 2004 Aug; 24(8):904-7.DY

Abstract

OBJECTIVE

To understand the association between plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G polymorphism and type 2 diabetic nephropathy (DN) in Chinese Han patients in Guangdong Province.

METHODS

PAI-1 gene 4G/5G polymorphism was analyzed in 26 normal individuals, 77 patients with type 2 diabetic nephropathy and 70 type 2 diabetic patients without nephropathy (DNN) by polymerase chain reaction-restriction fragment length polymorphism.

RESULTS

The 4G/4G genotype frequencies of PAI-1 gene were higher in DN than in DNN patients (0.390 vs 0.171, chi(2)=13.008, P<0.01), with the odds ratio (OR) of 1.447 (95% confidence interval: 0.533-3.934, P<0.05) in comparison with 5G/5G genotypes between the 2 patient groups. The 4G allele frequencies of PAI-1 gene were similar in DN and DNN groups (0.57 vs 0.51, chi(2)=1.22, P>0.05).

CONCLUSION

The PAI-1 4G/4G genotype is associated with increased risk for type 2 DN the Chinese Han population in Guangdong Province, and type 2 diabetic patients with 4G/4G PAI-1 genotype are more likely to develop DN than those with 5G/5G PAI-1 genotype.

Authors+Show Affiliations

Liu SQ
Department of Endocrinology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Xue YM
No affiliation info available
Yang GC
No affiliation info available
He FY
No affiliation info available
Zhao XS
No affiliation info available

MeSH

AgedChinaDiabetes Mellitus, Type 2Diabetic NephropathiesFemaleGene FrequencyGenotypeHumansMaleMiddle AgedPlasminogen Activator Inhibitor 1Polymorphism, Genetic

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15321757

Citation

Liu, Shi-qun, et al. "[Relationship Between Plasminogen Activator Inhibitor-1 Gene 4G/5G Polymorphism and Type 2 Diabetic Nephropathy in Chinese Han Patients in Guangdong Province]." Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA, vol. 24, no. 8, 2004, pp. 904-7.
Liu SQ, Xue YM, Yang GC, et al. [Relationship between plasminogen activator inhibitor-1 gene 4G/5G polymorphism and type 2 diabetic nephropathy in Chinese Han patients in Guangdong Province]. Di Yi Jun Yi Da Xue Xue Bao. 2004;24(8):904-7.
Liu, S. Q., Xue, Y. M., Yang, G. C., He, F. Y., & Zhao, X. S. (2004). [Relationship between plasminogen activator inhibitor-1 gene 4G/5G polymorphism and type 2 diabetic nephropathy in Chinese Han patients in Guangdong Province]. Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA, 24(8), 904-7.
Liu SQ, et al. [Relationship Between Plasminogen Activator Inhibitor-1 Gene 4G/5G Polymorphism and Type 2 Diabetic Nephropathy in Chinese Han Patients in Guangdong Province]. Di Yi Jun Yi Da Xue Xue Bao. 2004;24(8):904-7. PubMed PMID: 15321757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Relationship between plasminogen activator inhibitor-1 gene 4G/5G polymorphism and type 2 diabetic nephropathy in Chinese Han patients in Guangdong Province]. AU - Liu,Shi-qun, AU - Xue,Yao-ming, AU - Yang,Guang-cai, AU - He,Fei-ying, AU - Zhao,Xiao-shan, PY - 2004/8/24/pubmed PY - 2007/5/2/medline PY - 2004/8/24/entrez SP - 904 EP - 7 JF - Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA JO - Di Yi Jun Yi Da Xue Xue Bao VL - 24 IS - 8 N2 - OBJECTIVE: To understand the association between plasminogen activator inhibitor-1 (PAI-1) gene 4G/5G polymorphism and type 2 diabetic nephropathy (DN) in Chinese Han patients in Guangdong Province. METHODS: PAI-1 gene 4G/5G polymorphism was analyzed in 26 normal individuals, 77 patients with type 2 diabetic nephropathy and 70 type 2 diabetic patients without nephropathy (DNN) by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: The 4G/4G genotype frequencies of PAI-1 gene were higher in DN than in DNN patients (0.390 vs 0.171, chi(2)=13.008, P<0.01), with the odds ratio (OR) of 1.447 (95% confidence interval: 0.533-3.934, P<0.05) in comparison with 5G/5G genotypes between the 2 patient groups. The 4G allele frequencies of PAI-1 gene were similar in DN and DNN groups (0.57 vs 0.51, chi(2)=1.22, P>0.05). CONCLUSION: The PAI-1 4G/4G genotype is associated with increased risk for type 2 DN the Chinese Han population in Guangdong Province, and type 2 diabetic patients with 4G/4G PAI-1 genotype are more likely to develop DN than those with 5G/5G PAI-1 genotype. SN - 1000-2588 UR - https://www.unboundmedicine.com/medline/citation/15321757/[Relationship_between_plasminogen_activator_inhibitor_1_gene_4G/5G_polymorphism_and_type_2_diabetic_nephropathy_in_Chinese_Han_patients_in_Guangdong_Province]_ DB - PRIME DP - Unbound Medicine ER -