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Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes.
Am J Clin Nutr 2004; 80(3):668-73AJ

Abstract

BACKGROUND

An important therapeutic goal for patients with type 2 diabetes is weight loss, which improves metabolic abnormalities. Ad libitum low-fat diets cause weight loss in nondiabetic populations. Compared with diets higher in monounsaturated fat, however, eucaloric low-fat diets may increase plasma triacylglycerol concentrations and worsen glycemic control in persons with type 2 diabetes.

OBJECTIVE

We investigated whether, in type 2 diabetes patients, an ad libitum low-fat diet would cause greater weight loss than would a high-monounsaturated fat diet and would do this without increasing plasma triacylglycerol concentrations or worsening glycemic control.

DESIGN

Eleven patients with type 2 diabetes were randomly assigned to receive an ad libitum low-fat, high-carbohydrate diet or a high-monounsaturated fat diet, each for 6 wk. The diets offered contained 125% of the estimated energy requirement to allow self-selection of food quantity. The response variables were body weight; fasting plasma lipid, lipoprotein, glucose, glycated hemoglobin A(1c), and fructosamine concentrations; insulin sensitivity; and glucose disposal.

RESULTS

Body weight decreased significantly (1.53 kg; P < 0.001) only with the low-fat diet. Plasma total, LDL-, and HDL-cholesterol concentrations tended to decrease during both diets. There were no interaction effects between diet and the lipid profile response over time. Plasma triacylglycerol concentrations, glycemic control, and insulin sensitivity did not differ significantly between the 2 diets.

CONCLUSION

Contrary to expectations, the ad libitum, low-fat, high-fiber diet promoted weight loss in patients with type 2 diabetes without causing unfavorable alterations in plasma lipids or glycemic control.

Authors+Show Affiliations

Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15321807

Citation

Gerhard, Glenn T., et al. "Effects of a Low-fat Diet Compared With Those of a High-monounsaturated Fat Diet On Body Weight, Plasma Lipids and Lipoproteins, and Glycemic Control in Type 2 Diabetes." The American Journal of Clinical Nutrition, vol. 80, no. 3, 2004, pp. 668-73.
Gerhard GT, Ahmann A, Meeuws K, et al. Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes. Am J Clin Nutr. 2004;80(3):668-73.
Gerhard, G. T., Ahmann, A., Meeuws, K., McMurry, M. P., Duell, P. B., & Connor, W. E. (2004). Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes. The American Journal of Clinical Nutrition, 80(3), pp. 668-73.
Gerhard GT, et al. Effects of a Low-fat Diet Compared With Those of a High-monounsaturated Fat Diet On Body Weight, Plasma Lipids and Lipoproteins, and Glycemic Control in Type 2 Diabetes. Am J Clin Nutr. 2004;80(3):668-73. PubMed PMID: 15321807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes. AU - Gerhard,Glenn T, AU - Ahmann,Andrew, AU - Meeuws,Kaatje, AU - McMurry,Martha P, AU - Duell,P Barton, AU - Connor,William E, PY - 2004/8/24/pubmed PY - 2004/9/24/medline PY - 2004/8/24/entrez SP - 668 EP - 73 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 3 N2 - BACKGROUND: An important therapeutic goal for patients with type 2 diabetes is weight loss, which improves metabolic abnormalities. Ad libitum low-fat diets cause weight loss in nondiabetic populations. Compared with diets higher in monounsaturated fat, however, eucaloric low-fat diets may increase plasma triacylglycerol concentrations and worsen glycemic control in persons with type 2 diabetes. OBJECTIVE: We investigated whether, in type 2 diabetes patients, an ad libitum low-fat diet would cause greater weight loss than would a high-monounsaturated fat diet and would do this without increasing plasma triacylglycerol concentrations or worsening glycemic control. DESIGN: Eleven patients with type 2 diabetes were randomly assigned to receive an ad libitum low-fat, high-carbohydrate diet or a high-monounsaturated fat diet, each for 6 wk. The diets offered contained 125% of the estimated energy requirement to allow self-selection of food quantity. The response variables were body weight; fasting plasma lipid, lipoprotein, glucose, glycated hemoglobin A(1c), and fructosamine concentrations; insulin sensitivity; and glucose disposal. RESULTS: Body weight decreased significantly (1.53 kg; P < 0.001) only with the low-fat diet. Plasma total, LDL-, and HDL-cholesterol concentrations tended to decrease during both diets. There were no interaction effects between diet and the lipid profile response over time. Plasma triacylglycerol concentrations, glycemic control, and insulin sensitivity did not differ significantly between the 2 diets. CONCLUSION: Contrary to expectations, the ad libitum, low-fat, high-fiber diet promoted weight loss in patients with type 2 diabetes without causing unfavorable alterations in plasma lipids or glycemic control. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15321807/Effects_of_a_low_fat_diet_compared_with_those_of_a_high_monounsaturated_fat_diet_on_body_weight_plasma_lipids_and_lipoproteins_and_glycemic_control_in_type_2_diabetes_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.3.668 DB - PRIME DP - Unbound Medicine ER -