Tags

Type your tag names separated by a space and hit enter

Prevention of cancers of the breast, endometrium and ovary.
Oncogene. 2004 Aug 23; 23(38):6379-91.O

Abstract

A central epidemiological feature of cancers of the breast, endometrium and ovary is the sharp slowing down in their rate of increase with age around the time of menopause. The incidence of these tumors by the age of 70 years would be between fourfold and eightfold increased if the rapid increase with age seen in young women continued into old age. These phenomena can be explained by the different effects of ovarian hormones on cell division rates in the relevant tissues. Models of these effects provide a plausible explanation of most of the known epidemiology of each of the cancers, including the increase in breast cancer risk from menopausal estrogen-progestin therapy. Some recent epidemiological findings in endometrial and ovarian cancer suggest new avenues for possible chemoprevention of these cancers.

Authors+Show Affiliations

USC/Norris Cancer Center, Los Angeles, CA, USA. mcpike@usc.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15322512

Citation

Pike, Malcolm C., et al. "Prevention of Cancers of the Breast, Endometrium and Ovary." Oncogene, vol. 23, no. 38, 2004, pp. 6379-91.
Pike MC, Pearce CL, Wu AH. Prevention of cancers of the breast, endometrium and ovary. Oncogene. 2004;23(38):6379-91.
Pike, M. C., Pearce, C. L., & Wu, A. H. (2004). Prevention of cancers of the breast, endometrium and ovary. Oncogene, 23(38), 6379-91.
Pike MC, Pearce CL, Wu AH. Prevention of Cancers of the Breast, Endometrium and Ovary. Oncogene. 2004 Aug 23;23(38):6379-91. PubMed PMID: 15322512.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of cancers of the breast, endometrium and ovary. AU - Pike,Malcolm C, AU - Pearce,Celeste Leigh, AU - Wu,Anna H, PY - 2004/8/24/pubmed PY - 2004/9/16/medline PY - 2004/8/24/entrez SP - 6379 EP - 91 JF - Oncogene JO - Oncogene VL - 23 IS - 38 N2 - A central epidemiological feature of cancers of the breast, endometrium and ovary is the sharp slowing down in their rate of increase with age around the time of menopause. The incidence of these tumors by the age of 70 years would be between fourfold and eightfold increased if the rapid increase with age seen in young women continued into old age. These phenomena can be explained by the different effects of ovarian hormones on cell division rates in the relevant tissues. Models of these effects provide a plausible explanation of most of the known epidemiology of each of the cancers, including the increase in breast cancer risk from menopausal estrogen-progestin therapy. Some recent epidemiological findings in endometrial and ovarian cancer suggest new avenues for possible chemoprevention of these cancers. SN - 0950-9232 UR - https://www.unboundmedicine.com/medline/citation/15322512/Prevention_of_cancers_of_the_breast_endometrium_and_ovary_ DB - PRIME DP - Unbound Medicine ER -