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Gastroduodenal lesions and Helicobacter pylori infection in hemodialysis patients.
Saudi Med J. 2004 Aug; 25(8):1010-4.SM

Abstract

OBJECTIVE

The purpose of this prospective study is to determine the prevalence of upper gastrointestinal (GI) abnormalities and Helicobacter pylori (H. pylori) infection among stable chronic hemodialysis (HD) patients.

METHODS

The study was carried out at King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia during the period January 1996 to June 1997. Fifty-four chronic HD patients underwent upper GI endoscopy. Endoscopic changes were described and multiple antral gastric biopsies were taken for histological examination and detection of H. pylori infection. Gastric biopsy findings were compared to findings in 60 consecutive patients with normal renal function undergoing endoscopy for assessment of dyspepsia.

RESULTS

Fifty-four stable chronic HD patients (32 men, mean age 42.4 +/- 18 years) underwent upper GI endoscopy and multiple antral gastric biopsies for histological examination and H. pylori detection. The endoscopic findings were abnormal in 49 (90.7%) patients. Chronic gastritis was seen in 20 (37%) patients, acute gastritis was seen in 13 (20.1%) patients, duodenal ulcer was seen in 6 (11.1%) patients, duodenitis with or without erosions was seen in 5 (9.3%) patients, gastroduodenitis was seen in 3 (5.56%) patients, and gastroesophageal reflux disease was seen in 2 (3.7%) patients. Histological examination of multiple antral gastric biopsies documented chronic active gastritis in 28 (51.9%) patients. Helicobacter pylori were present in 34(63%) patients. Helicobacter pylori were detected in the majority (85.7%) of patients with the histological diagnosis of chronic active gastritis. Patients harboring H. pylori were significantly older than negative patients (52 +/- 16.1 versus 33.9 +/- 17.3 years, p<0.018). In a group of 60 patients with normal renal function undergoing endoscopy for assessment of dyspeptic symptoms during the same period, chronic active gastritis was found in 40 (66.7%) patients and H. pylori was detected in 38 (63.3%) patients.

CONCLUSION

Upper GI abnormalities are common among HD patients even in the absence of symptoms. Biopsy proven chronic active gastritis is the most common histological diagnosis among these patients and is highly associated with H. pylori infection. Prevalence of H.pylori infection in HD patients is similar to those with normal renal function undergoing endoscopy for dyspepsia. Helicobacter pylori infected HD patients tend to be older than patients without H.pylori infection.

Authors+Show Affiliations

Department of Internal Medicine, King Fahd Hospital of the University, PO Box 40154, Al-Khobar 31952, Kingdom of Saudi Arabia. samir1375@hotmail.com

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15322589

Citation

Al-Mueilo, Samir H.. "Gastroduodenal Lesions and Helicobacter Pylori Infection in Hemodialysis Patients." Saudi Medical Journal, vol. 25, no. 8, 2004, pp. 1010-4.
Al-Mueilo SH. Gastroduodenal lesions and Helicobacter pylori infection in hemodialysis patients. Saudi Med J. 2004;25(8):1010-4.
Al-Mueilo, S. H. (2004). Gastroduodenal lesions and Helicobacter pylori infection in hemodialysis patients. Saudi Medical Journal, 25(8), 1010-4.
Al-Mueilo SH. Gastroduodenal Lesions and Helicobacter Pylori Infection in Hemodialysis Patients. Saudi Med J. 2004;25(8):1010-4. PubMed PMID: 15322589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastroduodenal lesions and Helicobacter pylori infection in hemodialysis patients. A1 - Al-Mueilo,Samir H, PY - 2004/8/24/pubmed PY - 2004/10/27/medline PY - 2004/8/24/entrez SP - 1010 EP - 4 JF - Saudi medical journal JO - Saudi Med J VL - 25 IS - 8 N2 - OBJECTIVE: The purpose of this prospective study is to determine the prevalence of upper gastrointestinal (GI) abnormalities and Helicobacter pylori (H. pylori) infection among stable chronic hemodialysis (HD) patients. METHODS: The study was carried out at King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia during the period January 1996 to June 1997. Fifty-four chronic HD patients underwent upper GI endoscopy. Endoscopic changes were described and multiple antral gastric biopsies were taken for histological examination and detection of H. pylori infection. Gastric biopsy findings were compared to findings in 60 consecutive patients with normal renal function undergoing endoscopy for assessment of dyspepsia. RESULTS: Fifty-four stable chronic HD patients (32 men, mean age 42.4 +/- 18 years) underwent upper GI endoscopy and multiple antral gastric biopsies for histological examination and H. pylori detection. The endoscopic findings were abnormal in 49 (90.7%) patients. Chronic gastritis was seen in 20 (37%) patients, acute gastritis was seen in 13 (20.1%) patients, duodenal ulcer was seen in 6 (11.1%) patients, duodenitis with or without erosions was seen in 5 (9.3%) patients, gastroduodenitis was seen in 3 (5.56%) patients, and gastroesophageal reflux disease was seen in 2 (3.7%) patients. Histological examination of multiple antral gastric biopsies documented chronic active gastritis in 28 (51.9%) patients. Helicobacter pylori were present in 34(63%) patients. Helicobacter pylori were detected in the majority (85.7%) of patients with the histological diagnosis of chronic active gastritis. Patients harboring H. pylori were significantly older than negative patients (52 +/- 16.1 versus 33.9 +/- 17.3 years, p<0.018). In a group of 60 patients with normal renal function undergoing endoscopy for assessment of dyspeptic symptoms during the same period, chronic active gastritis was found in 40 (66.7%) patients and H. pylori was detected in 38 (63.3%) patients. CONCLUSION: Upper GI abnormalities are common among HD patients even in the absence of symptoms. Biopsy proven chronic active gastritis is the most common histological diagnosis among these patients and is highly associated with H. pylori infection. Prevalence of H.pylori infection in HD patients is similar to those with normal renal function undergoing endoscopy for dyspepsia. Helicobacter pylori infected HD patients tend to be older than patients without H.pylori infection. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/15322589/Gastroduodenal_lesions_and_Helicobacter_pylori_infection_in_hemodialysis_patients_ DB - PRIME DP - Unbound Medicine ER -