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Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline.
Psychopharmacology (Berl). 2005 Mar; 178(2-3):317-27.P

Abstract

RATIONALE

The results of recent in vitro studies have underscored the important role that activation of CB(1) receptors has on GABAergic activity in brain areas associated with memory.

OBJECTIVES

The primary purpose of this study was to test the hypothesis that the memory disruptive effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in vivo are mediated through GABAergic systems. Conversely, we also evaluated whether blocking CB(1) receptor signaling would alter memory deficits elicited by GABA agonists.

METHODS

The GABA(A) antagonist bicuculline and GABA(B) antagonist CGP 36742 were evaluated for their ability to ameliorate Delta(9)-THC-induced deficits in a mouse working memory Morris water maze task. Mice were also assessed in a T-maze task, as well as non-cognitive behavioral assays. Additionally, the effects of GABA(A) and GABA(B) agonists were assessed in either CB(1) (-/-) mice or wild type mice treated with the CB(1) antagonist SR 141716.

RESULTS

Memory deficits resulting from 10 mg/kg Delta(9)-THC in the Morris water maze were completely reversed by bicuculline, though unaffected by CGP 36742. Bicuculline also blocked the disruptive effects of Delta(9)-THC in the T-maze, but failed to alter non-mnemonic effects of Delta(9)-THC. Although CB(1) (-/-) mice exhibited supersensitivity to muscimol-induced water maze deficits compared with wild type control mice, muscimol elicited virtually identical effects in SR 141716-treated and vehicle-treated wild type mice.

CONCLUSIONS

This is the first demonstration of which we are aware showing that GABA(A) receptors may play a necessary role in Delta(9)-THC-induced memory impairment in whole animals.

Authors+Show Affiliations

Department of Pharmacology, VCU, PO Box 980613, Richmond, VA 23298, USA. savarvel@vcu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15322725

Citation

Varvel, S A., et al. "Delta(9)-THC-induced Cognitive Deficits in Mice Are Reversed By the GABA(A) Antagonist Bicuculline." Psychopharmacology, vol. 178, no. 2-3, 2005, pp. 317-27.
Varvel SA, Anum E, Niyuhire F, et al. Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline. Psychopharmacology (Berl). 2005;178(2-3):317-27.
Varvel, S. A., Anum, E., Niyuhire, F., Wise, L. E., & Lichtman, A. H. (2005). Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline. Psychopharmacology, 178(2-3), 317-27.
Varvel SA, et al. Delta(9)-THC-induced Cognitive Deficits in Mice Are Reversed By the GABA(A) Antagonist Bicuculline. Psychopharmacology (Berl). 2005;178(2-3):317-27. PubMed PMID: 15322725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta(9)-THC-induced cognitive deficits in mice are reversed by the GABA(A) antagonist bicuculline. AU - Varvel,S A, AU - Anum,E, AU - Niyuhire,F, AU - Wise,L E, AU - Lichtman,A H, Y1 - 2004/08/20/ PY - 2004/05/26/received PY - 2004/07/07/accepted PY - 2004/8/24/pubmed PY - 2005/9/13/medline PY - 2004/8/24/entrez SP - 317 EP - 27 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 178 IS - 2-3 N2 - RATIONALE: The results of recent in vitro studies have underscored the important role that activation of CB(1) receptors has on GABAergic activity in brain areas associated with memory. OBJECTIVES: The primary purpose of this study was to test the hypothesis that the memory disruptive effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in vivo are mediated through GABAergic systems. Conversely, we also evaluated whether blocking CB(1) receptor signaling would alter memory deficits elicited by GABA agonists. METHODS: The GABA(A) antagonist bicuculline and GABA(B) antagonist CGP 36742 were evaluated for their ability to ameliorate Delta(9)-THC-induced deficits in a mouse working memory Morris water maze task. Mice were also assessed in a T-maze task, as well as non-cognitive behavioral assays. Additionally, the effects of GABA(A) and GABA(B) agonists were assessed in either CB(1) (-/-) mice or wild type mice treated with the CB(1) antagonist SR 141716. RESULTS: Memory deficits resulting from 10 mg/kg Delta(9)-THC in the Morris water maze were completely reversed by bicuculline, though unaffected by CGP 36742. Bicuculline also blocked the disruptive effects of Delta(9)-THC in the T-maze, but failed to alter non-mnemonic effects of Delta(9)-THC. Although CB(1) (-/-) mice exhibited supersensitivity to muscimol-induced water maze deficits compared with wild type control mice, muscimol elicited virtually identical effects in SR 141716-treated and vehicle-treated wild type mice. CONCLUSIONS: This is the first demonstration of which we are aware showing that GABA(A) receptors may play a necessary role in Delta(9)-THC-induced memory impairment in whole animals. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/15322725/Delta_9__THC_induced_cognitive_deficits_in_mice_are_reversed_by_the_GABA_A__antagonist_bicuculline_ L2 - https://dx.doi.org/10.1007/s00213-004-1988-2 DB - PRIME DP - Unbound Medicine ER -