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Papillomas and atypical papillomas in breast core needle biopsy specimens: risk of carcinoma in subsequent excision.
Am J Clin Pathol. 2004 Aug; 122(2):217-21.AJ

Abstract

We sought to define the risk associated with papillomas and atypical papillomas in breast core needle biopsy specimens from a series of approximately 8,500 biopsies performed during 8 years. From a total of 62 papillary lesions (including papillomas and atypical papillomas), 40 (65%) had histologic follow-up. Overall, 15 (38%) of 40 patients had ductal carcinoma in situ (12 cases) or invasive carcinoma at excision (3 cases). Eight cases diagnosed as papilloma had benign follow-up. Slides were available for review in 38 cases and reclassified into benign papilloma with florid hyperplasia and no or minimal atypia (18 cases), papilloma with separate foci of atypical ductal hyperplasia (7 cases), and severely atypical papillomas "suspicious" for papillary carcinoma (13 cases). Carcinoma was identified in 0 (0%), 2 (29%), and 12 (92%) cases, respectively. We conclude that while atypical papillary lesions and papillomas with associated atypical ductal hyperplasia in breast core needle biopsy specimens are associated with a risk of carcinoma, lesions diagnosed as papilloma or papilloma with no or minimal atypia are benign and do not need to be excised.

Authors+Show Affiliations

Department of Pathology, Baptist Hospital of Miami, FL 33176, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15323138

Citation

Renshaw, Andrew A., et al. "Papillomas and Atypical Papillomas in Breast Core Needle Biopsy Specimens: Risk of Carcinoma in Subsequent Excision." American Journal of Clinical Pathology, vol. 122, no. 2, 2004, pp. 217-21.
Renshaw AA, Derhagopian RP, Tizol-Blanco DM, et al. Papillomas and atypical papillomas in breast core needle biopsy specimens: risk of carcinoma in subsequent excision. Am J Clin Pathol. 2004;122(2):217-21.
Renshaw, A. A., Derhagopian, R. P., Tizol-Blanco, D. M., & Gould, E. W. (2004). Papillomas and atypical papillomas in breast core needle biopsy specimens: risk of carcinoma in subsequent excision. American Journal of Clinical Pathology, 122(2), 217-21.
Renshaw AA, et al. Papillomas and Atypical Papillomas in Breast Core Needle Biopsy Specimens: Risk of Carcinoma in Subsequent Excision. Am J Clin Pathol. 2004;122(2):217-21. PubMed PMID: 15323138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Papillomas and atypical papillomas in breast core needle biopsy specimens: risk of carcinoma in subsequent excision. AU - Renshaw,Andrew A, AU - Derhagopian,Robert P, AU - Tizol-Blanco,Dolores M, AU - Gould,Edwin W, PY - 2004/8/25/pubmed PY - 2004/9/24/medline PY - 2004/8/25/entrez SP - 217 EP - 21 JF - American journal of clinical pathology JO - Am J Clin Pathol VL - 122 IS - 2 N2 - We sought to define the risk associated with papillomas and atypical papillomas in breast core needle biopsy specimens from a series of approximately 8,500 biopsies performed during 8 years. From a total of 62 papillary lesions (including papillomas and atypical papillomas), 40 (65%) had histologic follow-up. Overall, 15 (38%) of 40 patients had ductal carcinoma in situ (12 cases) or invasive carcinoma at excision (3 cases). Eight cases diagnosed as papilloma had benign follow-up. Slides were available for review in 38 cases and reclassified into benign papilloma with florid hyperplasia and no or minimal atypia (18 cases), papilloma with separate foci of atypical ductal hyperplasia (7 cases), and severely atypical papillomas "suspicious" for papillary carcinoma (13 cases). Carcinoma was identified in 0 (0%), 2 (29%), and 12 (92%) cases, respectively. We conclude that while atypical papillary lesions and papillomas with associated atypical ductal hyperplasia in breast core needle biopsy specimens are associated with a risk of carcinoma, lesions diagnosed as papilloma or papilloma with no or minimal atypia are benign and do not need to be excised. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/15323138/Papillomas_and_atypical_papillomas_in_breast_core_needle_biopsy_specimens:_risk_of_carcinoma_in_subsequent_excision_ L2 - https://academic.oup.com/ajcp/article-lookup/doi/10.1309/K1BN-JXET-EY3H-06UL DB - PRIME DP - Unbound Medicine ER -