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Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea.
Fertil Steril. 1978 Dec; 30(6):654-60.FS

Abstract

The effects of epimestrol (5 mg every 6 hours for 5 days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause. The results in the first 18 patients indicate that epimestrol treatment induces a significant increase in LH and Prl levels after 24 hours, while the FSH increase becomes significant only after 4 days of therapy. Twelve hours after discontinuation of treatment, all three hormone levels decreased significantly to values similar to the basal levels, while the pituitary response to LH-RH indicated a much more marked LH secretion than before treatment. A second test, performed 36 hours after the last drug administration, again showed a significantly higher LH response than that found under basal conditions. No significant variations were observed in the FSH response to LH-RH, nor in the Prl response to TRH. These data suggest that epimestrol interferes at the level of the centers responsible for Prl and gonadotropin secretion in the manner of a weak estrogen.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

153243

Citation

Genazzani, A R., et al. "Effect of Epimestrol On Gonadotropin and Prolactin Plasma Levels and Response to Luteinizing Hormone-releasing Hormone/thyrotropin-releasing Hormone in Secondary Amenorrhea and Oligomenorrhea." Fertility and Sterility, vol. 30, no. 6, 1978, pp. 654-60.
Genazzani AR, Facchinetti F, de Leo V, et al. Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. Fertil Steril. 1978;30(6):654-60.
Genazzani, A. R., Facchinetti, F., de Leo, V., Picciolini, E., Franchi, F., Parrini, D., & Kicovic, P. M. (1978). Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. Fertility and Sterility, 30(6), 654-60.
Genazzani AR, et al. Effect of Epimestrol On Gonadotropin and Prolactin Plasma Levels and Response to Luteinizing Hormone-releasing Hormone/thyrotropin-releasing Hormone in Secondary Amenorrhea and Oligomenorrhea. Fertil Steril. 1978;30(6):654-60. PubMed PMID: 153243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of epimestrol on gonadotropin and prolactin plasma levels and response to luteinizing hormone-releasing hormone/thyrotropin-releasing hormone in secondary amenorrhea and oligomenorrhea. AU - Genazzani,A R, AU - Facchinetti,F, AU - de Leo,V, AU - Picciolini,E, AU - Franchi,F, AU - Parrini,D, AU - Kicovic,P M, PY - 1978/12/1/pubmed PY - 1978/12/1/medline PY - 1978/12/1/entrez SP - 654 EP - 60 JF - Fertility and sterility JO - Fertil Steril VL - 30 IS - 6 N2 - The effects of epimestrol (5 mg every 6 hours for 5 days) on basal levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (Prl), estradiol, progesterone, and dehydroepiandrosterone sulfate, and on the response to LH-releasing hormone (LH-RH) and thyrotropin-releasing hormone (TRH) stimulation, were studied in 18 cases of secondary amenorrhea and oligomenorrhea of hypothalamic-pituitary origin, in three cases of anorexia nervosa, in two cases of long-lasting progestin-induced amenorrhea, and in one case of precocious menopause. The results in the first 18 patients indicate that epimestrol treatment induces a significant increase in LH and Prl levels after 24 hours, while the FSH increase becomes significant only after 4 days of therapy. Twelve hours after discontinuation of treatment, all three hormone levels decreased significantly to values similar to the basal levels, while the pituitary response to LH-RH indicated a much more marked LH secretion than before treatment. A second test, performed 36 hours after the last drug administration, again showed a significantly higher LH response than that found under basal conditions. No significant variations were observed in the FSH response to LH-RH, nor in the Prl response to TRH. These data suggest that epimestrol interferes at the level of the centers responsible for Prl and gonadotropin secretion in the manner of a weak estrogen. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/153243/Effect_of_epimestrol_on_gonadotropin_and_prolactin_plasma_levels_and_response_to_luteinizing_hormone_releasing_hormone/thyrotropin_releasing_hormone_in_secondary_amenorrhea_and_oligomenorrhea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(16)43692-7 DB - PRIME DP - Unbound Medicine ER -