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Estrogen receptor-alpha gene polymorphisms in patients with periodontitis.
J Periodontal Res. 2004 Oct; 39(5):362-6.JP

Abstract

BACKGROUND

Recent studies have shown that estrogen receptor-alpha (ER-alpha) gene polymorphisms are associated with alterations in bone mineral density and osteoporosis. It is unclear whether ER-alpha gene polymorphisms are associated with alveolar bone loss in patients with periodontitis.

OBJECTIVE

The aim of this study was to investigate the relationship between ER-alpha gene polymorphisms and periodontitis.

METHODS

Ninety patients with aggressive periodontitis, 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. All these subjects belonged to the Han Chinese race. DNA was extracted from peripheral blood of each subject. The ER-alpha gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with PvuII and XbaI restriction endonucleases.

RESULTS

The detection frequency of XX genotype was significantly higher in the chronic periodontitis patients than in the healthy controls (11.8% vs. 4.4%, p < 0.05). The difference between the female chronic periodontitis patients and healthy controls (26.7% vs. 2.1%, p < 0.01) was statistically significant, but no difference was found between the male patients and controls (p > 0.05). The detection frequency of PvuII ER genotypes was not statistically different among the three groups (p > 0.05).

CONCLUSIONS

In female Han Chinese population, the XX genotype may be a risk indicator for chronic periodontitis.

Authors+Show Affiliations

Department of Periodontology, Peking University School of Stomatology, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15324358

Citation

Zhang, Li, et al. "Estrogen Receptor-alpha Gene Polymorphisms in Patients With Periodontitis." Journal of Periodontal Research, vol. 39, no. 5, 2004, pp. 362-6.
Zhang L, Meng H, Zhao H, et al. Estrogen receptor-alpha gene polymorphisms in patients with periodontitis. J Periodontal Res. 2004;39(5):362-6.
Zhang, L., Meng, H., Zhao, H., Li, Q., Xu, L., Chen, Z., Shi, D., & Feng, X. (2004). Estrogen receptor-alpha gene polymorphisms in patients with periodontitis. Journal of Periodontal Research, 39(5), 362-6.
Zhang L, et al. Estrogen Receptor-alpha Gene Polymorphisms in Patients With Periodontitis. J Periodontal Res. 2004;39(5):362-6. PubMed PMID: 15324358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor-alpha gene polymorphisms in patients with periodontitis. AU - Zhang,Li, AU - Meng,Huanxin, AU - Zhao,Hongshan, AU - Li,Qiyan, AU - Xu,Li, AU - Chen,Zhibin, AU - Shi,Dong, AU - Feng,Xianghui, PY - 2004/8/25/pubmed PY - 2004/10/27/medline PY - 2004/8/25/entrez SP - 362 EP - 6 JF - Journal of periodontal research JO - J Periodontal Res VL - 39 IS - 5 N2 - BACKGROUND: Recent studies have shown that estrogen receptor-alpha (ER-alpha) gene polymorphisms are associated with alterations in bone mineral density and osteoporosis. It is unclear whether ER-alpha gene polymorphisms are associated with alveolar bone loss in patients with periodontitis. OBJECTIVE: The aim of this study was to investigate the relationship between ER-alpha gene polymorphisms and periodontitis. METHODS: Ninety patients with aggressive periodontitis, 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. All these subjects belonged to the Han Chinese race. DNA was extracted from peripheral blood of each subject. The ER-alpha gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with PvuII and XbaI restriction endonucleases. RESULTS: The detection frequency of XX genotype was significantly higher in the chronic periodontitis patients than in the healthy controls (11.8% vs. 4.4%, p < 0.05). The difference between the female chronic periodontitis patients and healthy controls (26.7% vs. 2.1%, p < 0.01) was statistically significant, but no difference was found between the male patients and controls (p > 0.05). The detection frequency of PvuII ER genotypes was not statistically different among the three groups (p > 0.05). CONCLUSIONS: In female Han Chinese population, the XX genotype may be a risk indicator for chronic periodontitis. SN - 0022-3484 UR - https://www.unboundmedicine.com/medline/citation/15324358/Estrogen_receptor_alpha_gene_polymorphisms_in_patients_with_periodontitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0022-3484&amp;date=2004&amp;volume=39&amp;issue=5&amp;spage=362 DB - PRIME DP - Unbound Medicine ER -