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Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome.
Best Pract Res Clin Gastroenterol. 2004 Aug; 18(4):747-71.BP

Abstract

Pathophysiology of irritable bowel syndrome (IBS) is based upon multiple factors that have been organised in a comprehensive model centred around the brain-gut axis. The brain-gut axis encompasses nerve pathways linking the enteric and the central nervous systems and contains a large proportion of afferent fibres. Functionally and anatomically, visceral nerves are divided in to two categories: the parasympathetic pathways distributing to the upper gut through the vagi and to the hindgut, through the pelvic and pudendal nerves, and the sympathetic pathways, arising form the spinal cord and distributing to the midgut via the paravertebral ganglia. Several abnormalities of gut sensori-motor function have been described in patients with IBS. Abnormal motility patterns have been described at the intestinal and colonic levels. Changes in colonic motility are mainly related to bowel disturbances linked to IBS but do not correlate with pain. More recently, visceral hypersensitivity has been recognised as a main characteristic of patients with IBS. It is defined by an exaggerated perception of luminal distension of various segments of the gut and related to peripheral changes in the processing of visceral sensations as well as modulation of perception by centrally acting factors including mood and stress. Viscero-visceral reflexes link the two edges of the brain-gut axis and may account for the origin of symptoms in some pathological conditions. Recent advances in the understanding of the role of myenteric plexus allowed recognition of several neurotransmitters involved at the level of both the afferent and efferent pathways. Targeting the receptors of these neurotransmitters is a promising way for development of new treatments for IBS.

Authors+Show Affiliations

Department of Internal Medicine and Digestive Pathology, CHU de Brabois, F-54511 Vandoeuvre-les-Nancy, France. m.delvaux@chu-nancy.fr

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15324712

Citation

Delvaux, Michel. "Alterations of Sensori-motor Functions of the Digestive Tract in the Pathophysiology of Irritable Bowel Syndrome." Best Practice & Research. Clinical Gastroenterology, vol. 18, no. 4, 2004, pp. 747-71.
Delvaux M. Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome. Best Pract Res Clin Gastroenterol. 2004;18(4):747-71.
Delvaux, M. (2004). Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome. Best Practice & Research. Clinical Gastroenterology, 18(4), 747-71.
Delvaux M. Alterations of Sensori-motor Functions of the Digestive Tract in the Pathophysiology of Irritable Bowel Syndrome. Best Pract Res Clin Gastroenterol. 2004;18(4):747-71. PubMed PMID: 15324712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome. A1 - Delvaux,Michel, PY - 2004/8/25/pubmed PY - 2004/12/17/medline PY - 2004/8/25/entrez SP - 747 EP - 71 JF - Best practice & research. Clinical gastroenterology JO - Best Pract Res Clin Gastroenterol VL - 18 IS - 4 N2 - Pathophysiology of irritable bowel syndrome (IBS) is based upon multiple factors that have been organised in a comprehensive model centred around the brain-gut axis. The brain-gut axis encompasses nerve pathways linking the enteric and the central nervous systems and contains a large proportion of afferent fibres. Functionally and anatomically, visceral nerves are divided in to two categories: the parasympathetic pathways distributing to the upper gut through the vagi and to the hindgut, through the pelvic and pudendal nerves, and the sympathetic pathways, arising form the spinal cord and distributing to the midgut via the paravertebral ganglia. Several abnormalities of gut sensori-motor function have been described in patients with IBS. Abnormal motility patterns have been described at the intestinal and colonic levels. Changes in colonic motility are mainly related to bowel disturbances linked to IBS but do not correlate with pain. More recently, visceral hypersensitivity has been recognised as a main characteristic of patients with IBS. It is defined by an exaggerated perception of luminal distension of various segments of the gut and related to peripheral changes in the processing of visceral sensations as well as modulation of perception by centrally acting factors including mood and stress. Viscero-visceral reflexes link the two edges of the brain-gut axis and may account for the origin of symptoms in some pathological conditions. Recent advances in the understanding of the role of myenteric plexus allowed recognition of several neurotransmitters involved at the level of both the afferent and efferent pathways. Targeting the receptors of these neurotransmitters is a promising way for development of new treatments for IBS. SN - 1521-6918 UR - https://www.unboundmedicine.com/medline/citation/15324712/Alterations_of_sensori_motor_functions_of_the_digestive_tract_in_the_pathophysiology_of_irritable_bowel_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6918(04)00065-4 DB - PRIME DP - Unbound Medicine ER -