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Dietary alkyl thiol free radicals (RSS) can be as toxic as reactive oxygen species (ROS).
Med Hypotheses 2004; 63(4):667-70MH

Abstract

Harmful free-radicals, such as superoxide anion (a reactive oxygen species: ROS) are produced during aerobic respiration in all tissues because of only partial reduction of some oxygen molecules in mitochondria: this is due to one-electron reduction of each atom of oxygen, instead of four-electron reduction per molecule of oxygen to form water. Similarly, in liver, and many other tissues such as lung and brain, an electron transfer chain from NADPH to water occurs (with insertion of one oxygen atom into xenobiotic substrates) that uses cytochromes P450 (EC 1.14.14.1) as the electron acceptor. Here, futile recycling of electrons, in the absence of substrate produces the superoxide anion (*O2')--see above. Reactive oxygen species (ROS) and reactive sulfur species (RSS) may act in unison to damage biomolecules. For example, damage to biomolecules can occur by attack on phospholipid membranes, and also the targeting of DNA results in mutagenicity and associated carcinogenicity-related mutagenic damage. Free radical injury to low density lipoprotein (LDL) has been identified in the causation of atherosclerosis implicated in arterial disease, which can lead to heart attack and strokes.

Authors+Show Affiliations

Molecular Toxicology Group, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15325013

Citation

Wiseman, Alan. "Dietary Alkyl Thiol Free Radicals (RSS) Can Be as Toxic as Reactive Oxygen Species (ROS)." Medical Hypotheses, vol. 63, no. 4, 2004, pp. 667-70.
Wiseman A. Dietary alkyl thiol free radicals (RSS) can be as toxic as reactive oxygen species (ROS). Med Hypotheses. 2004;63(4):667-70.
Wiseman, A. (2004). Dietary alkyl thiol free radicals (RSS) can be as toxic as reactive oxygen species (ROS). Medical Hypotheses, 63(4), pp. 667-70.
Wiseman A. Dietary Alkyl Thiol Free Radicals (RSS) Can Be as Toxic as Reactive Oxygen Species (ROS). Med Hypotheses. 2004;63(4):667-70. PubMed PMID: 15325013.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary alkyl thiol free radicals (RSS) can be as toxic as reactive oxygen species (ROS). A1 - Wiseman,Alan, PY - 2004/03/18/received PY - 2004/03/18/accepted PY - 2004/8/25/pubmed PY - 2005/2/16/medline PY - 2004/8/25/entrez SP - 667 EP - 70 JF - Medical hypotheses JO - Med. Hypotheses VL - 63 IS - 4 N2 - Harmful free-radicals, such as superoxide anion (a reactive oxygen species: ROS) are produced during aerobic respiration in all tissues because of only partial reduction of some oxygen molecules in mitochondria: this is due to one-electron reduction of each atom of oxygen, instead of four-electron reduction per molecule of oxygen to form water. Similarly, in liver, and many other tissues such as lung and brain, an electron transfer chain from NADPH to water occurs (with insertion of one oxygen atom into xenobiotic substrates) that uses cytochromes P450 (EC 1.14.14.1) as the electron acceptor. Here, futile recycling of electrons, in the absence of substrate produces the superoxide anion (*O2')--see above. Reactive oxygen species (ROS) and reactive sulfur species (RSS) may act in unison to damage biomolecules. For example, damage to biomolecules can occur by attack on phospholipid membranes, and also the targeting of DNA results in mutagenicity and associated carcinogenicity-related mutagenic damage. Free radical injury to low density lipoprotein (LDL) has been identified in the causation of atherosclerosis implicated in arterial disease, which can lead to heart attack and strokes. SN - 0306-9877 UR - https://www.unboundmedicine.com/medline/citation/15325013/Dietary_alkyl_thiol_free_radicals__RSS__can_be_as_toxic_as_reactive_oxygen_species__ROS__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306987704002324 DB - PRIME DP - Unbound Medicine ER -