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Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2.
Int J Antimicrob Agents. 2004 Sep; 24(3):279-83.IJ

Abstract

A sulphated polysaccharide (SP2) was isolated from the brown alga Sargassum patens. SP2 inhibited the replication of herpes simplex virus type 2 (HSV-2) dose-dependently by 38.5-96.1% of the control level, after incubations with 0.78-12.5 microg/ml of the polysaccharide. SP2 exhibited extracellular virucidal activity only in high concentrations (>/=12.5 microg/ml) but significantly inhibited the virus attachment to its host cells by 45.1%, at concentration as low as 1 microg/ml. All the results from this study suggested that the antiviral mode of action of SP2 could be ascribed to the inhibition of virus adsorption, which is different from that of the current drug of choice acyclovir.

Authors+Show Affiliations

Zhu W
Department of Biology, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.
Chiu LC
No affiliation info available
Ooi VE
No affiliation info available
Chan PK
No affiliation info available
Ang PO
No affiliation info available

MeSH

AdsorptionAntiviral AgentsHerpesvirus 2, HumanPolysaccharidesSargassumViral Plaque AssayVirionVirus InactivationVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15325432

Clinical Trial Links

(CBDRA60) to Prevent or Reduce Symptoms of COVID-19 and Prevention of Post-Acute Sequelae of SARS-CoV-2 Infection PASC

Citation

Zhu, W, et al. "Antiviral Property and Mode of Action of a Sulphated Polysaccharide From Sargassum Patens Against Herpes Simplex Virus Type 2." International Journal of Antimicrobial Agents, vol. 24, no. 3, 2004, pp. 279-83.
Zhu W, Chiu LC, Ooi VE, et al. Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2. Int J Antimicrob Agents. 2004;24(3):279-83.
Zhu, W., Chiu, L. C., Ooi, V. E., Chan, P. K., & Ang, P. O. (2004). Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2. International Journal of Antimicrobial Agents, 24(3), 279-83.
Zhu W, et al. Antiviral Property and Mode of Action of a Sulphated Polysaccharide From Sargassum Patens Against Herpes Simplex Virus Type 2. Int J Antimicrob Agents. 2004;24(3):279-83. PubMed PMID: 15325432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2. AU - Zhu,W, AU - Chiu,L C M, AU - Ooi,V E C, AU - Chan,P K S, AU - Ang,P O,Jr PY - 2004/01/25/received PY - 2004/02/16/accepted PY - 2004/8/25/pubmed PY - 2005/2/19/medline PY - 2004/8/25/entrez SP - 279 EP - 83 JF - International journal of antimicrobial agents JO - Int J Antimicrob Agents VL - 24 IS - 3 N2 - A sulphated polysaccharide (SP2) was isolated from the brown alga Sargassum patens. SP2 inhibited the replication of herpes simplex virus type 2 (HSV-2) dose-dependently by 38.5-96.1% of the control level, after incubations with 0.78-12.5 microg/ml of the polysaccharide. SP2 exhibited extracellular virucidal activity only in high concentrations (>/=12.5 microg/ml) but significantly inhibited the virus attachment to its host cells by 45.1%, at concentration as low as 1 microg/ml. All the results from this study suggested that the antiviral mode of action of SP2 could be ascribed to the inhibition of virus adsorption, which is different from that of the current drug of choice acyclovir. SN - 0924-8579 UR - https://www.unboundmedicine.com/medline/citation/15325432/Antiviral_property_and_mode_of_action_of_a_sulphated_polysaccharide_from_Sargassum_patens_against_herpes_simplex_virus_type_2_ DB - PRIME DP - Unbound Medicine ER -