Tags

Type your tag names separated by a space and hit enter

Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin.
Arch Biochem Biophys. 2004 Oct 01; 430(1):70-6.AB

Abstract

Observational evidence is accumulating that the onset of age-related maculopathy, the leading cause of legal blindness in the Western World, could be delayed, or even averted, with antioxidant supplements. Lutein (L) and zeaxanthin (Z) are two hydroxy-carotenoids with antioxidant activity which accumulate at the macula, where they are collectively known as macular pigment (MP). It has been shown that MP is entirely of dietary origin, and that L and Z levels in serum, diet, and retina correlate. However, the nature of the relationships between L and Z in foodstuffs, blood, and macula is confounded by many variables including processes which influence digestion, absorption, and transport of the compounds in question, and accumulation and stabilization of the carotenoids in the tissues. If macular pigment is protective for age-related maculopathy, a clear understanding of the mechanisms whereby L and Z arrive at the target tissue (retina) from their source (foodstuff) is essential. In this paper, we review the literature germane to this growing area of interest.

Authors+Show Affiliations

Macular Pigment Laboratory, Waterford Institute of Technology, Cork Road, Waterford, Ireland. dualta@iol.ieNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15325913

Citation

Beatty, Stephen, et al. "Macular Pigment Optical Density and Its Relationship With Serum and Dietary Levels of Lutein and Zeaxanthin." Archives of Biochemistry and Biophysics, vol. 430, no. 1, 2004, pp. 70-6.
Beatty S, Nolan J, Kavanagh H, et al. Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin. Arch Biochem Biophys. 2004;430(1):70-6.
Beatty, S., Nolan, J., Kavanagh, H., & O'Donovan, O. (2004). Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin. Archives of Biochemistry and Biophysics, 430(1), 70-6.
Beatty S, et al. Macular Pigment Optical Density and Its Relationship With Serum and Dietary Levels of Lutein and Zeaxanthin. Arch Biochem Biophys. 2004 Oct 1;430(1):70-6. PubMed PMID: 15325913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin. AU - Beatty,Stephen, AU - Nolan,John, AU - Kavanagh,Heather, AU - O'Donovan,Orla, PY - 2003/12/14/received PY - 2004/02/22/revised PY - 2004/8/25/pubmed PY - 2004/9/24/medline PY - 2004/8/25/entrez SP - 70 EP - 6 JF - Archives of biochemistry and biophysics JO - Arch. Biochem. Biophys. VL - 430 IS - 1 N2 - Observational evidence is accumulating that the onset of age-related maculopathy, the leading cause of legal blindness in the Western World, could be delayed, or even averted, with antioxidant supplements. Lutein (L) and zeaxanthin (Z) are two hydroxy-carotenoids with antioxidant activity which accumulate at the macula, where they are collectively known as macular pigment (MP). It has been shown that MP is entirely of dietary origin, and that L and Z levels in serum, diet, and retina correlate. However, the nature of the relationships between L and Z in foodstuffs, blood, and macula is confounded by many variables including processes which influence digestion, absorption, and transport of the compounds in question, and accumulation and stabilization of the carotenoids in the tissues. If macular pigment is protective for age-related maculopathy, a clear understanding of the mechanisms whereby L and Z arrive at the target tissue (retina) from their source (foodstuff) is essential. In this paper, we review the literature germane to this growing area of interest. SN - 0003-9861 UR - https://www.unboundmedicine.com/medline/citation/15325913/Macular_pigment_optical_density_and_its_relationship_with_serum_and_dietary_levels_of_lutein_and_zeaxanthin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003986104001481 DB - PRIME DP - Unbound Medicine ER -