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Role of endocannabinoid system in mental diseases.

Abstract

In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid receptor activation. Cannabis has been historically used to relieve some of the symptoms associated with central nervous system disorders. Nowadays, there are anecdotal evidences for the use of cannabis in many patients suffering from multiple sclerosis or chronic pain. Following the historical reports of the use of cannabis for medicinal purposes, recent research has highlighted the potential of cannabinoids to treat a wide variety of clinical disorders. Some of these disorders that are being investigated are pain, motor dysfunctions or psychiatric illness. On the other hand, cannabis abuse has been related to several psychiatric disorders such as dependence, anxiety, depression, cognitive impairment, and psychosis. Considering that cannabis or cannabinoid pharmaceutical preparations may no longer be exclusively recreational drugs but may also present potential therapeutic uses, it has become of great interest to analyze the neurobiological and behavioral consequences of their administration. This review attempts to link current understanding of the basic neurobiology of the endocannabinoid system to novel opportunities for therapeutic intervention and its effects on the central nervous system.

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  • Authors+Show Affiliations

    ,

    Servicio de Psiquiatría y Unidad de Investigación, Hospital 12 de Octubre, Edificio Materno-Infantil, Planta 6a, 613-A, Avenida de Córdoba s/n. 28041 Madrid, Spain. jorgemr@h12o.es

    , ,

    Source

    Neurotoxicity research 6:3 2004 pg 213-24

    MeSH

    Analgesia
    Animals
    Brain
    Cannabinoid Receptor Modulators
    Cognition Disorders
    Dronabinol
    Endocannabinoids
    Feeding Behavior
    History, 20th Century
    History, 21st Century
    Humans
    Mental Disorders
    Movement Disorders
    Receptor, Cannabinoid, CB1

    Pub Type(s)

    Historical Article
    Journal Article
    Review

    Language

    eng

    PubMed ID

    15325960

    Citation

    Manzanares, Jorge, et al. "Role of Endocannabinoid System in Mental Diseases." Neurotoxicity Research, vol. 6, no. 3, 2004, pp. 213-24.
    Manzanares J, Urigüen L, Rubio G, et al. Role of endocannabinoid system in mental diseases. Neurotox Res. 2004;6(3):213-24.
    Manzanares, J., Urigüen, L., Rubio, G., & Palomo, T. (2004). Role of endocannabinoid system in mental diseases. Neurotoxicity Research, 6(3), pp. 213-24.
    Manzanares J, et al. Role of Endocannabinoid System in Mental Diseases. Neurotox Res. 2004;6(3):213-24. PubMed PMID: 15325960.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of endocannabinoid system in mental diseases. AU - Manzanares,Jorge, AU - Urigüen,Leyre, AU - Rubio,Gabriel, AU - Palomo,Tomás, PY - 2004/8/25/pubmed PY - 2005/2/3/medline PY - 2004/8/25/entrez SP - 213 EP - 24 JF - Neurotoxicity research JO - Neurotox Res VL - 6 IS - 3 N2 - In the last decade, a large number of studies using Delta9-tetrahydrocannabinol (THC), the main active principle derivative of the marijuana plant, or cannabinoid synthetic derivatives have substantially contributed to advance the understanding of the pharmacology and neurobiological mechanisms produced by cannabinoid receptor activation. Cannabis has been historically used to relieve some of the symptoms associated with central nervous system disorders. Nowadays, there are anecdotal evidences for the use of cannabis in many patients suffering from multiple sclerosis or chronic pain. Following the historical reports of the use of cannabis for medicinal purposes, recent research has highlighted the potential of cannabinoids to treat a wide variety of clinical disorders. Some of these disorders that are being investigated are pain, motor dysfunctions or psychiatric illness. On the other hand, cannabis abuse has been related to several psychiatric disorders such as dependence, anxiety, depression, cognitive impairment, and psychosis. Considering that cannabis or cannabinoid pharmaceutical preparations may no longer be exclusively recreational drugs but may also present potential therapeutic uses, it has become of great interest to analyze the neurobiological and behavioral consequences of their administration. This review attempts to link current understanding of the basic neurobiology of the endocannabinoid system to novel opportunities for therapeutic intervention and its effects on the central nervous system. SN - 1029-8428 UR - https://www.unboundmedicine.com/medline/citation/15325960/Role_of_endocannabinoid_system_in_mental_diseases_ L2 - https://medlineplus.gov/mentaldisorders.html DB - PRIME DP - Unbound Medicine ER -