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A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease.
J Int Neuropsychol Soc. 2004 Sep; 10(5):689-97.JI

Abstract

Little is known about possible differences in the memory deficits that occur in Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We compared 24 autopsy-confirmed DLB and 24 age-, education-, and MMSE-matched autopsy-confirmed AD patients on the California Verbal Learning Test (CVLT) and the Wechsler Memory Scale-Revised Logical Memory subtest. The DLB and AD groups were similarly impaired on CVLT Total Learning (Trials 15) and Long Delayed Free Recall, but the DLB group demonstrated relative improvement in Savings scores and on recognition testing compared to the AD group. Likewise, the patient groups were equally impaired on Logical Memory immediate and delayed recall, but the DLB group's Saving scores were significantly better than those of the AD patients. These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients.

Authors+Show Affiliations

Department of Neurosciences, University of California, San Diego, La Jolla, California 92093-0948, USA. jmhamilton@ucsd.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15327716

Citation

Hamilton, Joanne M., et al. "A Comparison of Episodic Memory Deficits in Neuropathologically-confirmed Dementia With Lewy Bodies and Alzheimer's Disease." Journal of the International Neuropsychological Society : JINS, vol. 10, no. 5, 2004, pp. 689-97.
Hamilton JM, Salmon DP, Galasko D, et al. A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease. J Int Neuropsychol Soc. 2004;10(5):689-97.
Hamilton, J. M., Salmon, D. P., Galasko, D., Delis, D. C., Hansen, L. A., Masliah, E., Thomas, R. G., & Thal, L. J. (2004). A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease. Journal of the International Neuropsychological Society : JINS, 10(5), 689-97.
Hamilton JM, et al. A Comparison of Episodic Memory Deficits in Neuropathologically-confirmed Dementia With Lewy Bodies and Alzheimer's Disease. J Int Neuropsychol Soc. 2004;10(5):689-97. PubMed PMID: 15327716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease. AU - Hamilton,Joanne M, AU - Salmon,David P, AU - Galasko,Douglas, AU - Delis,Dean C, AU - Hansen,Lawrence A, AU - Masliah,Eliezer, AU - Thomas,Ronald G, AU - Thal,Leon J, PY - 2003/06/18/received PY - 2003/11/14/revised PY - 2004/8/26/pubmed PY - 2004/10/27/medline PY - 2004/8/26/entrez SP - 689 EP - 97 JF - Journal of the International Neuropsychological Society : JINS JO - J Int Neuropsychol Soc VL - 10 IS - 5 N2 - Little is known about possible differences in the memory deficits that occur in Dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). We compared 24 autopsy-confirmed DLB and 24 age-, education-, and MMSE-matched autopsy-confirmed AD patients on the California Verbal Learning Test (CVLT) and the Wechsler Memory Scale-Revised Logical Memory subtest. The DLB and AD groups were similarly impaired on CVLT Total Learning (Trials 15) and Long Delayed Free Recall, but the DLB group demonstrated relative improvement in Savings scores and on recognition testing compared to the AD group. Likewise, the patient groups were equally impaired on Logical Memory immediate and delayed recall, but the DLB group's Saving scores were significantly better than those of the AD patients. These results indicate that while both DLB and AD patients exhibit significant memory impairment, the ability to consolidate information may be less severely impaired in DLB patients than in AD patients. SN - 1355-6177 UR - https://www.unboundmedicine.com/medline/citation/15327716/A_comparison_of_episodic_memory_deficits_in_neuropathologically_confirmed_Dementia_with_Lewy_bodies_and_Alzheimer's_disease_ L2 - https://www.cambridge.org/core/product/identifier/S1355617704105043/type/journal_article DB - PRIME DP - Unbound Medicine ER -