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Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis.
Eur Ann Allergy Clin Immunol. 2004 Jun; 36(6):237-40.EA

Abstract

Cetirizine has been demonstrated able of reducing nasal inflammatory infiltration in children with allergic rhinitis and cytokine production in in vitro studies. The aim of this double-blind, placebo-controlled, and randomized study was to evaluate cytokine pattern and inflammatory cells in children with perennial allergic rhinitis, before and after treatment with cetirizine or placebo. Twenty children with perennial allergic rhinitis were evaluated, 13 males and 7 females (mean age 13.4 years). Inflammatory cells and cytokines were evaluated by scraping and nasal lavage, before and after 2-weeks administration of cetirizine or placebo. IL4 and IL8 were measured by immunoassay and inflammatory cells were counted by conventional staining. Cetirizine treatment induced a significant decrease of IL4 (p<0.01) and IL8 levels (p=0.01). A significant reduction of the inflammatory cells was detected in actively-treated children, both concerning neutrophils and eosinophils (p<0.01). Moreover, cetirizine significantly reduced nasal obstruction score (p=0.007). This study shows the cetirizine effectiveness in exerting anti-inflammatory activity by modulating cytokine pattern and by reducing inflammatory infiltration in children with perennial allergic rhinitis.

Authors+Show Affiliations

Ciprandi G
Allergy and ENT Division, Head Neck Dpt., San Martino Hospital, Genoa.
Tosca MA
No affiliation info available
Milanese M
No affiliation info available
Ricca V
No affiliation info available

MeSH

AdolescentAnimalsCetirizineChildDouble-Blind MethodEnzyme-Linked Immunosorbent AssayEosinophilsFemaleHistamine H1 Antagonists, Non-SedatingHumansInterleukin-4Interleukin-8MaleNasal Lavage FluidNasal MucosaNasal ObstructionNeutrophilsPollenProspective StudiesPyroglyphidaeRhinitis, Allergic, PerennialRhinitis, Allergic, SeasonalTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15329007

Citation

Ciprandi, G, et al. "Cetirizine Reduces Cytokines and Inflammatory Cells in Children With Perennial Allergic Rhinitis." European Annals of Allergy and Clinical Immunology, vol. 36, no. 6, 2004, pp. 237-40.
Ciprandi G, Tosca MA, Milanese M, et al. Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis. Eur Ann Allergy Clin Immunol. 2004;36(6):237-40.
Ciprandi, G., Tosca, M. A., Milanese, M., & Ricca, V. (2004). Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis. European Annals of Allergy and Clinical Immunology, 36(6), 237-40.
Ciprandi G, et al. Cetirizine Reduces Cytokines and Inflammatory Cells in Children With Perennial Allergic Rhinitis. Eur Ann Allergy Clin Immunol. 2004;36(6):237-40. PubMed PMID: 15329007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis. AU - Ciprandi,G, AU - Tosca,M A, AU - Milanese,M, AU - Ricca,V, PY - 2004/8/27/pubmed PY - 2004/10/6/medline PY - 2004/8/27/entrez SP - 237 EP - 40 JF - European annals of allergy and clinical immunology JO - Eur Ann Allergy Clin Immunol VL - 36 IS - 6 N2 - Cetirizine has been demonstrated able of reducing nasal inflammatory infiltration in children with allergic rhinitis and cytokine production in in vitro studies. The aim of this double-blind, placebo-controlled, and randomized study was to evaluate cytokine pattern and inflammatory cells in children with perennial allergic rhinitis, before and after treatment with cetirizine or placebo. Twenty children with perennial allergic rhinitis were evaluated, 13 males and 7 females (mean age 13.4 years). Inflammatory cells and cytokines were evaluated by scraping and nasal lavage, before and after 2-weeks administration of cetirizine or placebo. IL4 and IL8 were measured by immunoassay and inflammatory cells were counted by conventional staining. Cetirizine treatment induced a significant decrease of IL4 (p<0.01) and IL8 levels (p=0.01). A significant reduction of the inflammatory cells was detected in actively-treated children, both concerning neutrophils and eosinophils (p<0.01). Moreover, cetirizine significantly reduced nasal obstruction score (p=0.007). This study shows the cetirizine effectiveness in exerting anti-inflammatory activity by modulating cytokine pattern and by reducing inflammatory infiltration in children with perennial allergic rhinitis. SN - 1764-1489 UR - https://www.unboundmedicine.com/medline/citation/15329007/Cetirizine_reduces_cytokines_and_inflammatory_cells_in_children_with_perennial_allergic_rhinitis_ L2 - https://www.diseaseinfosearch.org/result/7665 DB - PRIME DP - Unbound Medicine ER -