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Antidiuretic hormone in elderly male patients with severe nocturia: a circadian study.
BJU Int. 2004 Sep; 94(4):571-5.BI

Abstract

OBJECTIVE

To investigate the circadian variation of plasma antidiuretic hormone (ADH) and urine output in patients with severe nocturia (> three times per night) and to assess the effect of oral desmopressin on nocturnal urine output in these patients.

PATIENTS AND METHODS

Twelve patients with severe nocturia and five age-matched controls without were assessed over 24 h (circadian sampling) during a 72-h hospital admission. Blood levels of ADH and changes of urine output were measured in the patients before and after the oral administration of desmopressin (0.2 mg, at 22.00 hours in the second day), and in the controls not treated with desmopressin.

RESULTS

Compared with the normal control, the patients had no diurnal variation in urine output and greater nocturnal urine production, associated with a lack of nocturnal increase in ADH level. Compared with the baseline urine output, desmopressin significantly decreased night-time (23.00-08.00 hour) urine output in the patients (P < 0.05). Desmopressin significantly increased the osmolality of night-time urine (P < 0.05), and there was no systemic adverse reaction.

CONCLUSIONS

Severe nocturia in a large proportion of elderly men with lower urinary tract symptoms is caused by nocturnal polyuria and natriuresis, because they have no nocturnal increase in ADH. These results suggest that desmopressin may be effective in decreasing nocturnal urine production in patients with severe nocturia who do not respond to conventional treatment.

Authors+Show Affiliations

Department of Urology, Korea University College of Medicine, Seoul, Korea. dgmoon@korea.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15329115

Citation

Moon, Du Geon, et al. "Antidiuretic Hormone in Elderly Male Patients With Severe Nocturia: a Circadian Study." BJU International, vol. 94, no. 4, 2004, pp. 571-5.
Moon DG, Jin MH, Lee JG, et al. Antidiuretic hormone in elderly male patients with severe nocturia: a circadian study. BJU Int. 2004;94(4):571-5.
Moon, D. G., Jin, M. H., Lee, J. G., Kim, J. J., Kim, M. G., & Cha, D. R. (2004). Antidiuretic hormone in elderly male patients with severe nocturia: a circadian study. BJU International, 94(4), 571-5.
Moon DG, et al. Antidiuretic Hormone in Elderly Male Patients With Severe Nocturia: a Circadian Study. BJU Int. 2004;94(4):571-5. PubMed PMID: 15329115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiuretic hormone in elderly male patients with severe nocturia: a circadian study. AU - Moon,Du Geon, AU - Jin,Myeong Heon, AU - Lee,Jeong Gu, AU - Kim,Je Jong, AU - Kim,Myung Gon, AU - Cha,Dae Ryong, PY - 2004/8/27/pubmed PY - 2004/10/19/medline PY - 2004/8/27/entrez SP - 571 EP - 5 JF - BJU international JO - BJU Int VL - 94 IS - 4 N2 - OBJECTIVE: To investigate the circadian variation of plasma antidiuretic hormone (ADH) and urine output in patients with severe nocturia (> three times per night) and to assess the effect of oral desmopressin on nocturnal urine output in these patients. PATIENTS AND METHODS: Twelve patients with severe nocturia and five age-matched controls without were assessed over 24 h (circadian sampling) during a 72-h hospital admission. Blood levels of ADH and changes of urine output were measured in the patients before and after the oral administration of desmopressin (0.2 mg, at 22.00 hours in the second day), and in the controls not treated with desmopressin. RESULTS: Compared with the normal control, the patients had no diurnal variation in urine output and greater nocturnal urine production, associated with a lack of nocturnal increase in ADH level. Compared with the baseline urine output, desmopressin significantly decreased night-time (23.00-08.00 hour) urine output in the patients (P < 0.05). Desmopressin significantly increased the osmolality of night-time urine (P < 0.05), and there was no systemic adverse reaction. CONCLUSIONS: Severe nocturia in a large proportion of elderly men with lower urinary tract symptoms is caused by nocturnal polyuria and natriuresis, because they have no nocturnal increase in ADH. These results suggest that desmopressin may be effective in decreasing nocturnal urine production in patients with severe nocturia who do not respond to conventional treatment. SN - 1464-4096 UR - https://www.unboundmedicine.com/medline/citation/15329115/Antidiuretic_hormone_in_elderly_male_patients_with_severe_nocturia:_a_circadian_study_ L2 - https://doi.org/10.1111/j.1464-410X.2004.05003.x DB - PRIME DP - Unbound Medicine ER -