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Pharmacotherapy of obsessive compulsive disorder.
J Clin Psychiatry. 1992 Apr; 53 Suppl:29-37.JC

Abstract

The authors briefly review studies of the efficacy of potent serotonin reuptake inhibitors (SRIs) (e.g., clomipramine, fluvoxamine) in obsessive compulsive disorder (OCD) and compare the use of antidepressants in the treatment of depression and OCD. They propose an algorithm for those patients with OCD who fail to respond to an adequate trial with a potent SRI and discuss the promise and limitations of adding tryptophan, fenfluramine, lithium, buspirone, or a neuroleptic to ongoing SRI therapy. Other biological approaches (e.g., ECT, psychosurgery) are considered in terms of their narrowly defined roles in the treatment of patients with SRI-resistant OCD.

Authors+Show Affiliations

Clinical Neuroscience Research Unit, Yale University School of Medicine, New Haven, CT 06519.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

1532962

Citation

Goodman, W K., et al. "Pharmacotherapy of Obsessive Compulsive Disorder." The Journal of Clinical Psychiatry, vol. 53 Suppl, 1992, pp. 29-37.
Goodman WK, McDougle CJ, Price LH. Pharmacotherapy of obsessive compulsive disorder. J Clin Psychiatry. 1992;53 Suppl:29-37.
Goodman, W. K., McDougle, C. J., & Price, L. H. (1992). Pharmacotherapy of obsessive compulsive disorder. The Journal of Clinical Psychiatry, 53 Suppl, 29-37.
Goodman WK, McDougle CJ, Price LH. Pharmacotherapy of Obsessive Compulsive Disorder. J Clin Psychiatry. 1992;53 Suppl:29-37. PubMed PMID: 1532962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacotherapy of obsessive compulsive disorder. AU - Goodman,W K, AU - McDougle,C J, AU - Price,L H, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 29 EP - 37 JF - The Journal of clinical psychiatry JO - J Clin Psychiatry VL - 53 Suppl N2 - The authors briefly review studies of the efficacy of potent serotonin reuptake inhibitors (SRIs) (e.g., clomipramine, fluvoxamine) in obsessive compulsive disorder (OCD) and compare the use of antidepressants in the treatment of depression and OCD. They propose an algorithm for those patients with OCD who fail to respond to an adequate trial with a potent SRI and discuss the promise and limitations of adding tryptophan, fenfluramine, lithium, buspirone, or a neuroleptic to ongoing SRI therapy. Other biological approaches (e.g., ECT, psychosurgery) are considered in terms of their narrowly defined roles in the treatment of patients with SRI-resistant OCD. SN - 0160-6689 UR - https://www.unboundmedicine.com/medline/citation/1532962/Pharmacotherapy_of_obsessive_compulsive_disorder_ L2 - http://www.diseaseinfosearch.org/result/5285 DB - PRIME DP - Unbound Medicine ER -