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Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults.

Abstract

OBJECTIVE

Within a prospective study, we explored the associations between dietary intake of fatty acids, antioxidants and relevant food sources of these nutrients on the clinical manifestation of asthma in adulthood.

METHOD

A total of 105 newly physician-diagnosed cases of asthma from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort were identified during follow-up and matched with 420 controls. Baseline dietary intake was obtained by means of validated food frequency questionnaires. The association of dietary intake variables and asthma risk was explored by unconditional logistic regression models.

RESULTS

A high intake of oleic acid (C18:1 n-9) was positively associated with asthma (P-value for trend 0.035), while no significant associations were found for the other dietary fatty acids. Most prominently, a high margarine intake increased the risk of onset of asthma in adulthood (adjusted odds ratio (OR) 3rd tertile: 1.73 (95% confidence interval (95% CI): 1.05-2.87), P for trend=0.050), the effect being stronger in men (2nd tertile: OR=1.66, 3rd tertile: OR=2.51) than in women (2nd tertile: OR=0.91; 3rd tertile: OR=1.47). The dietary intake of antioxidants and their main food sources had no effect on asthma risk.

CONCLUSIONS

In summary, the present results provide evidence that even in adulthood a high margarine intake increases the risk of clinical onset of asthma. Whether oleic acid may serve as a proxy for margarine-derived trans-fatty acids (C18:1 t9) remains to be clarified.

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  • Authors+Show Affiliations

    ,

    Division of Clinical Epidemiology, DKFZ German Cancer Research Center, Heidelberg, Germany. g.nagel@dkfz-heidelberg.de

    Source

    MeSH

    Adult
    Age of Onset
    Aged
    Antioxidants
    Asthma
    Case-Control Studies
    Cohort Studies
    Confidence Intervals
    Fatty Acids
    Female
    Follow-Up Studies
    Humans
    Logistic Models
    Male
    Margarine
    Middle Aged
    Odds Ratio
    Oleic Acid
    Prospective Studies
    Risk Factors
    Sex Factors
    Surveys and Questionnaires
    Trans Fatty Acids

    Pub Type(s)

    Journal Article
    Multicenter Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15329676

    Citation

    Nagel, G, and J Linseisen. "Dietary Intake of Fatty Acids, Antioxidants and Selected Food Groups and Asthma in Adults." European Journal of Clinical Nutrition, vol. 59, no. 1, 2005, pp. 8-15.
    Nagel G, Linseisen J. Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. Eur J Clin Nutr. 2005;59(1):8-15.
    Nagel, G., & Linseisen, J. (2005). Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. European Journal of Clinical Nutrition, 59(1), pp. 8-15.
    Nagel G, Linseisen J. Dietary Intake of Fatty Acids, Antioxidants and Selected Food Groups and Asthma in Adults. Eur J Clin Nutr. 2005;59(1):8-15. PubMed PMID: 15329676.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of fatty acids, antioxidants and selected food groups and asthma in adults. AU - Nagel,G, AU - Linseisen,J, PY - 2004/8/27/pubmed PY - 2005/4/9/medline PY - 2004/8/27/entrez SP - 8 EP - 15 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 1 N2 - OBJECTIVE: Within a prospective study, we explored the associations between dietary intake of fatty acids, antioxidants and relevant food sources of these nutrients on the clinical manifestation of asthma in adulthood. METHOD: A total of 105 newly physician-diagnosed cases of asthma from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heidelberg cohort were identified during follow-up and matched with 420 controls. Baseline dietary intake was obtained by means of validated food frequency questionnaires. The association of dietary intake variables and asthma risk was explored by unconditional logistic regression models. RESULTS: A high intake of oleic acid (C18:1 n-9) was positively associated with asthma (P-value for trend 0.035), while no significant associations were found for the other dietary fatty acids. Most prominently, a high margarine intake increased the risk of onset of asthma in adulthood (adjusted odds ratio (OR) 3rd tertile: 1.73 (95% confidence interval (95% CI): 1.05-2.87), P for trend=0.050), the effect being stronger in men (2nd tertile: OR=1.66, 3rd tertile: OR=2.51) than in women (2nd tertile: OR=0.91; 3rd tertile: OR=1.47). The dietary intake of antioxidants and their main food sources had no effect on asthma risk. CONCLUSIONS: In summary, the present results provide evidence that even in adulthood a high margarine intake increases the risk of clinical onset of asthma. Whether oleic acid may serve as a proxy for margarine-derived trans-fatty acids (C18:1 t9) remains to be clarified. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15329676/Dietary_intake_of_fatty_acids_antioxidants_and_selected_food_groups_and_asthma_in_adults_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602025 DB - PRIME DP - Unbound Medicine ER -