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Quantification of hydrogen cyanide in humid air by selected ion flow tube mass spectrometry.
Rapid Commun Mass Spectrom. 2004; 18(16):1869-73.RC

Abstract

Following our recent observation that Pseudomonas bacteria in vitro emit hydrogen cyanide, we have found it necessary to investigate the ion chemistry of this compound and to extend the kinetics database for selected ion flow tube mass spectrometry (SIFT-MS) to allow the accurate quantification of HCN in moist air samples, including exhaled breath. Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed. Thus, the reactions of H3O+(H2O)0,1,2,3 ions with HCN molecules have been studied in the presence of varying concentrations of water vapour, reactions on which SIFT-MS analysis of HCN relies. The results of these experiments have allowed an analytical procedure to be developed which has extended the kinetics database of SIFT-MS, such that HCN can now be quantified in humid air and in exhaled breath.

Authors+Show Affiliations

V. Cermák Laboratory, J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejskova 3, 182 23 Prague 8.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15329882

Citation

Spanĕl, Patrik, et al. "Quantification of Hydrogen Cyanide in Humid Air By Selected Ion Flow Tube Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 18, no. 16, 2004, pp. 1869-73.
Spanĕl P, Wang T, Smith D. Quantification of hydrogen cyanide in humid air by selected ion flow tube mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(16):1869-73.
Spanĕl, P., Wang, T., & Smith, D. (2004). Quantification of hydrogen cyanide in humid air by selected ion flow tube mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 18(16), 1869-73.
Spanĕl P, Wang T, Smith D. Quantification of Hydrogen Cyanide in Humid Air By Selected Ion Flow Tube Mass Spectrometry. Rapid Commun Mass Spectrom. 2004;18(16):1869-73. PubMed PMID: 15329882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of hydrogen cyanide in humid air by selected ion flow tube mass spectrometry. AU - Spanĕl,Patrik, AU - Wang,Tianshu, AU - Smith,David, PY - 2004/8/27/pubmed PY - 2004/10/7/medline PY - 2004/8/27/entrez SP - 1869 EP - 73 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 18 IS - 16 N2 - Following our recent observation that Pseudomonas bacteria in vitro emit hydrogen cyanide, we have found it necessary to investigate the ion chemistry of this compound and to extend the kinetics database for selected ion flow tube mass spectrometry (SIFT-MS) to allow the accurate quantification of HCN in moist air samples, including exhaled breath. Because of the proximity of the proton affinities of HCN and H2O molecules, the presence of water vapour can significantly distort HCN analysis in the presence of water vapour and a more sophisticated analytical procedure has to be developed. Thus, the reactions of H3O+(H2O)0,1,2,3 ions with HCN molecules have been studied in the presence of varying concentrations of water vapour, reactions on which SIFT-MS analysis of HCN relies. The results of these experiments have allowed an analytical procedure to be developed which has extended the kinetics database of SIFT-MS, such that HCN can now be quantified in humid air and in exhaled breath. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/15329882/Quantification_of_hydrogen_cyanide_in_humid_air_by_selected_ion_flow_tube_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.1566 DB - PRIME DP - Unbound Medicine ER -