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Urinary N-acetyl-beta-D-glucosaminidase in children with diabetes as an early marker of diabetic nephropathy.
East Mediterr Health J 2002; 8(1):24-30EM

Abstract

We investigated urinary N-acetyl-beta-D-glucosaminidase (NAG) levels in children with type 1 diabetes as an early marker of tubular damage and studied its correlation with microalbuminuria and glycaemic control. The study group comprised 42 children with type 1 diabetes and 20 healthy children as control. Urinary NAG to urinary creatinine ratio, microalbuminuria, glycated haemoglobin (Hb A1c), blood urea and serum creatinine were estimated. Urinary NAG levels in the children with diabetes were significantly higher than those of controls. There were positive correlations between urinary NAG levels and microalbuminuria, Hb A1c and systolic and diastolic blood pressure values. We found that 59.5% of diabetic children were positive for urinary NAG, while 38.1% of them were positive for microalbuminuria.

Authors+Show Affiliations

National Institute of Diabetes and Endocrinology, Cairo, Egypt.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

15330557

Citation

Abdel Shakour, S, et al. "Urinary N-acetyl-beta-D-glucosaminidase in Children With Diabetes as an Early Marker of Diabetic Nephropathy." Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, vol. 8, no. 1, 2002, pp. 24-30.
Abdel Shakour S, el-Hefnawy H, el-Yamani MY, et al. Urinary N-acetyl-beta-D-glucosaminidase in children with diabetes as an early marker of diabetic nephropathy. East Mediterr Health J. 2002;8(1):24-30.
Abdel Shakour, S., el-Hefnawy, H., el-Yamani, M. Y., & Azmi, Y. (2002). Urinary N-acetyl-beta-D-glucosaminidase in children with diabetes as an early marker of diabetic nephropathy. Eastern Mediterranean Health Journal = La Revue De Sante De La Mediterranee Orientale = al-Majallah Al-sihhiyah Li-sharq Al-mutawassit, 8(1), pp. 24-30.
Abdel Shakour S, et al. Urinary N-acetyl-beta-D-glucosaminidase in Children With Diabetes as an Early Marker of Diabetic Nephropathy. East Mediterr Health J. 2002;8(1):24-30. PubMed PMID: 15330557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary N-acetyl-beta-D-glucosaminidase in children with diabetes as an early marker of diabetic nephropathy. AU - Abdel Shakour,S, AU - el-Hefnawy,H, AU - el-Yamani,M Y, AU - Azmi,Y, PY - 2004/8/28/pubmed PY - 2004/10/16/medline PY - 2004/8/28/entrez SP - 24 EP - 30 JF - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JO - East. Mediterr. Health J. VL - 8 IS - 1 N2 - We investigated urinary N-acetyl-beta-D-glucosaminidase (NAG) levels in children with type 1 diabetes as an early marker of tubular damage and studied its correlation with microalbuminuria and glycaemic control. The study group comprised 42 children with type 1 diabetes and 20 healthy children as control. Urinary NAG to urinary creatinine ratio, microalbuminuria, glycated haemoglobin (Hb A1c), blood urea and serum creatinine were estimated. Urinary NAG levels in the children with diabetes were significantly higher than those of controls. There were positive correlations between urinary NAG levels and microalbuminuria, Hb A1c and systolic and diastolic blood pressure values. We found that 59.5% of diabetic children were positive for urinary NAG, while 38.1% of them were positive for microalbuminuria. SN - 1020-3397 UR - https://www.unboundmedicine.com/medline/citation/15330557/Urinary_N_acetyl_beta_D_glucosaminidase_in_children_with_diabetes_as_an_early_marker_of_diabetic_nephropathy_ L2 - http://applications.emro.who.int/emhj/0801/EMHJ_2002_8_1_24_30.pdf DB - PRIME DP - Unbound Medicine ER -