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Risk factors for erosive esophagitis: a multivariate analysis based on the ProGERD study initiative.
Am J Gastroenterol 2004; 99(9):1652-6AJ

Abstract

OBJECTIVES

Gastroesophageal reflux disease can be divided into three categories: nonerosive GERD (NERD), erosive GERD (ERD), and Barrett's esophagus. A shift among these categories rarely occurs. The aim of the present study was to elucidate potential patient-associated risk factors associated with ERD.

METHODS

A total of 6,215 patients with troublesome heartburn were recruited to a large, prospective, multicenter open cohort study comprising an initial treatment phase and a 5-yr follow-up phase. Each center planned to recruit an equal number of patients with NERD and ERD. All patients underwent an interview based on standardized questionnaires, a physical examination, and endoscopy with biopsies. Data were analyzed by multiple logistic regression analysis.

RESULTS

Risk factor analysis was performed on 5,289 patients (NERD: n = 2,834; ERD: n = 2,455), which was the intent-to-treat population excluding patients with suspected/proven complicated reflux disease. Stepwise regression analysis identified the following independent predictors of ERD: male gender, overweight, regular use of alcohol, a history of GERD >1 yr, and smoker or ex-smoker. A higher level of education and a positive Helicobacter pylori (H. pylori) status were associated with a lower risk of ERD.

CONCLUSIONS

Some patient-associated factors increase the risk of erosive esophagitis as opposed to nonerosive reflux disease. However, no single factor or combination of factors is capable of predicting mucosal damage with clinically sufficient certainty. Thus, endoscopy is still required in all GERD patients if valid information on the state of the esophageal mucosa is needed.

Authors+Show Affiliations

Department of Medicine, Jung-Stilling Hospital, Wichernstrasse 40, 57074 Siegen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15330897

Citation

Labenz, Joachim, et al. "Risk Factors for Erosive Esophagitis: a Multivariate Analysis Based On the ProGERD Study Initiative." The American Journal of Gastroenterology, vol. 99, no. 9, 2004, pp. 1652-6.
Labenz J, Jaspersen D, Kulig M, et al. Risk factors for erosive esophagitis: a multivariate analysis based on the ProGERD study initiative. Am J Gastroenterol. 2004;99(9):1652-6.
Labenz, J., Jaspersen, D., Kulig, M., Leodolter, A., Lind, T., Meyer-Sabellek, W., ... Malfertheiner, P. (2004). Risk factors for erosive esophagitis: a multivariate analysis based on the ProGERD study initiative. The American Journal of Gastroenterology, 99(9), pp. 1652-6.
Labenz J, et al. Risk Factors for Erosive Esophagitis: a Multivariate Analysis Based On the ProGERD Study Initiative. Am J Gastroenterol. 2004;99(9):1652-6. PubMed PMID: 15330897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for erosive esophagitis: a multivariate analysis based on the ProGERD study initiative. AU - Labenz,Joachim, AU - Jaspersen,Daniel, AU - Kulig,Michael, AU - Leodolter,Andreas, AU - Lind,Tore, AU - Meyer-Sabellek,Wolfgang, AU - Stolte,Manfred, AU - Vieth,Micheal, AU - Willich,Stefan, AU - Malfertheiner,Peter, PY - 2004/8/28/pubmed PY - 2004/10/8/medline PY - 2004/8/28/entrez SP - 1652 EP - 6 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 99 IS - 9 N2 - OBJECTIVES: Gastroesophageal reflux disease can be divided into three categories: nonerosive GERD (NERD), erosive GERD (ERD), and Barrett's esophagus. A shift among these categories rarely occurs. The aim of the present study was to elucidate potential patient-associated risk factors associated with ERD. METHODS: A total of 6,215 patients with troublesome heartburn were recruited to a large, prospective, multicenter open cohort study comprising an initial treatment phase and a 5-yr follow-up phase. Each center planned to recruit an equal number of patients with NERD and ERD. All patients underwent an interview based on standardized questionnaires, a physical examination, and endoscopy with biopsies. Data were analyzed by multiple logistic regression analysis. RESULTS: Risk factor analysis was performed on 5,289 patients (NERD: n = 2,834; ERD: n = 2,455), which was the intent-to-treat population excluding patients with suspected/proven complicated reflux disease. Stepwise regression analysis identified the following independent predictors of ERD: male gender, overweight, regular use of alcohol, a history of GERD >1 yr, and smoker or ex-smoker. A higher level of education and a positive Helicobacter pylori (H. pylori) status were associated with a lower risk of ERD. CONCLUSIONS: Some patient-associated factors increase the risk of erosive esophagitis as opposed to nonerosive reflux disease. However, no single factor or combination of factors is capable of predicting mucosal damage with clinically sufficient certainty. Thus, endoscopy is still required in all GERD patients if valid information on the state of the esophageal mucosa is needed. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15330897/Risk_factors_for_erosive_esophagitis:_a_multivariate_analysis_based_on_the_ProGERD_study_initiative_ L2 - http://Insights.ovid.com/pubmed?pmid=15330897 DB - PRIME DP - Unbound Medicine ER -