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Nonalcoholic fatty liver disease in the pediatric population.
Clin Liver Dis 2004; 8(3):549-58, viii-ixCL

Abstract

Nonalcoholic fatty liver disease (NAFLD) covers the spectrum of features found in liver laden with macrovesicular fat and variable degrees of inflammation, cell injury, and fibrosis. By definition, NAFLD excludes those with significant ingestion of alcohol or alternative potential cause of steatohepatitis. NAFLD develops with rare exception in children who are obese. Given the rapid rise in prevalence of obesity in children globally, NAFLD is now recognized as the most common cause of liver disease in pediatrics. In obese individuals, Hispanic ethnicity and male gender appear to increase risk. Recent studies suggest that insulin resistance and oxidative stress are important in pathogenesis. Treatment trials are underway to determine if reduction of insulin resistance or oxidative stress will favorably affect outcome. This review summarizes what is known about pediatric nonalcoholic steatohepatitis in terms of prevalence, demographics, clinical presentation, histology,pathogenesis, and treatment. Important differences between pediatric and adult fatty liver disease are highlighted.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego Medical Center and Children's Hospital, 200 W. Arbor Drive, San Diego, CA 92103-8450, USA. jolavine@ucsd.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15331063

Citation

Lavine, Joel E., and Jeffrey B. Schwimmer. "Nonalcoholic Fatty Liver Disease in the Pediatric Population." Clinics in Liver Disease, vol. 8, no. 3, 2004, pp. 549-58, viii-ix.
Lavine JE, Schwimmer JB. Nonalcoholic fatty liver disease in the pediatric population. Clin Liver Dis. 2004;8(3):549-58, viii-ix.
Lavine, J. E., & Schwimmer, J. B. (2004). Nonalcoholic fatty liver disease in the pediatric population. Clinics in Liver Disease, 8(3), pp. 549-58, viii-ix.
Lavine JE, Schwimmer JB. Nonalcoholic Fatty Liver Disease in the Pediatric Population. Clin Liver Dis. 2004;8(3):549-58, viii-ix. PubMed PMID: 15331063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonalcoholic fatty liver disease in the pediatric population. AU - Lavine,Joel E, AU - Schwimmer,Jeffrey B, PY - 2004/8/28/pubmed PY - 2004/11/4/medline PY - 2004/8/28/entrez SP - 549-58, viii-ix JF - Clinics in liver disease JO - Clin Liver Dis VL - 8 IS - 3 N2 - Nonalcoholic fatty liver disease (NAFLD) covers the spectrum of features found in liver laden with macrovesicular fat and variable degrees of inflammation, cell injury, and fibrosis. By definition, NAFLD excludes those with significant ingestion of alcohol or alternative potential cause of steatohepatitis. NAFLD develops with rare exception in children who are obese. Given the rapid rise in prevalence of obesity in children globally, NAFLD is now recognized as the most common cause of liver disease in pediatrics. In obese individuals, Hispanic ethnicity and male gender appear to increase risk. Recent studies suggest that insulin resistance and oxidative stress are important in pathogenesis. Treatment trials are underway to determine if reduction of insulin resistance or oxidative stress will favorably affect outcome. This review summarizes what is known about pediatric nonalcoholic steatohepatitis in terms of prevalence, demographics, clinical presentation, histology,pathogenesis, and treatment. Important differences between pediatric and adult fatty liver disease are highlighted. SN - 1089-3261 UR - https://www.unboundmedicine.com/medline/citation/15331063/Nonalcoholic_fatty_liver_disease_in_the_pediatric_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089326104000406 DB - PRIME DP - Unbound Medicine ER -