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Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease.
Clin Liver Dis. 2004 Aug; 8(3):575-94, ix.CL

Abstract

The prevalence of obesity has reached epidemic proportions in most of the western world. Current estimates suggest that 22.5%of the population of the United States suffers from obesity and is at risk for development of obesity-related complications, including hypertension, coronary artery disease, diabetes, hyperlipidemia,increased predisposition for various cancers, and nonalcoholic fatty liver disease. Fatty liver disease is currently the most common abnormality observed in hepatology practice. Since it was first reported in the 1980s in obese diabetic females, our understanding of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) has undergone significant metamorphosis. It is now universally accepted that insulin resistance and subsequent hyperinsulinemia are key factors that lead to both NAFL and NASH.This article reviews the role of insulin resistance in the genesis of these conditions.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University, Box 980711 Richmond, VA 23298-0711, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15331065

Citation

Choudhury, Jayanta, and Arun J. Sanyal. "Insulin Resistance and the Pathogenesis of Nonalcoholic Fatty Liver Disease." Clinics in Liver Disease, vol. 8, no. 3, 2004, pp. 575-94, ix.
Choudhury J, Sanyal AJ. Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease. Clin Liver Dis. 2004;8(3):575-94, ix.
Choudhury, J., & Sanyal, A. J. (2004). Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease. Clinics in Liver Disease, 8(3), 575-94, ix.
Choudhury J, Sanyal AJ. Insulin Resistance and the Pathogenesis of Nonalcoholic Fatty Liver Disease. Clin Liver Dis. 2004;8(3):575-94, ix. PubMed PMID: 15331065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Insulin resistance and the pathogenesis of nonalcoholic fatty liver disease. AU - Choudhury,Jayanta, AU - Sanyal,Arun J, PY - 2004/8/28/pubmed PY - 2004/11/4/medline PY - 2004/8/28/entrez SP - 575-94, ix JF - Clinics in liver disease JO - Clin Liver Dis VL - 8 IS - 3 N2 - The prevalence of obesity has reached epidemic proportions in most of the western world. Current estimates suggest that 22.5%of the population of the United States suffers from obesity and is at risk for development of obesity-related complications, including hypertension, coronary artery disease, diabetes, hyperlipidemia,increased predisposition for various cancers, and nonalcoholic fatty liver disease. Fatty liver disease is currently the most common abnormality observed in hepatology practice. Since it was first reported in the 1980s in obese diabetic females, our understanding of nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) has undergone significant metamorphosis. It is now universally accepted that insulin resistance and subsequent hyperinsulinemia are key factors that lead to both NAFL and NASH.This article reviews the role of insulin resistance in the genesis of these conditions. SN - 1089-3261 UR - https://www.unboundmedicine.com/medline/citation/15331065/Insulin_resistance_and_the_pathogenesis_of_nonalcoholic_fatty_liver_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1089326104000364 DB - PRIME DP - Unbound Medicine ER -